Home Products Cited in Publications Worldwide Iridium-catalyzed allylic fluorination: Scope, mechanism, and application
Mixdorf, Jason Craig
Allylic fluorides are ubiquitous scaffolds in pharmaceuticals, agrochemicals, materials chemistry, and positron emission tomography (PET) imaging. Recently, it has been shown that transition metal complexes can catalyze the formation of allylic carbon-fluoride bonds. This dissertation describes the development of a new procedure for the synthesis of enantioenriched allylic fluorides utilizing an iridium complex as the catalyst. A detailed study using both computational and laboratory experiments was conducted leading to insights about this unique mechanism of the iridium-catalyzed allylic fluorination reaction. Additionally, the allylic fluorination methodology was translated for the production of allylic [18F]fluorides for potential use as radiotracers for qualitative and quantitative assessment of disease state.