Klebeko, Joanna; Ossowicz-Rupniewska, Paula; Nowak, Anna; Kucharska, Edyta; Kucharski, Lukasz; Duchnik, Wiktoria; Struk, Lukasz; Klimowicz, Adam; Janus, Ewa

DOI:

Abstract

Herein, we investigated the effect of pairing the L-amino acid alkyl (Pr, iso-Pr, or butyl) ester on the formation of API-ILs. The novel salts of NSAIDs (non-steroidal anti-inflammatory drugs) obtained from biodegradable cations were synthesized and characterised by NMR (NMR), Fourier transform IR spectroscopy (FT-IR), and X-ray powder diffraction (XRD) methods. The influence of structure counterions for APIs from the NSAIDs group on their physicochem. properties was studied in detail. The comprehensive effects of cation structure on skin permeation, accumulation, and antioxidant activity of API-ILs were also evaluated. These results demonstrated that L-amino acid alkyl esters can be successfully used to synthesize API-ILs further used in topical formulations with anti-ageing, anti-inflammatory, or photoprotective effects.

Keywords

Nonsteroidal anti-inflammatory drug ; Amino acid ester salts ; Ionic liquids ; Topical delivery ; Skin barrier

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