Products Cited in Publications Worldwide Estrogen counteracts age-related decline in beige adipogenesis through the NAMPT-regulated ER stress response

Estrogen counteracts age-related decline in beige adipogenesis through the NAMPT-regulated ER stress response

Jooman Park; Ruoci Hu; Yanyu Qian; Shaolei Xiong; Asma Sana El-Sabbagh; Meram Ibrahim; Jaden Wang; Ziqiao Xu; Zhengjia Chen; Qing Song; Zhenyuan Song; Gege Yan; Abeer M. Mahmoud; Yanlin He; Brian T. Layden; Jiwang Chen; Sang-Ging Ong; Pingwen Xu; Yuwei Jiang

DOI: PMID:

Abstract

Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages that they offer are compromised with aging. Here we show that treating mice with (E2), a hormone that decreases with age, can counteract the age-related decline in beige adipogenesis when exposed to cold temperature while concurrently enhancing energy expenditure and improving tolerance in mice. Mechanistically, we found that phosphoribosyl (NAMPT) plays a pivotal role in facilitating the formation of E2-induced beige adipocytes, which subsequently suppresses the onset of age-related endoplasmic reticulum (ER) stress. Furthermore, we found that targeting signaling, either genetically or pharmacologically, can restore the formation of beige adipocytes by increasing the number of perivascular adipocyte progenitor cells. Conversely, the absence of signaling prevents this process. Together, our findings shed light on the mechanisms regulating the age-dependent impairment of beige adipocyte formation and underscore the E2-NAMPT-controlled ER stress pathway as a key regulator of this process.

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