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CAS No. :	1149705-71-4
Formula :	C₂₉H₃₇N₅O₃
M.W :	503.64
SMILES Code :	N(C(=O)C1=CC(N[C@@H](CC)C)=C(C(N)=O)C=C1C)[C@H]2C[C@@H]3N([C@H](C2)CC3)C4=CC=C(C(=O)C5CC5)C=N4
MDL No. :	MFCD22124888

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

RAF-inhibitor resistant cell lines	300 nM		Block ERK1/2 signaling	PMC4568562
ESTDAB037	200 nM	72 hours	Evaluate the effect of XL888 on the viability of ESTDAB037 cells, results showed that XL888 did not significantly reduce cell viability.	PMC5836539
A375 DR1	200 nM	72 hours	Evaluate the effect of XL888 on the viability of A375 DR1 cells, results showed that XL888 did not significantly reduce cell viability.	PMC5836539
MNT-1 DR100	200 nM	72 hours	Evaluate the effect of XL888 on the viability of MNT-1 DR100 cells, results showed that XL888 did not significantly reduce cell viability.	PMC5836539
M026R.X1.CL	200 nM	72 hours	Evaluate the effect of XL888 on the viability of M026R.X1.CL cells, results showed that XL888 did not significantly reduce cell viability.	PMC5836539
MNT-1	200 nM	72 hours	Evaluate the effect of XL888 on the viability of MNT-1 cells, results showed that XL888 did not significantly reduce cell viability.	PMC5836539
A375	200 nM	72 hours	Evaluate the effect of XL888 on the viability of A375 cells, results showed that XL888 did not significantly reduce cell viability.	PMC5836539
SK-Mel 28	200 nM	72 hours	Evaluate the effect of XL888 on the viability of SK-Mel 28 cells, results showed that XL888 did not significantly reduce cell viability.	PMC5836539
SK-Mel 24	200 nM	72 hours	Evaluate the effect of XL888 on the viability of SK-Mel 24 cells, results showed that XL888 significantly reduced cell viability.	PMC5836539
Human lung fibroblasts (IPF patients)	1 μM	5 days	XL888 preferentially targeted p16INK4a-hi fibroblasts, reducing their count	PMC11060735
Mouse lung fibroblasts	1 μM	3 days	Screening for compounds targeting p16Ink4a+ fibroblasts, XL888 significantly reduced GFP+ fibroblast count	PMC11060735
NRAS mutant melanoma cell lines (M245, M318, WM1361A, WM1366)	300 nM	24-72 hours	XL888 treatment led to the degradation of ARAF, CRAF, Wee1, Chk1, and cdc2, and was associated with decreased MAPK, AKT, mTOR, and JNK signaling. Apoptosis induction was associated with increased BIM expression and a decrease in the expression of the pro-survival protein Mcl-1.	PMC3683468
NRAS mutant melanoma cell lines (WM852, WM1346, WM1361A, WM1366, WMSbCl2, M202, M207, M244, M245, M318)	1nM – 30 µM	72 hours	XL888 inhibited the growth of NRAS mutant melanoma cells in a concentration-dependent manner and induced G2/M phase cell cycle arrest and apoptosis.	PMC3683468
NRAS mutant melanoma cell lines (M245, M318, WM1361A, WM1366)	300 nM	48 hours	XL888 treatment led to the degradation of ARAF, CRAF, Wee1, Chk1, and cdc2, and was associated with decreased MAPK, AKT, mTOR, and JNK signaling. Apoptosis induction was associated with increased BIM expression and a decrease in the expression of the pro-survival protein Mcl-1.	PMC4083119
HRAS Q61L-transduced NIH3T3 cells	300nM	72 hours	XL888 suppressed vemurafenib-driven MAPK signaling and decreased CRAF expression	PMC4567904
NRAS mutant melanoma cell lines	300nM	72 hours	XL888 suppressed vemurafenib-induced paradoxical MAPK activation and decreased CRAF expression	PMC4567904
NRAS mutant/wild-type BRAF cell lines	>100 nM		Reverse paradoxical activation of ERK1/2 induced by vemurafenib	PMC4568562

Mouse	Lung fibrosis model	Oral	62.5 mg/kg	5 days a week for 2 weeks	XL888 significantly reduced p16Ink4a+ fibroblast count in a murine model of lung fibrosis and attenuated fibrotic burden	PMC11060735
BALB SCID mice	NRAS mutant melanoma xenograft model (M245 cells)	Oral gavage	125 mg/kg	3 times per week for 18 days	XL888 treatment significantly slowed tumor growth (P=0.017) and induced tumor cell apoptosis (detected by TUNEL staining). In vivo studies showed that XL888 led to the degradation of CDK4 and Wee1 and inhibition of AKT/S6 signaling.	PMC3683468
SCID mice	NRAS mutant M245 melanoma xenograft model	Oral gavage	100 mg/kg	Three times per week for 15 days	Evaluate the anti-tumor efficacy of XL888 in vivo. Results showed XL888 significantly reduced tumor volume and increased HSP70 expression.	PMC4083119
C57BL/6 mice	Subcutaneous Panc02 tumor model	Oral	62.5mg/kg	3 times per week for 2 weeks	Combination therapy with XL888 and anti-PD-1 antibody significantly inhibited tumor growth and increased infiltration of CD8+ and CD4+ T cells	PMC7790996
Mice	SK-MEL-28 xenograft model	Oral	35mg, 45mg, 90mg, 135mg PO BIW	Twice weekly for 24 weeks	Reduce the number of hyperproliferative/neoplastic skin lesions	PMC4568562

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CAS No.: 1149705-71-4

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CAS No.: 1149705-71-4

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	1.99mL 0.40mL 0.20mL	9.93mL 1.99mL 0.99mL	19.86mL 3.97mL 1.99mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed