Products Cited in Publications Worldwide Facile Synthesis of MOF-Derived Graphitic Carbon-Decorated NiVO4 as an Ultra-Sensitive Electrochemical Sensor for Non-enzymatic Detection of Sarcosine

Facile Synthesis of MOF-Derived Graphitic Carbon-Decorated NiVO4 as an Ultra-Sensitive Electrochemical Sensor for Non-enzymatic Detection of Sarcosine

Rasheed, Sufian; Ikram, Muhammad; Fatima, Batool; Alomayri, Thamer; Hussain, Dilshad

DOI:

Abstract

Selective and sensitive detection of sarcosine biomarkers is highly important in early-stage prostate cancer diagnosis. Sarcosine is a promising biomarker present in urine and plasma samples that can be monitored effectively by biosensors. The work presents a novel metal-organic framework (MOF)-derived GC@NiVO4 composite for non-enzymatic sarcosine detection, a promising prostate cancer biomarker. This newly designed composite was synthesized through a multi-step process involving the preparation of a Ni-BDC MOF, followed by vanadium doping (V@NiBDC-MOF) and calcination to obtain the MOF-derived graphitic carbon-decorated NiVO4 composite (GC@NiVO4). Characterization results confirmed the porous graphitic carbon, with NiVO4 embedded within the graphitic carbon matrix. This unique composition offers an exceptional surface for effective analyte adsorption in electrochemical sensing applications. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and chronoamperometry were employed to quantify the sarcosine in order to evaluate the detection capabilities. The GC@NiVO4-based sensor exhibited an impressive limit of detection (LOD) of 0.03 µM and a limit of quantification (LOQ) of 0.1 µM, surpassing the sensitivity of enzymatic-based detection sensors currently available for sarcosine. Practical applicability was assessed through recovery experiments in real urine samples. The developed composite demonstrated a 95–105 % recovery, highlighting its potential for clinical utilization in prostate cancer diagnosis and monitoring. Moreover, the sensor exhibited excellent stability, maintaining reliable performance for up to 100 cycles of sarcosine detection, showcasing its robustness and durability for repeated use. Additionally, reproducibility was confirmed by detecting sarcosine in three cycles, consistently yielding accurate results.

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