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Chemical Structure| 1005342-94-8 Chemical Structure| 1005342-94-8

Structure of 1005342-94-8

Chemical Structure| 1005342-94-8

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Product Details of [ 1005342-94-8 ]

CAS No. :1005342-94-8
Formula : C8H9BrN2O2
M.W : 245.07
SMILES Code : O=C(N(OC)C)C1=NC=CC(Br)=C1
MDL No. :MFCD13191447

Safety of [ 1005342-94-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 1005342-94-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1005342-94-8 ]

[ 1005342-94-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1005342-94-8 ]
  • [ 131747-63-2 ]
YieldReaction ConditionsOperation in experiment
89% With lithium aluminium tetrahydride; In tetrahydrofuran; at -78℃; for 1h; 4-bromo-N-methoxy-N-methylpicolinamide (42; 5.84 g, 23.8 mmol) was dissolved in anhydrous THF (100 ml) and cooled to -78° C and 1.0 M lithium aluminum hydride in THF (14.3 ml, 14.3 mmol) was added via syringe and then the resulting mixture was stirred for 1 hour. 1 M NaOH (20 ml) and water (20 ml) was added carefully to the reaction mixture, and then the resulting solution was stirred for 30 minutes. Ethyl acetate and water was added, the organic phase was washed with water and brine, dried over Na2SO4 and concentrated to give A- bromopicolinaldehyde 43 as a yellow oil (3.95 g, yield: 89percent). MS calcd for C6H4BrNO: 186; found: 187 [M+l].
 

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