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CAS No. :	307543-71-1
Formula :	C₁₅H₁₁NO₃S₂
M.W :	317.38
SMILES Code :	O=S(C1=CC=CS1)(/N=C/C2=C3C=CC=CC3=CC=C2O)=O
Synonyms :	IRE1 Inhibitor I
MDL No. :	MFCD02332975

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

Panc02.03	25 µM	72 h	STF-083010 inhibited XBP1 splicing activity, leading to increased lysosomes and reduced viability in PDAC cells	PMC6038181
primary neurons	50 μM	3 hours	STF-083010 inhibited OGD-induced IRE1 phosphorylation and suppressed inflaμMasome signaling and pyroptosis	PMC6412161
grass carp adipocytes	30 µM	48 hours	To explore the role of the IRE1α-XBP1 signaling axis in DHA-induced adipocyte lipolysis. The results showed that STF significantly reduced the expression of IRE1α and XBP1s genes induced by DHA, and attenuated the upregulation of lipolysis-related genes (ATGL, HSLa, and HSLb) and PKA signaling pathway-related genes (GNAS, ADCY5, PRKACAb, and PRKACBa) by DHA. Additionally, STF significantly reversed the reduction of cell TG content by DHA and diminished the enhanced activity of ATGL and HSL enzymes by DHA.	PMC10131065
P19 cells	5 µM	4 days	To screen for small molecules that induce neuronal differentiation in P19 cells	PMC164638
D3 cells	400 nM		To induce neuronal differentiation in D3 cells	PMC164638
CD4+ T cells	100 nM	14 days	Induction of phenotypic T SCM cells, demonstrating the generation of T SCM cells	PMC4776068
CD8+ T cells	100 nM	14 days	Induction of phenotypic T SCM cells, demonstrating the generation of T SCM cells	PMC4776068
Peripheral Blood Lymphocytes (PBLs)	1 × 10^7 PBLs	7 days	Generate allogeneic antigen-specific CD8+ T SCM cells and expand in vitro	PMC6286512
Primary microglia	10 μM	24 hours	To investigate the modulating effect of TWS119 on microglial polarization and its underlying mechanism, results showed that TWS119 promoted the switch of microglial polarization from pro-inflaμMatory to anti-inflaμMatory phenotype via the Wnt/β-catenin signaling pathway.	PMC6896312
Mouse brain microvascular endothelial cell line bEnd.3	10 μM	12 hours	To evaluate the effect of TWS119 on angiogenesis in OGD-injured bEnd.3 cells, results showed that TWS119 indirectly promoted angiogenesis by modulating microglial polarization and improving the inflaμMatory microenvironment.	PMC6896312
Neonatal rat cardiomyocytes (NRCMs)	1 μM	24 hours	To detect SNO-Hsp90 levels, it was found that SNO-Hsp90 levels were significantly increased after Ang II treatment.	PMC9343375
Neonatal rat cardiomyocytes (NRCMs)	50 μM	24 hours	To detect SNO-Hsp90 levels, it was found that SNO-Hsp90 levels were significantly increased after PE treatment.	PMC9343375
Human neurons	500 nM, 1 µM, 10 µM	80 minutes	To test the effect of GSK3 β inhibitor TWS119 on mitochondrial function, results showed that TWS119 at 1 µM and 10 µM increased the proportion of NADH, indicating increased mitochondrial respiration	PMC11485302

Rat	Neonatal hypoxic-ischemic brain injury model	Intranasal administration	7.48 µg/egg	Single dose, 5 days	To evaluate the short-term and long-term effects of STF-083010 on neonatal hypoxic-ischemic brain injury in rats. The results showed that STF-083010 significantly reduced brain infarct volume, improved neurological behavior, and attenuated brain atrophy.	PMC5797348
rats	spinal cord injury model	intraperitoneal injection	75μg/kg body weight	8 injections per day, 3-times a week for 4-weeks	STF-083010 inhibited SCI-induced IRE1 phosphorylation and alleviated inflammasome signaling and pyroptosis	PMC6412161
mice	APAP-induced liver injury model	intraperitoneal injection	15 μg/pup and 45 μg/pup	Single or multiple doses, lasting 2 days	Investigate the protective effect of STF-083010 on APAP-induced liver injury, found that STF significantly mitigated APAP-induced liver injury and inflammation	PMC8831621
Mice	High-fat diet-induced diabetes model	Intraperitoneal injection	10 mg/kg/d	once daily until the end of the experiment	STF-083010 inhibited IRE1α RNase activity, improved β-cell function, reduced inflammation, and reversed metabolic disorders.	PMC11094198
mice	NSG mice	tail vein injection	75 mg/kg	Single dose, sacrificed 24 hours later	Assess the long-term survival and repopulation capacity of T SCM cells, showing that T SCM cells persist long-term in vivo and can repopulate the effector pools	PMC4776068
NOD/SCID mice	LCL burden mouse model	Intravenous injection	30 mg/kg	Twice a week for two weeks	Evaluate the persistence and target cell eradication capacity of T SCM cells in vivo	PMC6286512
C57BL/6 mice	Permanent distal middle cerebral artery occlusion plus 1 h hypoxia model	Intraperitoneal injection	200,000 cells	single injection, lasting 10 weeks	To investigate the effect of TWS119 on neurological recovery following experimental stroke, results showed that TWS119 ameliorated the neuroinflammatory microenvironment by modulating microglial polarization toward the anti-inflammatory phenotype, thereby facilitating neurological recovery.	PMC6896312
C57BL/6J mice	Transverse aortic constriction (TAC) surgery model	Tail vein injection	1 × 10^7 T SCM cells	Single injection, observed for 35 days	To induce cardiac hypertrophy through TAC surgery, SNO-Hsp90 levels were detected, and it was found that SNO-Hsp90 levels were significantly increased after TAC surgery, and dramatically decreased in AAV9-GSNOR-treated mice.	PMC9343375
Mice	APPSAA/+ mice	Topical application	10 mg/kg	Once daily for 14 days	To test the effect of TWS119 on mitochondrial activity in APPSAA/+ mice, results showed that TWS119 increased mitochondrial activity	PMC11485302

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CAS No.: 307543-71-1

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CAS No.: 307543-71-1

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Precautionary Statements-General

Prevention

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	3.15mL 0.63mL 0.32mL	15.75mL 3.15mL 1.58mL	31.51mL 6.30mL 3.15mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed