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Chemical Structure| 1004538-32-2 Chemical Structure| 1004538-32-2

Structure of 1004538-32-2

Chemical Structure| 1004538-32-2

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Product Details of [ 1004538-32-2 ]

CAS No. :1004538-32-2
Formula : C11H23ClN2O2
M.W : 250.77
SMILES Code : O=C(N1C[C@H](N(C)C)CC1)OC(C)(C)C.[H]Cl
MDL No. :N/A

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Application In Synthesis of [ 1004538-32-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1004538-32-2 ]

[ 1004538-32-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1004538-32-2 ]
  • [ 1004538-33-3 ]
YieldReaction ConditionsOperation in experiment
95% With sodium hydroxide; water In toluene Step 9-2:
Production of (R)-1-(tert-butoxycarbonyl)-3-dimethylaminopyrrolidine
To 1.25 g of (R)-1-(tert-butoxycarbonyl)-3-dimethylaminopyrrolidine hydrochloric acid salt (chemical purity: 99.9 areapercent) obtained in the step 9-1 were added 2.46 g of a 23percent by weight brine, 5.03 g of toluene and 738 mg of a 30percent by weight aqueous sodium hydroxide solution, and the mixture was stirred.
After conducting liquid separation, the organic layer was concentrated.
Then vacuum drying was carried out to give the title compound as 999 mg of a colorless and transparent liquid (chemical purity: 99.5 areapercent, yield 95percent).
1H-NMR (CDCl3): d (ppm) 1.46 (s, 9H), 1.74 (m, 1H), 2.05 (m, 1H), 2.24 (s, 6H), 2.63 (m, 1H), 3.05 (m, 1H), 3.27 (m, 1H), 3.45-3.69 (m, 2H)
References: [1] Patent: EP2050735, 2009, A1, . Location in patent: Page/Page column 21-22.
 

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