Home Chemistry Organic Building Blocks Trifluoromethyls 4-(Trifluoromethoxy)Aniline
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —OCF3,—NH2).
Cross-Coupling Reactions: Trifluoromethoxybenzene can be used as a substrate in various cross-coupling reactions, such as Suzuki-Miyaura coupling, Heck coupling, or Buchwald-Hartwig amination. These reactions can introduce various substituents onto the benzene ring.
Reimer-Tiemann Reaction: Aniline can react with chloroform (CHCl3) and a base to undergo the Reimer-Tiemann reaction, leading to the formation of a salicylaldehyde derivative.
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4-(Trifluoromethoxy)-2-(trifluoromethyl)aniline hydrochloride
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4-(Trifluoromethoxy)-3-(trifluoromethyl)aniline
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