Products Cited in Publications Worldwide A comprehensive approach to transdermal drug delivery through the skin: Ibuprofen derivatives in semi-solid formulations

A comprehensive approach to transdermal drug delivery through the skin: Ibuprofen derivatives in semi-solid formulations

Karolina Bilska; Anna Nowak; Anna Story; Grzegorz Story; Wiktoria Duchnik; Łukasz Kucharski; Paula Elżbieta Ossowicz-Rupniewska

DOI:

Abstract

This article presents a comprehensive study on the formulation andevaluation of pharmaceutical emulsions for topical drug delivery. Theresearch focused on emulsions containing ibuprofen and its derivatives(sodium and L-lysine propyl ester salts), investigating their solubility,consistency, stability, and skin permeation. The study offers valuableinsights into the development of effective pharmaceutical products.Background.Transdermal and topical drug delivery is a promisingapproach for the treatment of various medical conditions.Pharmaceutical emulsions provide an ideal platform for deliveringactive substances through the skin. The selection of emulsioningredients, consistency, and stability play a critical role in determiningthe suitability of these formulations. Aim of the study: The primary aim of this study was to formulate andevaluate pharmaceutical emulsions containing ibuprofen and otheractive substances. Key objectives included assessing the solubility,consistency, stability, and skin permeation characteristics of theemulsions. The study aimed to provide insights into the development ofeffective topical drug delivery systems. Material and methods: olubility tests were conducted to selectsuitable emulsion ingredients. Various emulsions were prepared withdifferent water-to-oil phase ratios. Rheology modifiers were added toenhance consistency. Quality control assessments were performedincluding uniformity, consistency, stability, density, viscosity, andparticle size analysis. The release of active substances from theformulations and their penetration and accumulation in the skin weredetermined. Results: The results revealed variations in viscosity, consistency, andstability among different formulations. Emulsion-based preparationsdemonstrated the highest accumulation of active substances in theskin, with formulation F1 (5294.617 yg/g skin) exhibiting the mostpromising results. The highest release of ibuprofen was observed inthe formulation based on Celugel with the addition of[LysOPr lBU (F6-approximately 7750 yg lBU/cm2, and the highest penetration of theactive substance was obtained for the emulsion with the addition ofIBU.Na (F2)-3300 yg lBU/cm2 after 24 hours of testing.Conclusion. This comprehensive study on pharmaceutical emulsionsfor topical drug delivery provides critical insights into the formulationand evaluation of cosmetic and pharmaceutical products. The findingshighlight the importance of ingredient selection, consistency, andstability in the development of effective emulsion-based formulationsFurthermore, the study suggests that emulsion-based preparationshave potential for topical applications, especially for more hydrophilicactive substances. Future research can build on these results toenhance drug delivery systems and improve patient outcomes.

Keywords

ibuprofen ; ibuprofenates of L-amino acid alkyl esters ; semi-solid pharmaceutical formulations ; skin permeability

Purchased from AmBeed

Ibuprofen

A23870215687-27-198%

Ibuprofen

10.0/1mg

Detail