Products Cited in Publications Worldwide A Dual Catalytic Approach for the Halogen-Bonding-Mediated Reductive Cleavage of α-Bromodifluoroesters and Amides

A Dual Catalytic Approach for the Halogen-Bonding-Mediated Reductive Cleavage of α-Bromodifluoroesters and Amides

Tasnim, Tarannum; Shafiei, Negin; Laminack, Katelyn; Robertson, Bailey; Nevels, Nash; Fennell, Christopher; Pitre, Spencer

DOI:

Abstract

While charge-transfer complexes involving halogen-bonding interactions have emerged as an alternative strategy for the photogeneration of carbon radicals, examples using (fluoro)alkyl bromides are limited. This report describes adual catalytic approach for radical generation from α-bromodifluoroesters and amides under visible light irradiation. Mechanistic studies suggest that the reaction proceeds through in-situ bromide displacement using a catalytic iodide salt, generat_x005f_x0002_ing a C–I bond that can be engaged by our halogen-bonding photocatalysis platform.

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