The BRCA family primarily includes two major members, BRCA1 and BRCA2, whose proteins feature structural domains like the RING finger and BRCT, essential for DNA repair. These proteins are predominantly located in the nucleus, involved in critical DNA repair processes such as homologous recombination, crucial for maintaining genomic stability. BRCA genes are expressed in various tissues, particularly in the breast and ovaries, showing high tissue specificity. Mutations are commonly associated with a high risk of hereditary breast and ovarian cancers.