Products Cited in Publications Worldwide Effect of Celecoxib Alone or in Combination of Sitagliptin in Monoiodoacetate Rat Model of Osteoarthritis

Effect of Celecoxib Alone or in Combination of Sitagliptin in Monoiodoacetate Rat Model of Osteoarthritis

Al-Uqabi; Rabab Utba; Al-Gareeb; Ali I.; Al-Buhadily; Ali K.

DOI:

Abstract

Background: Osteoarthritis (OA) is considered an attractive research issue; as it is the most common musculoskeletal progressive condition with no cure yet. Aims: To evaluate effect of celecoxib alone or in combination of sitagliptin in monoiodo acetate rat model of OA. Methods: A total of 40 Sprague-Dawley male rats were divided into 4 groups, negative control (n=10), positive control group (OA induced by monoiodoacetate (MIA)) (n=10), celecoxib 50mg/kg (n=10), and celecoxib 50mg/kg plus sitagliptin 20mg/kg group (n=10). Serum levels of inflammatory biomarkers and serum CTX-II were assessed for all groups. Data were analyzed statistically by SPSS version 28.00. Results: group treated with celecoxib showed a significant reduction in the inflammatory biomarkers and CTX-II serum levels compared with the OA group (P<0.01). A significant reduction in CTX-II level in combination treated group relative to celecoxib treated group. Conclusion: Celecoxib imparted anti-inflammatory and cartilage protective effect in OA induced rat model. Sitagliptin combination with celecoxib added an extra cartilage protective effect by reducing cartilage degradation evident by lowering CTX-II serum levels.

Keywords

Celecoxib ; CTX-II ; osteoarthritis

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Sodium iodoacetate

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Sodium iodoacetate

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