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Chemical Structure| 1009036-29-6 Chemical Structure| 1009036-29-6

Structure of 1009036-29-6

Chemical Structure| 1009036-29-6

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Product Details of [ 1009036-29-6 ]

CAS No. :1009036-29-6
Formula : C8H6FN3
M.W : 163.15
SMILES Code : NC1=C2C=CC(F)=CC2=NC=N1
MDL No. :MFCD09027695

Safety of [ 1009036-29-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 1009036-29-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1009036-29-6 ]

[ 1009036-29-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1009036-29-6 ]
  • [ 56008-20-9 ]
  • 1-(4-Amino-quinazolin-7-yl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-indol-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
26% With sodium hydride; In ISOPROPYLAMIDE; at 160℃; for 0.333333h;Microwave irradiation; A solution of 7-Fluoro-quinazolin-4-ylamine (0.2203 g, 1.35 mmol), 6,6,6,-trimethyl-1,5,6,7-tetrahydro-indol-4-one (0.286 g, 1.62 mmol) and NaH (60% suspension in mineral oil, 0.081 g, 2.025 mmol) in dimethylacetamide (5 mL) is microwaved at 160 C. for 20 min. The reaction mixture is poured onto a saturated solution of NH4Cl (5 mL), and the aqueous phase is extracted with EtOAc (3×). The combined organic layers are washed with brine, dried over MgSO4, and evaporated to dryness. Purification of the crude material by column chromatography (5% MeOH in CH2Cl2) affords 1-(4-Amino-quinazolin-7-yl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-indol-4-one (0.1131 g, 26%). LC/MS m/z=321 [M+H]+.
 

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