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Chemical Structure| 1035555-63-5 Chemical Structure| 1035555-63-5

Structure of TAK-733
CAS No.: 1035555-63-5

Chemical Structure| 1035555-63-5

TAK-733

CAS No.: 1035555-63-5

TAK-733 is a potent and selectiveMEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc.

4.5 *For Research Use Only !

Cat. No.: A118745 Purity: 98%

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Product Details of TAK-733

CAS No. :1035555-63-5
Formula : C17H15F2IN4O4
M.W : 504.23
SMILES Code : O=C1C(C(NC2=CC=C(I)C=C2F)=C(F)C(N3C)=O)=C3N=CN1C[C@@H](O)CO
MDL No. :MFCD24386349
InChI Key :RCLQNICOARASSR-SECBINFHSA-N
Pubchem ID :24963252

Safety of TAK-733

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of TAK-733

MAPK

Isoform Comparison

Biological Activity

Target
  • MEK1

    MEK1, IC50:3.2 nM

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Athymic nude mice PDTX models Oral gavage 10 mg/kg or 25 mg/kg once daily for a study duration To evaluate dosing efficacy and antitumor activity. PMC4671492

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00948467 Advanced Non-hematologic Malig... More >>nancies|Advanced Metastatic Melanoma Less << PHASE1 COMPLETED 2025-06-13 Wayne State University Karmano... More >>s Cancer Institute, Detriot, Michigan, 48201, United States|Roswell Park Cancer Institute, Buffalo, New York, 14263, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.98mL

0.40mL

0.20mL

9.92mL

1.98mL

0.99mL

19.83mL

3.97mL

1.98mL

References

 

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