Home Cart Sign in  
Chemical Structure| 1005196-13-3 Chemical Structure| 1005196-13-3

Structure of 1005196-13-3

Chemical Structure| 1005196-13-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1005196-13-3 ]

CAS No. :1005196-13-3
Formula : C9H6FNS
M.W : 179.21
SMILES Code : FC1=CC=C(C2=NC=CS2)C=C1
MDL No. :MFCD12033576

Safety of [ 1005196-13-3 ]

Application In Synthesis of [ 1005196-13-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1005196-13-3 ]

[ 1005196-13-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 855636-38-3 ]
  • [ 1005196-13-3 ]
  • [ 1429329-82-7 ]
YieldReaction ConditionsOperation in experiment
75% -(4-Fluorophenyl)thiazol-5-yl)(pyridin-4-yl)methanol To a solution of diisopropylamine (0.55 mL, 3.9 mmol) in dry THF (10 mL) at -78C was added n-BuLi (2.4 mL, 3.9 mmol) dropwise, and then the mixture was stirred for 30 min to produce LDA. A solution of 2-(4-fluorophenyl)thiazole (0.5 g, 2.79 mmol) in dry THF (10 mL) at -78C was added dropwise to the above LDA solution, and the mixture was stirred for 30 min. To this reaction mixture was added <strong>[855636-38-3]isonicotinaldehyde</strong> (0.298 g, 2.79 mmol) dropwise and the mixture was stirred for 1 hour at -78C. The reaction was quenched with ammonium chloride solution (10 mL), extracted with ethyl acetate (2 x 20 mL), washed with brine solution (20 mL), dried over sodium sulfate, concentrated under reduced pressure and purified by silica gel column chromatography (100-200 mesh silica gel; using 10% MeOH in DCM) to obtain 2-(4-fluorophenyl)thiazol-5-yl)(pyridin-4-yl)methanol (0.6 g, 75% yield). 1H NMR (400 MHz, DMSO-d6): delta 8.56 (d, 2H), 7.91(dd, 2H), 7.79 (s, 1H), 7.44 (d, 2H), 7.28 (ds, 2H), 6.71(d, 1H), 6.12 (d, 1H); LC-MS m/z calculated for [M+H]+ 287.06 found 287.02.
  • 2
  • [ 68-12-2 ]
  • [ 1005196-13-3 ]
  • [ 914348-80-4 ]
YieldReaction ConditionsOperation in experiment
100% To a mixture of 31c (1.56 g, 8.76 mmol) in THF (60 mL) was added a 2.5 M solution of n-BuLi (3.86 mL, 9.64 mmol) at -78C under N2. The mixture was agitated for 2 hours at this temperature then DMF (0.83 g, 11.4 mmol) was added. The mixture was stirred at 25C for 1 hour. Quenched with NH4C1 saturate solution and extracted with EtOAc. The organic layer was dried over sodium sulfate, and concentrated in vacuo and purified using Si02 chromatography to provide compound 31d (1.8 g, 100% yield). 1H NMR (CDC13) 5: 10.03 (s, 1 H), 8.40 (s, 1 H), 8.03-8.00 (m, 2 H), 7.24-7.15 (m, 2 H)
100% To a mixture of 31c (1.56 g, 8.76 mmol) in THF (60 mL) was added a 2.5 M solution of n-BuLi (3.86 mL, 9.64 mmol) at -78C under N2. The mixture was agitated for 2 hours at this temperature then DMF (0.83 g, 11.4 mmol) was added. The mixture was stirred at 25C for 1 hour. Quenched with H4C1 saturate solution and extracted with EtOAc. The organic layer was dried over sodium sulfate, and concentrated in vacuo and purified using Si02 chromatography to provide compound 31d (1.8 g, 100% yield). 1H MR (CDC13) 5: 10.03 (s, 1 H), 8.40 (s, 1 H), 8.03-8.00 (m, 2 H), 7.24-7.15 (m, 2 H).
 

Historical Records