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CAS No. : | 56012-38-5 |
Formula : | C5H7NOS |
M.W : | 129.18 |
SMILES Code : | OCC1=CN=C(C)S1 |
MDL No. : | MFCD12912988 |
InChI Key : | UGNOVENEUBRGNI-UHFFFAOYSA-N |
Pubchem ID : | 12808792 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 8 |
Num. arom. heavy atoms | 5 |
Fraction Csp3 | 0.4 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 1.0 |
Molar Refractivity | 33.21 |
TPSA ? Topological Polar Surface Area: Calculated from | 61.36 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 1.54 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | 0.5 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | 0.79 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | -0.47 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | 2.35 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | 0.94 |
Log S (ESOL):? ESOL: Topological method implemented from | -1.35 |
Solubility | 5.74 mg/ml ; 0.0444 mol/l |
Class? Solubility class: Log S scale | Very soluble |
Log S (Ali)? Ali: Topological method implemented from | -1.36 |
Solubility | 5.66 mg/ml ; 0.0438 mol/l |
Class? Solubility class: Log S scale | Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -1.47 |
Solubility | 4.35 mg/ml ; 0.0337 mol/l |
Class? Solubility class: Log S scale | Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -6.73 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 0.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 0.0 |
Muegge? Muegge (Bayer) filter: implemented from | 1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.55 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 2.29 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With thionyl chloride; In dichloromethane; at 0 - 20℃; for 1h; | To a stirred solution of <strong>[56012-38-5](2-methylthiazol-5-yl)methanol</strong> (2, 0.2 g, 1.55 mmol) in DCM (5 mL), was added SOCl2(0.23 mL, 3.10 mmol) drop wise at 0 C and the reaction mixture was stirred at rt for 1 h. The reaction mixture was neutralized using cold NaHC03(5 mL) solution and extracted with DCM (2 X 25 mL). Organic layer was washed with brine (5mL) solution, dried over anhydrous Na2S04 and evaporated to afford the product as yellow oil. (0.2 g, 90%, Yield). MS (ESI): Mass calcd. for C5H6C1NS , 146.99; m/z found 148.1 (M+H)+. |
87% | With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20℃; for 4h;Inert atmosphere; | To a stirred solution of compound 64 (5 g, 38.75 mmol) in CH2C12 (150 mL) under inert atmosphere were added triethyl amine (8.3 mL, 58.13 mmol), methanesulfonyl chloride (4.6 mL, 46.51 mmol) at 0 C; warmed to RT and stirred for 4 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was diluted with water (50 mL) andextracted with CH2C12 (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford compound 65 (5 g, 87%) as a pale-yellow syrup. TLC: 30% EtOAc/ hexanes (Rf: 0.8); LC-MS: 77.92%; 147.7 (M+1) (column; Ascentis Express C18, (50 x 3.0 mm, 2.7 jim); RT 1.71 mm. 0.025% Aq. TFA + 5% ACN: ACN + 5% 0.025% Aq. TFA, 1.2 mL/min). |
82.32% | With thionyl chloride; In dichloromethane; for 4h; | (2-methylthiazol-5-yl) methanol (304 mg, 2.35 mmol) and thionyl chloride (0.9 mL,10mmol) was dissolved in dichloromethane (15mL), the reaction 4h. The reaction mixture was poured into water (30 mL) and extracted with ethyl acetate (30 mL × 3)The residue was washed with saturated brine (15 mL) and dried over anhydrous sodium sulfate. The solvent was removed and the residue was subjected to column chromatography (eluent: PE /EtOAc (v / v) = 10/1) to give 286 mg of a light yellow oil, yield: 82.32%. |
With thionyl chloride; In dichloromethane; at 0℃;Inert atmosphere; | To a solution of <strong>[56012-38-5](2-methylthiazol-5-yl)methanol</strong> (1 eq) in DCM (10 mL) at 0C under N2 was added thionyl chloride (3 eq), dropwise. The reaction mixture was stirred at 0C for 2h. The reaction progress was monitored by TLC. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to afford 5-(chloromethyl)-2- methylthiazole as a brown liquid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃; for 16.25h;Inert atmosphere; | To a stirred suspension of lithium aluminium hydride (3.1 g, 93.56 mmol) in dry THF (10 mL) under inert atmosphere was added compound 63 (8 g, 46.78 mmol) in dry THF (50 mL) dropwise for 15 mm at 0 °C; warmed to RT and stirred for 16 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was cooled to 0 °C, quenched with15percent aqueous sodium hydroxide solution (10 mL), filtered through celite and washed withEtOAc (3 x 100 mL). The filtrate was dried over sodium sulfate, filtered and concentrated invacuo to afford compound 64 (5 g, 83percent) as an off-white solid. TLC: 50percent EtOAc/ hexanes (Rf:0.3). LC-MS: 97.32percent; 130.22 (M+1) (column; X-select CSH C18, (50 x 3.0 mm, 2.5 jim); RT0.65 mm. 2.5 mM Aq. NH4OAc: ACN: 0.8 mL/min). |
78% | In chloroform; | B. 5-(Hydroxymethyl)-2-methylthiazole Using the procedure of Example 1P, but replacing ethyl thiazole-5-carboxylate with crude ethyl 2-methylthiazole-5-carboxylate provided, after silica gel chromatography using 3percent then 5percent methanol in chloroform, the desired compound, Rf 0.27, (4percent methanol in chloroform) in 78percent yield. 1 H NMR (CDCl3)delta2.32 (br, 1H), 2.70 (s, 3H), 4.80 (s, 2H), 7.46 (s, 1H). Mass spectrum: (M+H)+ =130. |
Step 1: Intermediate 15-a To a solution of ethyl 2-methylthiazole-5-carboxylate (5.82 g, 34.0 mmol) in THF (170 ml), cooled to 0 °C, was added a 1.0M solution of LiAIH4 in THF (34.0 ml, 34.0 mmol) and the reaction was slowly warmed to room temperature and stirred overnight. Water (1.3 ml) was slowly added, followed by 15percent NaOH (1.3 ml_). The solution was stirred for 2 hours at room temperature then filtered over celite. The filtrate was concentrated under reduced pressure to provide intermediate 15-a as a yellow oil. |
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃; for 2h; | To a solution of intermediate 7-c (22.2 g, 130.0 mmol) in THF (430 ml) cooled to 0°C was added a 1.0 M solution LiAIH4 in THF (91.0 ml, 91.0 mmol). The solution was slowly warmed to room temperature and stirred for 2 hours. Water (3.5 ml) was slowly added, followed by 3.5 ml 15percent NaOH (3.5 ml) and water (10.5 ml) and the mixture was stirred for 1 hour. The reaction was filtered through celite and the filtrate collected. Volatiles were removed in vacuo to provide intermediate 7-d as a yellow oil. | |
Step 3: Intermediate 5-d; To a solution of intermediate 5-c (22.2 g, 130.0 mmol) in THF (430 ml) cooled to 0°C was added a 1.0 M solution LiAIH4 in THF (91.0 ml, 91.0 mmol) and the solution was slowly warmed to room temperature and stirred for 2 hours. Water (3.5 ml) was slowly added, followed by 3.5 ml lSpercent NaOH (3.5 ml) and water (10.5 ml) and the mixture was stirred for 1 hour. The reaction was filtered over celite and volatiles were removed under reduced pressure to provide intermediate 5-d as yellow oil. | ||
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃;Inert atmosphere; | To a stirred solution of ethyl 2-methylthiazole-5-carboxylate (1 eq) in dry THF (5 mL) at 0 <C ) under N2 was added LiAIH4 (1 .1 eq., 2.0 M solution in THF) dropwise. The reaction mixture was stirred at RT for 1 h. The reaction progress was monitored by TLC. After completion of the reaction, the reaction mixture was cooled to -10°C to 0 < and then quenched by the dropwise addition of 10percent NaOH aqueous solution (5 mL). After 10 min of stirring, the mixture was filtered through a pad of Celite and the filtrate was concentrated under reduced pressure to afford (2-methylthiazol-5-yl)methanol (6 g) as a pale yellow solid. The crude product used in the next step without purification. LC/MS: (Method A) 130.0 (M+H). H NMR (DMSO-de, 400 MHz): delta 7.4 (s, 1 H), 5.5 (s, 1 H), 4.6 (d, J = 4.0 Hz, 2H), 2.6 (s, 3H). | |
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃; for 2h; | Step 4: Intermediate 29-d [0172] To a solution of intermediate 29-c (22.2 g, 130.0 mmol) in THF (430 ml) cooled to 0° C. was added a 1.0 M solution of LiAlH4 in THF (91.0 ml, 91.0 mmol) and the solution was slowly warmed to room temperature and stirred for 2 hours. Water (3.5 ml) was slowly added, followed by 3.5 ml 15percent NaOH (3.5 ml) and water (10.5 ml) and the mixture was stirred for 1 hour. The reaction was filtered over celite and volatiles were removed in vacuo to provide intermediate 29-d as yellow oil. | |
12g | With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃; for 18h; | Step 1: Synthesis of 2-methyl-5-hydroxymethylthiazole: At room temperature, lithium aluminum hydride (8.88g, 234mmol) was dispersed in anhydrous tetrahydrofuran (THF, 100mL). The resulting mixture was cooled to 0-5°C in an ice-water bath. To the cooled mixture was dropwise added a solution of 2-methyl-5-ethoxyformylthiazole (20g,117mmol) in anhydrous tetrahydrofuran (THF, 100mL). After the completion of the dropwise addition, the reaction mixture was naturally warmed to room temperature, and was stirred for 18 hours at room temperature. To the reaction mixture was dropwise added water (10mL) at 0-5°C. After the completion of the dropwise addition, the resulting mixture was filtered. The filtrate was concentrated to produce a yellow oily substance (12g), which was directly used in the next step. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | 5-(Azidomethyl)-2-methylthiazole. A solution of <strong>[56012-38-5](2-methylthiazol-5-yl)methanol</strong> (3.99 g, 30.9 mmol) in tetrahydrofuran (100 ml) was cooled to 0 C. and treated with methanesulfonyl chloride (2.40 ml, 30.9 mmol) followed by triethylamine (4.3 ml, 30.9 mmol) added dropwise over 10 min. The resulting mixture was stirred for 20 min, diluted with N,N-dimethylformamide (50 ml) and then treated with sodium azide (3.20 g, 49.2 mmol). After 18 h at 22 C., the reaction mixture was diluted with ethyl acetate, washed with saturated sodium bicarbonate, brine and dried over anhydrous magnesium sulfate. Evaporation of the solvent under reduced pressure followed by chromatography of the residue on silica gel (elution toluene-ethyl acetate 0-20%) gave 4.42 g (92% yield) of the title azide as a clear oil. 1HNMR 400 MHz (CDCl3) delta (ppm) : 2.74 (3H, s, CH3), 4.50 (2H, s, CH2), 7.56 (1H, s, CH). MS (ESI+) m/e 155 [M+H+]. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water; ethyl acetate; isopropyl alcohol; | EXAMPLE 2 2-methyl-5-[(N,N-dimethylcarbamoyloxy)-methyl]-thiazole hydrochloride A mixture of 50 ml of deperoxidized and anhydrous tetrahydrofuran and 1.9 g of sodium hydride suspended in oil was stirred and then 5.2 g of 2-methyl-5-hydroxymethyl-thiazole were added thereto followed by 8.8 g of dimethylcarbamic acid chloride while holding the temperature between 15 and 20 C. The mixture was stirred for 4 hours at room temperature and was vacuum filtered. The filter was washed with tetrahydrofuran and the filtrate was evaporated to dryness under reduced pressure. The residue was taken up in water and the aqueous phase was washed with ethyl ether. The ether extracts were dried over magnesium sulfate and evaported to dryness to obtain 10 g of raw product which was dissolved in ethyl acetate. The pH of the solution was adjusted to 1 with ethyl acetate saturated with hydrochloric acid and the mixture was vacuum filtered. The recovered crystals were washed with ethyl acetate and dissolved in 50ml of refluxing isopropanol. The solution was iced and vacuum filtered and the product was dried to obtain 6.8 g of 2-methyl-5-[N,N-dimethylcarbamoyloxy)-methyl] -thiazole hydrochloride melting at 130 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In tetrahydrofuran; ethyl acetate; | EXAMPLE 3 2-methyl-5-(N-phenylcarbamoyloxymethyl)-thiazole hydrochloride A mixture of 2.6 g of 2-methyl-5-hydroxymethyl-thiazole, 2.6 g of phenyl isocyanate, 26 ml of anhydrous tetrahydrofuran and 1 ml of triethylamine was refluxed for one hour, cooled to room temperature and then evaporated to dryness under reduced pressure. The residue was dissolved in hot ethyl acetate and the solution was added to ethyl acetate saturated with hydrochloric acid. The mixture was filtered and the crystals were dried to obtain 5 g of crystals which were crystallized from ethanol to obtain 3.2 g of 2-methyl-5-(N-phenylcarbamoyloxy-methyl)-thiazole hydrochloride melting at 160 C. Analysis: C12 H13 N2 O2 SCl Calculated: %C, 50.60; %H, 4.60; %N, 9.83; %Cl, 12.44; %S, 11.25; Found: %C, 50.5; H, 4.6; N, 9.8; Cl, 12.7; S, 11.2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
STEP B: 2-methyl-5-[(N-methylcarbamoyloxy)-methyl]-thiazole A mixture of 3.85 g of <strong>[56012-38-5]2-methyl-5-hydroxymethylthiazole</strong> and 10 ml of methyl isocyanate stood for 24 hours and was then evaporated to dryness. The oily residue was chromatographed over silica gel and elution with a 3-7 benzene-ethyl acetate mixture yielded 5.03 g of product. The product was crystallized from a methylene chloride-isopropyl ether mixture to obtain 4.16 g of 2-methyl-5-[(N-methylcarbamoyloxy)-methyl] -thiazole in the form of colorless crystals melting at 80 C. Analysis: C7 H10 N2 O2 S Calculated: %C, 45.14; %H, 5.41 %N, 15.04; %S, 17.21; Found: %C, 45.2; H, 5.5; N, 15.0; S, 17.2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In tetrahydrofuran; methanol; ethyl acetate; | STEP A 2-methyl-5-hydroxymethyl-thiazole 2.54 g of lithium aluminum hydride were added at 20-25 C. under a nitrogen atmosphere to a solution of 10.5 g of methyl 2-methyl-5-thiazolecarboxylate in 105 ml of anhydrous tetrahydrofuran and the mixture was refluxed for one hour and then cooled. Addition of ethyl acetate and then methanol destroyed excess hydride and the mixture was filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica gel to obtain 7.6 g of product which was crystallized from isopropyl ether to obtain 5.28 g of 2-methyl-5-hydroxymethyl-thiazole melting at 50 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; | Step 7: Intermediate 29-h To a solution of intermediate 29-g (8.0 g, 33.1 mmol) and intermediate 29-d (4.70 g, 36.4 mmol) in THF (20 ml) were sequentially added triphenylphosphine (12.15 g, 46.3 mmol) and DIAD (9.0 ml, 46.3 mmol) at room temperature and the reaction was then stirred at room temperature overnight. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided intermediate 29-h as a yellow oil. | |
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 1h; | To a solution of intermediate 8-c (1.0 g, 105.0 mmol) and intermediate 7-d (352 mg, 2.73 mmol) in THF (20 ml) were sequentially added triphenylphosphine (1.07 g, 4.1 mmol) and DIAD (796 p1, 4.1 mmol) at room temperature. The reaction was then stirred at room temperature for 1 hour. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided intermediate 8-d as a yellow oil. | |
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 1h; | Step 6: Intermediate 5-h: To a solution of intermediate 5-g (1.0 g, 105.0 mmol) and intermediate 5-d (352 mg, 2.73 mmol) in THF (20 ml) were sequentially added triphenylphosphine (1.07 g, 4.1 mmol) and DIAD (796 p1, 4.1 mmol) at room temperature and the reaction was then stirred at room temperature for 1 hour. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided intermediate 5-h as yellow oil. |
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; | Step 7: Intermediate 29-h [0175] To a solution of intermediate 29-g (8.0 g, 33.1 mmol) and intermediate 29-d (4.70 g, 36.4 mmol) in THF (20 ml) were sequentially added triphenylphosphine (12.15 g, 46.3 mmol) and DIAD (9.0 ml, 46.3 mmol) at room temperature and the reaction was then stirred at room temperature overnight. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided intermediate 29-h as a yellow oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 18h; | Step 2: Intermediate 15-b To a solution of intermediate 15-a (7.75 g, 34.5 mmol) and intermediate 11- a (4.25 g, 32.9 mmol), in THF (33 ml_), were sequentially added triphenylphosphine (10.35 g, 39.5 mmol) and DIAD (7.68 ml, 39.5 mmol) drop wise at room temperature. The reaction was then stirred for 18 hours. Volatiles were removed in vacuo. Purification by silica gel chromatography provided intermediate 15-b as a colorless oil. | |
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 18h; | Step 2: Intermediate 15-b [0132] To a solution of intermediate 15-a (7.75 g, 34.5 mmol) and intermediate 11-a (4.25 g, 32.9 mmol), in THF (33 mL), were sequentially added triphenylphosphine (10.35 g, 39.5 mmol) and DIAD (7.68 ml, 39.5 mmol) drop wise at room temperature. The reaction was then stirred for 18 hours. Volatiles were removed in vacuo. Purification by silica gel chromatography provided intermediate 15-b as a colorless oil. |
Tags: 56012-38-5 synthesis path| 56012-38-5 SDS| 56012-38-5 COA| 56012-38-5 purity| 56012-38-5 application| 56012-38-5 NMR| 56012-38-5 COA| 56012-38-5 structure
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P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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