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Chemical Structure| 1001353-86-1 Chemical Structure| 1001353-86-1

Structure of 1001353-86-1

Chemical Structure| 1001353-86-1

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Product Details of [ 1001353-86-1 ]

CAS No. :1001353-86-1
Formula : C14H25NO4
M.W : 271.35
SMILES Code : O=C(N1[C@H](C(OCC)=O)CC(C)(C)C1)OC(C)(C)C
MDL No. :MFCD11501346
InChI Key :ZWNSAGPRRVZFDV-JTQLQIEISA-N
Pubchem ID :53487158

Safety of [ 1001353-86-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 1001353-86-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1001353-86-1 ]

[ 1001353-86-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1001353-86-1 ]
  • [ 1001353-87-2 ]
YieldReaction ConditionsOperation in experiment
91% With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20℃; 163C. (S)-4,4-Dimethylpyrrolidine-2-carboxylic acid To a solution of (S)-1-tert-butyl 2-ethyl 4,4-dimethylpyrrolidine-1,2-dicarboxylate (1.0 g, 3.7 mmol) in MeOH/H2O/THF (20/15/10 mL) was added lithium hydroxide monohydrate (0.78 g, 18.5 mmol), and the resulting mixture was stirred at room temperature overnight. The solvent was removed and the resulting residue was acidified with phosphoric acid to pH 3. The aqueous layer was extracted with EtOAc, washed with brine, dried over Na2SO4, and filtered. The filtrate was evaporated to furnish the crude product (0.82 g, 91%). 1H NMR (CD3OD, 400 MHz) δ 4.21 (m, 1H), 3.24-3.29 (m, 1H), 3.11-3.14 (m, 1H), 2.08 (m, 1H), 1.75 (m, 1H), 1.40 (s, 9H), 1.11 (s, 3H), and 1.04 (s, 3H).
 

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