(R)-α-Methyl-4-nitrobenzylamine HCl | Benzene Compounds

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of (R)-α-Methyl-4-nitrobenzylamine HCl Purity: 97% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of (R)-α-Methyl-4-nitrobenzylamine HCl

CAS No. :	57233-86-0
Formula :	C₈H₁₁ClN₂O₂
M.W :	202.64
SMILES Code :	N[C@H](C)C1=CC=C([N+]([O-])=O)C=C1.[H]Cl
MDL No. :	MFCD00066311
InChI Key :	CZQQGVFHLSBEDV-FYZOBXCZSA-N
Pubchem ID :	16212177

Safety of (R)-α-Methyl-4-nitrobenzylamine HCl

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of (R)-α-Methyl-4-nitrobenzylamine HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 57233-86-0 ]

[ 57233-86-0 ] Synthesis Path-Downstream 1~30

1
[ 50-00-0 ]
[ 57233-86-0 ]
[ 542-92-7 ]
(+)-(1S,1'R)-2-<1'-(4''-Nitrophenyl)ethyl>-2-azabicyclo<2.2.1>hept-5-ene [ No CAS ]
(-)-(1R,1'R)-2-<1'-(4''-Nitrophenyl)ethyl>-2-azabicyclo<2.2.1>hept-5-ene [ No CAS ]

References: [1]Helvetica Chimica Acta,1993,vol. 76,p. 1203 - 1215.

2
[ 57233-86-0 ]
1-tert-Butyl-8-chloro-6-(2-fluoro-phenyl)-4H-2,5,10b-triaza-benzo[e]azulene-3-carbonyl chloride [ No CAS ]
<R>-(-)-(R)-8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-N-(4-nitro-1-phenylethyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide [ No CAS ]

References: [1]Journal of Organic Chemistry,1993,vol. 58,p. 3285 - 3298.

3
[ 57233-86-0 ]
[ 159596-55-1 ]
4-{2-[(R)-1-(4-Nitro-phenyl)-ethylamino]-3,4-dioxo-cyclobut-1-enylamino}-benzonitrile [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 1187 - 1202.

4
[ 24424-99-5 ]
[ 57233-86-0 ]
[ 694529-38-9 ]

Yield	Reaction Conditions	Operation in experiment
94.38%	With sodium hydrogencarbonate; In dichloromethane; water; for 3h;	Step 1 : Synthesis of (i?)-[l-(4-Nitrophenyl)ethyl]carbamic acid t-butyl ester; (Ri3= Me)(i?)-methyl-4-nitrobenzylaminehydrochloride (50mg, 0.25mmol) was put into 25ml of flask and dissolved in the saturated solution (NaHCO3 : CH2Cl2 = 1:1). To the solution was added di-t-butyl dicarbonate (135mg, 0.60mmol), followed by stirring for 3 hours. The reacting mixture was diluted with methylene chloride, washed with water and brine, dried over Na2SO4 and concentrated under reduced pressure. The obtained liquid was purified by column chromatography (n-hexane/ethyl acetate = 10/1) to yield EPO <DP n="61"/>pale yellow liquid (62.0 mg, 94.38%).[alpha]D22: -43.66(C LSS3 CHCl3);IR (NaCl, neat, cm"1): 3403, 3332, 2977, 2932, 1697, 1522, 1347; 1H NMR (400MHz, CDCl3): 8.20 (d, 2H, J=8.8Hz), 7.47 (d, 2H, J = 8.8 Hz), 4.91 (s, IH), 4.85 (s, IH), 1.46 (d, 3H, J= 6.8 Hz), 1.42 (s, 9H)
92%	With sodium hydrogencarbonate; In dichloromethane; at 25℃; for 24h;	Step 1: Preparation of (R)-tert-butyl 1-(4-nitrophenyl)ethylcarbamate (C1) (R)-1-(4-nitrophenyl)ethanamine hydrochloride salt (1.0 g, 4.9 mmol), tert-butoxycarbonyl (BOC) anhydride (1.18 g, 5.43 mmol), and 10.0 mL of 1M sodium bicarbonate solution were dissolved in DCM (15 mL) and allowed to stir at 25 C. for 24 h. The organic layer was collected, and the aqueous layer was washed with DCM. The combined organic layers were then washed with water and 0.1N HCl, dried over MgSO4, filtered, and concentrated to provide C1 as a white solid. Yield: 1.2 g, 92%. GC-MS=266. 1H NMR (500 MHz, d6-DMSO) delta: 8.15 (d, 2H), 7.56 (d, 1H), 7.52 (d, 2H), 4.68 (m, 1H), 1.32 (s, 9H), 1.27 (d, 3H).

References: [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 1751 - 1755.
[2]Patent: WO2006/98554,2006,A1 .Location in patent: Page/Page column 59-60.
[3]Patent: US2009/54395,2009,A1 .Location in patent: Page/Page column 47.

5
[ 878548-90-4 ]
[ 13094-51-4 ]
[ 57233-86-0 ]
(S)-(-)-α-methyl-4-nitrobenzylamine hydrochloride [ No CAS ]
di-tert-butyl 4-aminobutylphosphonateN¹-tert-butoxycarbonyltryptamine [ No CAS ]
C₈₄H₁₀₉N₁₇O₂₆P₂S [ No CAS ]

References: [1]Journal of the American Chemical Society,2006,vol. 128,p. 1995 - 2004.

6
[ 31088-81-0 ]
[ 57233-86-0 ]
[ 694529-13-0 ]

Yield	Reaction Conditions	Operation in experiment
98%	With triethylamine; In dichloromethane; at 20℃;	To a stirred solution of (R or S)-alpha-METHYL-4-NITROBENZYL amine hydrochloride (203 mg, 1 mmol) in anhydrous CH2C12 (10 mL) was added triethylamine (0.28 mL, 2 mmol) at room temperature. When the reaction mixture became clear, isothiocyanate (1 mmol) was added and stirred OVERNIGNT at room temperature. The mixture was evaporated by rotary evaporator and the residue was purified by flash column chromatography on silica gel with EtOAc: hexanes as eluant to N-(4-T-BUTYLBENZYL)-N -F (1R)-1- [4- (methylsulfonylamino) phenyl] ethyl} thiourea (16-5, SU-388). 98% yield, a sticky colorless oil IH NMR (CDC13) 6 8.12 (d, 2 H, J= 8.76 Hz), 7.34 (bd, 4 H), 7.14 (d, 2 H, J= 8.0 Hz), 6.21 (bs, 2 H), 5.37 (bs, 1 H), 4.54 (M, 2 H), 1.47 (d, 3 H, J= 7. 05 HZ), 1.30 (s, 9 H)

References: [1]Patent: WO2005/3084,2005,A1 .Location in patent: Page 27; 85-86.
[2]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 6043 - 6053.

7
[ 57233-86-0 ]
[ 65645-32-1 ]