Structure of Rociletinib
CAS No.: 1374640-70-6
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets mutant forms of EGFR, including T790M, with Ki values of 21.5 nM for EGFRL858R/T790M and 303.3 nM for EGFRWT.
4.5
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CAS No. : | 1374640-70-6 |
Formula : | C27H28F3N7O3 |
M.W : | 555.55 |
SMILES Code : | C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O |
MDL No. : | MFCD26793864 |
InChI Key : | HUFOZJXAKZVRNJ-UHFFFAOYSA-N |
Pubchem ID : | 57335384 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Description |
Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively[1].
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Target |
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Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02147990 | Non-small Cell Lung Cancer | PHASE2 | TERMINATED | 2019-08-27 | UCLA Medical Center, Alhambra,... More >> California, 91801, United States|Comprehensive Blood and Cancer Center, Bakersfield, California, 93309, United States|Saint Jude Heritage Healthcare, Fullerton, California, 92835, United States|University of California San Diego Moores Cancer Center, La Jolla, California, 92093, United States|Northridge Hospital Medical Center, Northridge, California, 91328, United States|Cancer Care Associates, Redondo Beach, California, 90277, United States|University of California Davis Medical Center, Sacramento, California, 95817, United States|University of California San Francisco, San Francisco, California, 94115, United States|Coastal Integrative Cancer Care, San Luis Obispo, California, 93401, United States|Saint Mary's Regional Cancer Center, Grand Junction, Colorado, 81501-6132, United States|Rocky Mountain Cancer Centers, LLP, Lone Tree, Colorado, 80218, United States|Yale University School of Medicine, New Haven, Connecticut, 32135, United States|Advanced Medical Specialties, Miami, Florida, 33176, United States|Cleveland Clinic Florida, Weston, Florida, 33331, United States|Northwestern University Feinberg School of Medicine, Chicago, Illinois, 60611, United States|University of Illinois Chicago, Chicago, Illinois, 60612, United States|Illinois Cancer Specialists, Niles, Illinois, 60714, United States|Beth Israel Comprehensive Cancer Center, Boston, Massachusetts, 02215, United States|Lahey Hospital and Medical Center, Burlington, Massachusetts, 01805, United States|Minnesota Oncology Hematology, P.A, Minneapolis, Minnesota, 55404, United States|Mayo Clinic - Rochester, Rochester, Minnesota, 55905, United States|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States|Montefiore Medical Center, Bronx, New York, 10461, United States|New York Oncology Hematology, PC, Latham, New York, 12110-2188, United States|University of Rochester, Rochester, New York, 14642, United States|University Hospitals of Cleveland, Cleveland, Ohio, 44106, United States|Cleveland Clinic, Cleveland, Ohio, 44195, United States|Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States|Tennessee Oncology, PLLC, Nashville, Tennessee, 37203, United States|Texas Oncology P.A., Amarillo, Texas, 79106, United States|USO - Texas Oncology P.A., Arlington, Texas, 76014, United States|Texas Oncology-Austin Central, Austin, Texas, 78705, United States|Texas Oncology-Beaumont, Beaumont, Texas, 77702, United States|Texas Oncology P.A., Bedford, Texas, 76022, United States|Texas Oncology P.A., Dallas, Texas, 75246, United States|Texas Oncology P.A., Flower Mound, Texas, 75028, United States|The Methodist Hospital, Houston, Texas, 77030, United States|Texas Oncology - Plano East, Plano, Texas, 75075-7787, United States|Virginia Cancer Specialists, Fairfax, Virginia, 22031, United States|Northwest Cancer Specialists, P.C., Vancouver, Washington, 98686, United States|Yakima Valley Memorial Hospital, North Star Lodge, Yakima, Washington, 98902, United States|Icon Cancer Centre, South Brisbane, New South Wales, 4101, Australia|Royal North Shore Hospital, Sydney, New South Wales, 2065, Australia|Westmead Hospital, Westmead, New South Wales, 2145, Australia|Flinders Medical Centre, Bedford Park, South Australia, 5042, Australia|Princess Margaret Hospital, Toronto, Ontario, M5G 2L7, Canada|Centre Hospitalier Regional Universitaire (CHRU) de Besancon - L'Hopital Jean Minjoz, Besan?on, Franche-comte, 25030 cedex, France|H?pital Tenon, Paris, Ile-de-france, 75020, France|Institut Gustave Roussy, Villejuif, Ile-de-France, 94805, France|Institut de Cancérologie de l'Ouest - René Gauducheau, Saint Herblain cedex, PAYS DE LA Loire, France|Centre Hospitalier Lyon Sud, Pierre Bénité cedex, Rhone-alpes, 69495, France|Centre Hospitalier Universitaire C?te de Nacre, Caen, France|Centre Hospitalier Universitaire H?pital Nord, Marseille Cedex 20, 13915, France|Asklepios Fachkliniken München-Gauting, Gauting, Bayern, 82131, Germany|Klinikum Innenstadt LMU, München, Bayern, 80336, Germany|Goethe-Universit?t Frankfurt am Main, Frankfurt am Main, Hessen, 60590, Germany|Pius Hospital Oldenburg, Oldenburg, Niedersachsen, 26121, Germany|Universitaetsklinikum Bonn - Zentrum fuer Innere Medizin - Medizinische Klinik und Poliklink III, Bonn, Nordrhein-westfalen, 53127, Germany|Universit?tsklinikum Essen, Essen, Nordrhein-westfalen, 45122, Germany|Universit?tsklinikum K?ln, K?ln, Nordrhein-westfalen, 50937, Germany|LungenClinic Gro?hansdorf GmbH, Gro?hansdorf, Schleswig-holstein, 22927, Germany|Evangelische Lungenklinik Berlin, Berlin, 13125, Germany|Queen Mary Hospital, Hong Kong, Hong Kong|Chungbuk National University Hospital, Chungju, Chungcheongbuk-do, Korea, Republic of|National Cancer Center, Goyang-si, Gyeonggi-do, Korea, Republic of|Gachon University Gil Medical Center, Incheon, Gyeonggi-do, 405-760, Korea, Republic of|Dong-A University Hospital, Busan, Korea, Republic of|Inha University Hospital, Incheon, 400-711, Korea, Republic of|Samsung Medical Center, Seoul, 135-710, Korea, Republic of|Asan Medical Center, Seoul, Korea, Republic of|Seoul National University Hospital, Seoul, Korea, Republic of|Seoul Saint Mary's Hospital, Seoul, Korea, Republic of|Severance Hospital, Yonsei University Health System, Seoul, Korea, Republic of|Antoni van Leeuwenhoek Hospital, Amsterdam, Noord-holland, 1066 CX, Netherlands|Vrije Universiteit Medisch Centrum, Amsterdam, 1081 HV, Netherlands|Hospital Universitario Virgen del Rocio, Seville, Sevilla, 41013, Spain|Hospital Universitari Germans Trias i Pujol, Badalona, Spain|Hospital Vall d′Hebrón, Barcelona, 08035, Spain|Hospital Universitario Quirón Dexeus, Barcelona, Spain|Hospital Universitario La Paz, Madrid, Spain|Centre Hospitalier Universitaire Vaudoise, Lausanne, Vaud, 1011, Switzerland|Taipei Veterans General Hospital, Taipei, Taipei CITY, 11217, Taiwan|Chang Gung Memorial Hospital Linkou, Taoyuan, Tao-Yuan, 33305, Taiwan|China Medical University Hospital, Taichung, 40447, Taiwan|Taichung Veterans General Hospital, Taichung, 40705, Taiwan|National Taiwan University Hospital, Taipei, 100, Taiwan|Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, CB2 0QQ, United Kingdom|Guy's and Saint Thomas NHS Foundation Trust, London, Greater London, SE1 9RT, United Kingdom|Royal Marsden Hospital, London, Greater London, SW3 6JJ, United Kingdom|Royal Marsden NHS Trust, Sutton, Surrey, SM2 5PT, United Kingdom|University College Hospital, London, NW1 2PQ, United Kingdom Less << |
NCT02547675 | Non-small Cell Lung Cancer | NO_LONGER_AVAILABLE | - | Mayo Clinic Arizona, Scottsdal... More >>e, Arizona, 85024, United States|Compassionate Care Research Group, Inc., Fountain Valley, California, 92866, United States|Pacific Cancer Care, Monterey, California, 93940, United States|Sutter Cancer Institute, Sacramento, California, 95816, United States|UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, 94115, United States|Halifax Health - Center for Oncology, Daytona Beach, Florida, 32114, United States|UF Health Center Orlando, Orlando, Florida, 32806, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States|Henry Ford Hospital, Detroit, Michigan, 48202, United States|Billings Clinic, Billings, Montana, 59101, United States|Tulsa Cancer Institute, Tulsa, Oklahoma, 74146, United States Less << |
Tags: Rociletinib | CO-1686 | AVL-301 | CNX-419 | CO1686 | CO 1686 | AVL301 | AVL 301 | AVL-301 | CNX419 | CNX 419 | CNX-419 | EGFR | Epidermal growth factor receptor | ErbB-1 | HER1 | 1374640-70-6
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H316 | Causes mild skin irritation |
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H319 | Causes serious eye irritation |
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H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
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H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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