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Chemical Structure| 1000771-62-9 Chemical Structure| 1000771-62-9

Structure of 1000771-62-9

Chemical Structure| 1000771-62-9

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Product Details of [ 1000771-62-9 ]

CAS No. :1000771-62-9
Formula : C10H9NO3
M.W : 191.19
SMILES Code : O=CCN1C(COC2=CC=CC=C12)=O
MDL No. :MFCD08704592

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Application In Synthesis of [ 1000771-62-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1000771-62-9 ]

[ 1000771-62-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1000771-62-9 ]
  • [ 10272-49-8 ]
  • 4-[2-(4-phenyl-piperidine-1-yl)-ethyl]-4H-benzo[1,4]oxazin-3-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
57% With borane pyridine; In ethanol; Following the procedure of Synthetic Comm. 23 (6), 789-795, 1993, to a solution of <strong>[10272-49-8]4-phenylpiperidine hydrochloride</strong> Compound 1-9 (290 mg, 1.5 mmol) and Compound 1-4 (300 mg, 1.5 mmol) in 10 mL of absolute ethanol was added BAP (154 muL, 1.5 mmol). After stirring for 2 hrs, an additional equivalent of aldehyde Compound 1-4 and BAP was added. The reaction mixture was stirred overnight and concentrated to give an oily residue. The residue was taken up in DCM, washed with saturated sodium bicarbonate solution NaHCO3 and brine, dried over Na2SO4, and concentrated. The residue was purified on silica gel (elution with 30% EtOAc in hexane) to yield Compound 86 as a glass-like oil (287 mg, 57%) of a glass-like oil. 1H NMR (300 MHz, CDCl3) delta 7.25-7.11 (m, 5H), 7.04-6.91 (m, 4H), 4.53 (s, 2H), 4.04 (m, 2H), 3.04 (m, 2H), 2.58 (m, 2H), 2.45-2.40 (m, 1H), 2.15, (t of d, J=11 and 3 Hz, 2H), 1.83-1.64 (m, 4H); MS (ES+) m/z 337.2 (M+1); Anal Calcd. for C21H24N2O2.0.51H2O: C, 73.02; H, 7.29; N, 8.11. Found: C, 72.98; H, 7.11; N, 8.00.
 

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