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Chemical Structure| 1006334-29-7 Chemical Structure| 1006334-29-7

Structure of 1006334-29-7

Chemical Structure| 1006334-29-7

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Product Details of [ 1006334-29-7 ]

CAS No. :1006334-29-7
Formula : C13H12F3N3
M.W : 267.25
SMILES Code : NC1=CC=C(N2N=C(C(F)(F)F)C=C2C3CC3)C=C1
MDL No. :MFCD08558449

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Application In Synthesis of [ 1006334-29-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1006334-29-7 ]

[ 1006334-29-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 20485-41-0 ]
  • [ 1006334-29-7 ]
  • [ 541-41-3 ]
  • [ 1288341-63-8 ]
YieldReaction ConditionsOperation in experiment
Example 76l-{4-[5-cycIopropyl-3-(trifluoromethyl)-lH-pyrazol-l-yI]phenyl}-3-(4-methylthiazol-5- yl)urea:[320] <strong>[20485-41-0]4-methylthiazole-5-carboxylic acid</strong> (lg, 6.99 mmol) was dissolved in acetone, water mixture (50 ml and 5 ml) and cooled to -5 °C. Ethyl choroformate was added slowly to this mixture and stirred at same temperature for 30 mins. At this stage sodium azide (0.9 g, 13.8 mmol) was added and stirred for 30 mins at the same temperature. Water was added to the reaction mixture and extracted with Et20 and ether was removed to obtain the crude. Crude was dissolved in dioxane, intermediate 31 was added and refluxed for 30 mins. Work up (AcOEt:H20) followed by purification on 60-120 mesh silica gel using EA and Peteher (45:50) as eluent afforded the title compound (2.1 g) as a pale yellow solid. M. P.: 124-126 °C. -NMR (delta ppm, DMSO-
 

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