Products Cited in Publications Worldwide A comparative metabolomics analysis of Açaí (Euterpe oleracea Mart.) fruit, food powder, and botanical dietary supplement extracts

A comparative metabolomics analysis of Açaí (Euterpe oleracea Mart.) fruit, food powder, and botanical dietary supplement extracts

Heck, Kabre L; Yi, Yuyan; Thornton, Destini; Zheng, Jingyi; Calderón, Angela I

DOI: PMID:

Abstract

Introduction: Euterpe oleracea Mart. (açaí) is a botanical of interest to many who seekfunctional foods that provide and anti-inflammatory properties. Cancerpatients are increasingly taking botanical dietary supplements containing açaí to com-plement their conventional therapeutics, which may lead to serious adverse events.Before testing our açaí extracts in vitro for botanical-drug interactions, the goal is tochemically characterize our extracts for compounds whose biological activity in açaíis unknown.Objective: The objective of this work was to develop a chemical fingerprintingmethod for untargeted characterization of açaí samples from a variety of sources,including food products and botanical dietary supplement capsules, made with multi-ple extraction solvents.Methods: An optimized LC-MS method was generated for in-depth untargeted fin-gerprinting of chemical constituents in açaí extracts. Statistical analysis models wereused to describe relationships between the açaí extracts based on molecular featuresfound in both positive and negative mode ESI.Results: In an attempt to elucidate the differences in metabolites among açaí extractsfrom different cultivars, we identified or tentatively identified 173 metabolites fromthe 16 extracts made from 6 different sources. Of these compounds, there are138 reported in açaí for the first time. Statistical models showed similar yet distinctdifferences between the extracts tested based on the polarity of compounds presentand the origin of the source material.Conclusion: A high-resolution mass spectrometry method was generated thatallowed us to greatly characterize 16 complex extracts made from different sourcesof açaí with different extraction solvent polarities.

Keywords

açaí ; botanical dietary supplements ; chemical fingerprinting ; Euterpe oleracea Mart ; liquidchromatography ; mass spectrometry

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(±)-Catechin

A10029317295-85-498%

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56.0/1g

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(-)-Catechin

A42657418829-70-498%

(-)-Catechin

52.0/100mg

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(+)-Catechin

A499582154-23-497%

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17.0/50mg

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