Products Cited in Publications Worldwide Development of an acrylic acid-functionalized molecularly imprinted polymeric material for chiral recognition of S-ketamine

Development of an acrylic acid-functionalized molecularly imprinted polymeric material for chiral recognition of S-ketamine

Alharbi, Hussam Y.; Aljohani, Majed S.; Monier, M.

DOI:

Abstract

This study details the chiral identification of S-ketamine and the successful optical resolution of the racemic mixture of (±)-ketamine. The study outlines the development of a stereo-selective polymer material that is constructed using a crosslinked copolymer of 4-vinylphenol and acrylic acid. The initial step involved the synthesis of a chiral monomer precursor derived from S-ketamine and acryloyl chloride, which was then subjected to elemental anal., Fourier transform IR (FTIR), and NMR (NMR) spectroscopy for anal. The amide derivative was free-radical copolymerized with 4-vinylphenol and divinylbenzene, and the resulting polymer resin was treated with alkali and then acid to break the amide linkage and get the S-ketamine out of the polymeric material. FTIR spectra and SEM were used to characterize the resulting molecularly imprinted polymer, and the material was tested for its ability to selectively remove S-ketamine under a range of conditions. Adsorption followed the Langmuir model with a maximum capacity of 137 ± 1 mg/g, and the findings showed that the optimum adsorption occurred at pH 7. Also, the optical resolution was performed using a column, with estimated enantiomeric excess values of 96% for R-ketamine and 81% for S-ketamine in the loading and recovery solutions

Keywords

Molecular-imprinting ; Ketamine enantiomers ; Chiral separation

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4-Vinylphenol

A3026732628-17-310 wt.% In propylene glycol

4-Vinylphenol

436.0/500g

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