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Sanders, Matthew Alan ;

Abstract: Proteins are extraordinary materials that perform a variety of functions stemming from biology, such as catalysis and analyte binding. These functions originate from protein’s unique ability to form precise structures, placing residues in conformations beneficial to their function. These structures can span multiple length scales, from single molecules to assemblies of proteins. However, applications of these materials outside of native biological environments are a challenge, making industrial-scale synthesis and use of proteins often costly. Synthetic macromolecules, on the other hand, have diverse stability and functionality as well as scalable syntheses. However, the study of the hierarchical structures of synthetic macromolecules and their impact on biomimetic functions is comparatively underexplored. Catalysis is a facile method to understand how differences in polymer structure impacts functionas rates of reaction can easily be extracted from yield information to glean information about how changing polymer properties impacts the rate of catalysis. Herein we have approached the developmentof palladium bound triphenylphosphine-containing polymer catalysts and analyzed their reactivity using a model reaction modifying polymer properties such as molecular weight and comonomer (Chapter 2). Additionally, we have analyzed the addition of protein-mimetic functional groups, including local structure and electrostatic interactions, as well as incorporation of a bis-phosphine monomer to study the impact of metal-ligand cross-links on these novel polymeric materials (Chapter 3). Further, we endeavored to add strong architectural differences to these materials via the incorporation of covalent cross-linking as well as branching to study the effect of compaction and changes in backbone architecture on catalysis (Appendix A). Lastly, I have endeavored using other biomimetic materials such as peptoids and peptide-polymer amphiphiles to gain information about how the composition of these materials leads to changes in structure and therefore function through multichain assemblies (Appendix B and Appendix C respectively). Together these multifaceted approaches have enhanced our understanding of the structure-function relationships of synthetic macromolecules and have begun bridging the gap between the functionality of synthetic macromolecules and the precise hierarchical structure of biological materials.

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Product Details of 1,7-Bis-Boc-1,4,7-triazaheptane

CAS No. :117499-16-8
Formula : C14H29N3O4
M.W : 303.40
SMILES Code : CC(C)(C)OC(=O)NCCNCCNC(=O)OC(C)(C)C
MDL No. :MFCD11226825
InChI Key :KNORWRWRHNHJAV-UHFFFAOYSA-N
Pubchem ID :15157893

Safety of 1,7-Bis-Boc-1,4,7-triazaheptane

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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