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Chemical Structure| 2429877-44-9 Chemical Structure| 2429877-44-9

Structure of SD-36
CAS No.: 2429877-44-9

Chemical Structure| 2429877-44-9

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SD-36 is a PROTAC Degrader of STAT3 Protein. SD-36 potently induces the degradation of STAT3 protein in vitro and in vivo and demonstrates high selectivity over other STAT members. Induced degradation of STAT3 results in a strong suppression of its transcription network in leukemia and lymphoma cells. SD-36 inhibits the growth of a subset of acute myeloid leukemia and anaplastic large-cell lymphoma cell lines by inducing cell-cycle arrest and/or apoptosis. SD-36 achieves complete and long-lasting tumor regression in multiple xenograft mouse models at well-tolerated dose schedules.

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Product Details of SD-36

CAS No. :2429877-44-9
Formula : C59H62F2N9O12P
M.W : 1158.15
SMILES Code : C(N[C@H](C(NC(C1=CC=CC=C1)C2=CC=CC=C2)=O)CCC(N)=O)(=O)[C@H]3N4[C@](CC3)(CCN(C(CCCCCC#CC5=C6C(C(=O)N(C6)C7C(=O)NC(=O)CC7)=CC=C5)=O)C[C@H](NC(=O)C8=CC=9C(N8)=CC=C(C(P(=O)(O)O)(F)F)C9)C4=O)[H]
MDL No. :N/A

Safety of SD-36

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H318-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P310-P332+P313-P362-P403+P233-P405-P501
Class:9
UN#:3077
Packing Group:

Related Pathways of SD-36

JAK-STAT

Isoform Comparison

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0.86mL

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0.09mL

4.32mL

0.86mL

0.43mL

8.63mL

1.73mL

0.86mL

 

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