Home Products Cited in Publications Worldwide Quinolone-3-amidoalkanol: A New Class of Potent and Broad-Spectrum Antimicrobial Agent
ACS Omega,2023,8(19):17086-17102.
Dube, Phelelisiwe S.; Angula, Klaudia T.; Legoabe, Lesetja J.; Jordaan, Audrey; Boitz Zarella, Jan M.; Warner, Digby F.; Doggett, J. Stone; Beteck, Richard M.
DOI:10.1021/acsomega.3c01406 PMID:37214682
Herein, we describe 39 novel quinolone compounds bearing a hydrophilic amine chain and varied substituted benzyloxy units. These compounds demonstrate broad-spectrum activities against acid-fast bacterium, Gram-pos. and -neg. bacteria, fungi, and leishmania parasite. Compound 30 maintained antitubercular activity against moxifloxacin-, isoniazid-, and rifampicin-resistant Mycobacterium tuberculosis, while 37 exhibited low micromolar activities (<1 μg/mL) against World Health Organization (WHO) critical pathogens: Cryptococcus neoformans, Acinetobacter baumannii, and Pseudomonas aeruginosa. Compounds in this study are metabolically robust, demonstrating % remnant of >98% after 30 min in the presence of human, rat, and mouse liver microsomes. Several compounds thus reported here are promising leads for the treatment of diseases caused by infectious agents.