Structure of Rabeprazole
CAS No.: 117976-89-3
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Rabeprazole, an antiulcer drug, can irreversibly inhibit gastric H+/K+ ATPase pump with IC50 of 72 nM.
Synonyms: LY307640
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 117976-89-3 |
Formula : | C18H21N3O3S |
M.W : | 359.44 |
SMILES Code : | COCCCOC1=C(C)C(CS(=O)C2=NC3=C(N2)C=CC=C3)=NC=C1 |
Synonyms : |
LY307640
|
MDL No. : | MFCD00868879 |
InChI Key : | YREYEVIYCVEVJK-UHFFFAOYSA-N |
Pubchem ID : | 5029 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
Human lung microvascular endothelial cells (HLMVECs) | 20 μM | 18 hours | Rabeprazole induced HIF1A mRNA expression in a dose-dependent manner | PMC9105578 |
Dematiaceous fungi | 2-128 mg/ml | 72h | Rabeprazole alone exhibited limited antifungal effect against all tested species. However, the median MICs of azoles and RAB in the combination revealed up to 7.7-fold and 128-fold reduction compared to that when tested alone, respectively. | PMC10831725 |
Candida spp. | 2-128 mg/ml | 24h | Rabeprazole alone exhibited limited antifungal effect against all tested species. However, the median MICs of azoles and RAB in the combination revealed up to 7.7-fold and 128-fold reduction compared to that when tested alone, respectively. | PMC10831725 |
Aspergillus fumigatus | 2-128 mg/ml | 48h | Rabeprazole alone exhibited limited antifungal effect against all tested species. However, the median MICs of azoles and RAB in the combination revealed up to 7.7-fold and 128-fold reduction compared to that when tested alone, respectively. | PMC10831725 |
Trypanosoma cruzi epimastigotes | 1 mM | 4 hours | To evaluate the effect of Rabeprazole on cell viability and TIM enzyme activity with different numbers of parasites in a short time. Results showed that Rabeprazole significantly reduced cell viability and TIM enzyme activity. | PMC10351538 |
Trypanosoma cruzi epimastigotes | 250 μM | 24 hours | To evaluate the effect of Rabeprazole on cell viability and TIM enzyme activity with different numbers of parasites in a short time. Results showed that Rabeprazole significantly reduced cell viability and TIM enzyme activity. | PMC10351538 |
Trypanosoma cruzi epimastigotes | 100–2000 μM | 4 hours | To evaluate the effect of Rabeprazole on cell viability and TIM enzyme activity with different numbers of parasites in a short time. Results showed that Rabeprazole significantly reduced cell viability and TIM enzyme activity. | PMC10351538 |
Human lung microvascular endothelial cells (HLMVECs) | 20 μM | 18 hours | Rabeprazole induced HIF1A mRNA expression in a dose-dependent manner | PMC9105578 |
HEK293 cells | 100 μM | 48 hours | Evaluate the effect of SR9009 on a luciferase reporter driven by the Bmal1 promoter | PMC11578692 |
AGS cells | 100 μM | 48 hours | To study the effect of NAM on LONP1 expression. Results showed that NAM treatment increased the expression and acetylation level of LONP1. | PMC11578692 |
BGC823 cells | 100 μM | 48 hours | Rabeprazole inhibited CREB phosphorylation and nuclear translocation, reducing the binding of CREB to the GPX4 promoter, thereby decreasing GPX4 expression and inducing ferroptosis. | PMC11578692 |
Campylobacter jejuni and C. coli | 16 µg/ml | immediately | RPZ-TH and PPIs also inhibited the motility of C. jejuni and C. coli, but had no effect on other bacteria such as V. cholerae and S. enterica. | PMC101604 |
Helicobacter pylori | 16 µg/ml | immediately | Rabeprazole (RPZ) and its thioether derivative (RPZ-TH) markedly inhibited the motility of H. pylori. RPZ-TH completely blocked motility at 1 µg/ml, while RPZ had an IC50 of 16 µg/ml. | PMC101604 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
B10.RIII mice | Experimental autoimmune uveitis (EAU) model | Intraperitoneal injection | 60 mg/kg/day | Once daily for 7 days (from Day 7 to Day 14) | To evaluate the effect of rabeprazole on the EAU mouse model. Results showed that rabeprazole reduced anterior chamber inflammation and retinal inflammation, inhibited TNF and IL-1β expression, and promoted IL-10 expression. | PMC9253297 |
C57BL/6 mice | DNBS and DSS-induced colitis models | Oral | 30 mg/kg | Twice daily, throughout the experiment | Rabeprazole failed to demonstrate any anti-colitic effect | PMC9174989 |
Mice | Endotoxemia-induced inflammatory lung injury model | Oral | 18 mg/kg | Administered at 4 and 20 hours post-LPS | Rabeprazole promotes vascular repair and resolution of inflammatory lung injury through HIF-1α/FoxM1 signaling | PMC9105578 |
Wistar rats | Anesthetized rat model | Intravenous injection | 4 mg/kg | Single dose, lasting 2 hours | To investigate the effects of Rabeprazole on the concentration of amoxicillin in gastric juice and gastric mucosa. Results showed that Rabeprazole increased the amoxicillin concentration in gastric juice but did not significantly alter its concentration in blood or gastric mucosa. | PMC4007658 |
Mice | Endotoxemia-induced inflammatory lung injury model | Oral | 18 mg/kg | Administered at 4 and 20 hours post-LPS | Rabeprazole promoted vascular repair and resolution of inflammatory lung injury through HIF-1α/FoxM1 signaling | PMC9105578 |
Female Swiss albino mice | Osteoporosis model | Oral | 10 mg/kg every 48 hours | Every 48 hours for 18 weeks | To investigate the impact of rabeprazole on osteoporosis and explore the modulatory effects of dietary calcium or alendronate on this side effect. Results showed that rabeprazole significantly reduced bone mineral density, increased trabecular separation and osteoclast number. Calcium supplementation or alendronate partially restored bone density and reduced osteoclast activity. | PMC7237708 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT01408186 | Upper Gastrointestinal Bleedin... More >>g Less << | Phase 3 | Completed | - | Hong Kong ... More >> Prince of Wales Hospital Hong Kong, Hong Kong Japan Second Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan Izumo, Japan Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan Kyoto, Japan Department of Gastroenterology, Osaka City General Hospital, Osaka, Japan (Satellite hospital of Osaka City University) Osaka, Japan Department of Gastroenterology, Osaka City University Graduate School of Medicine Osaka, Japan Department of Gastroenterology, Takarazuka Municipal Hospital, Hyogo, Japan (Satellite hospital of Osaka City University) Osaka, Japan Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan Osaka, Japan Department of Internal Medicine and Gastroenterology, Saga Medical School, Saga, Japan Saga, Japan Less << |
NCT03658733 | Helicobacter Pylori Infection | Phase 4 | Not yet recruiting | October 31, 2019 | China, Shandong ... More >> Xiuli Zuo Recruiting Jinan, Shandong, China Contact: Xiuli Zuo, PhD,MD 15588818685 ext 053188369277 zuoxiuli@sina.com Sub-Investigator: Yue Li, MD Sub-Investigator: Chaoran Ji, MD Less << |
NCT01918176 | Healthy | Phase 1 | Completed | - | United States, Florida ... More >> Pfizer Investigational Site South Miami, Florida, United States, 33143 Less << |
NCT00165672 | - | Completed | - | - | |
NCT03726099 | Helicobacter Pylori Infection | Phase 4 | Not yet recruiting | March 30, 2020 | China, Shandong ... More >> Xiuli Zuo Jinan, Shandong, China Less << |
NCT01237353 | Pharmacodynamic | Not Applicable | Completed | - | United States, California ... More >> University of California San Francisco San Francisco, California, United States, 94143 Less << |
NCT00165672 | Non-erosive Gastroesophageal R... More >>eflux Disease Less << | Phase 3 | Completed | - | Japan ... More >> Nagoya, Aichi-Prefecture, Japan, 467-0001 Fukuoka, Fukuoka-Prefecture, Japan, 810-0001 Fukuoka, Fukuoka-Prefecture, Japan, 811-0213 Yukuhashi, Fukuoka-Prefecture, Japan, 824-0026 Hiroshima, Hiroshima-Prefecture, Japan, 734-0037 Osaka, Osaka-Prefecture, Japan, 530-0012 Osaka, Osaka-Prefecture, Japan, 545-0051 Saga, Saga-Prefecture, Japan, 849-0937 Otsu, Shiga-Prefecture, Japan, 520-2121 Izumo, Shimane-Prefecture, Japan, 693-0021 Bunkyo-ku, Tokyo, Japan, 113-0022 Shinjuku-ku, Tokyo, Japan, 162-0052 Ube, Yamaguchi-Prefecture, Japan, 755-0046 Less << |
NCT01237353 | - | Completed | - | - | |
NCT00234117 | Bronchial Asthma|Gastroesophag... More >>eal Reflux Less << | COMPLETED | - | Ponce Gastroentrology Research... More >>, Ponce, 00717, Puerto Rico Less << | |
NCT01772290 | Healthy Volunteer | Phase 1 | Completed | - | United States, Florida ... More >> Daytona Beach, Florida, United States, 32117 United States, Texas Dallas, Texas, United States, 75247 Less << |
NCT01249651 | - | Completed | - | - | |
NCT03530995 | Drug Drug Interaction ... More >> Autoimmune Diseases Fibrotic Disease Less << | Phase 1 | Recruiting | June 15, 2019 | United Kingdom ... More >> Quotient Sciences Ltd Recruiting Ruddington, Nottingham, United Kingdom, NG11 6JS Contact: Nand Singh, MD Less << |
NCT01249651 | Heartburn | Phase 4 | Completed | - | China ... More >> Research Site Bejing, China Less << |
NCT00747695 | GERD | Phase 1 | Completed | - | - |
NCT01264822 | - | Completed | - | Japan ... More >> Nagoya, Aichi, Japan Hirosaki, Aomori, Japan Kashiwa, Chiba, Japan Matsuyama, Ehime, Japan Fukuyama, Hiroshima, Japan Sapporo, Hokkaido, Japan Amagasaki-shi, Hyogo, Japan Kobe, Hyogo, Japan Hitachi, Ibaraki, Japan Takamatsu, Kagawa, Japan Isehara, Kanagawa, Japan Sendai, Miyagi, Japan Nagano-shi, Nagano, Japan Suzaka, Nagano, Japan Oita-shi, Oita, Japan Yufu, Oita, Japan Kurashiki, Okayama, Japan Tsuyama, Okayama, Japan Hirakata, Osaka, Japan Osakasayama, Osaka, Japan Takatsuki, Osaka, Japan Matsue, Shimane, Japan Hamamatsu, Shizuoka, Japan Otawara-shi, Tochigi, Japan Chuo, Tokyo, Japan Itabashi, Tokyo, Japan Minato-ku, Tokyo, Japan Shinagawa-ku, Tokyo, Japan Yamagata-shi, Yamagata, Japan Ube, Yamaguchi, Japan Fukuoka, Japan Hiroshima, Japan Kyoto, Japan Nagasaki, Japan Nara, Japan Niigata, Japan Okayama, Japan Osaka, Japan Saga, Japan Tottori, Japan Toyama, Japan Yamaguchi, Japan Less << | |
NCT00287391 | Insomnia|GERD | PHASE4 | COMPLETED | 2025-12-06 | UNC Gastroenterology and UNC S... More >>leep Disorders Center, Chapel Hill, North Carolina, 27599, United States Less << |
NCT00539240 | Gastroesophageal Reflux Diseas... More >>e Less << | Phase 2 Phase 3 | Completed | - | United States, Arizona ... More >> Southern Arizona VA Health Care System, Tucson Tucson, Arizona, United States, 85723 Less << |
NCT00354757 | GERD | Phase 4 | Completed | - | Taiwan ... More >> National Taiwan Univeristy Hospital Taipei, Taiwan, 100 Less << |
NCT00539240 | - | Completed | - | - | |
NCT01397084 | Gastroesophageal Reflux Diseas... More >>e GERD Reflux Esophagitis Less << | Phase 4 | Completed | - | - |
NCT01397084 | - | Completed | - | - | |
NCT02463643 | Esophagitis, Reflux | Phase 2 | Completed | - | Japan ... More >> Tokyo, Japan Less << |
NCT02509923 | Healthy | Phase 1 | Completed | - | Japan ... More >> Tokyo, Japan Less << |
NCT01153659 | Healthy | Phase 1 | Completed | - | United States, Oklahoma ... More >> Oklahoma Foundation for Digestive Research Oklahoma City, Oklahoma, United States, 73104 Less << |
NCT02311946 | Healthy | Phase 1 | Completed | - | United States, Florida ... More >> MRA Clinical Research - Phase 1 Miami, Florida, United States, 33143 Miami Research Associates, LLC South Miami, Florida, United States, 33143 MRA Clinical Research, LLC South Miami, Florida, United States, 33143 Less << |
NCT02847455 | Duodenal Ulcer | Phase 2 Phase 3 | Completed | - | - |
NCT00681005 | GERD | Not Applicable | Completed | - | - |
NCT01287091 | Healthy Volunteer | Phase 1 | Completed | - | United States, Texas ... More >> Investigational Site Austin, Texas, United States, 78744 Less << |
NCT00214552 | Asthma Gastro... More >>esophageal Reflux Disease Less << | Phase 3 | Completed | - | United States, Washington ... More >> ASTHMA, Inc. Richland, Washington, United States, 99352 ASTHMA, Inc. Seattle, Washington, United States, 98105 Less << |
NCT00125736 | Stomach Ulcer | Phase 4 | Completed | - | Japan ... More >> Kariya, Aichi, Japan Nagoya, Aichi, Japan Seto, Aichi, Japan Toyoake, Aichi, Japan Toyohashi, Aichi, Japan Akita, Akira, Japan Urayasu, Chiba, Japan Niihama, Ehime, Japan Chikushino, Fukoka, Japan Kurume, Fukoka, Japan Oumuta, Fukoka, Japan Tagawa, Fukoka, Japan Sabae, Fukui, Japan Hashima, Gifu, Japan Asahikawa, Hokkaido, Japan Sapporo, Hokkaido, Japan Miki, Hyogo, Japan Kanazawa, Ishikawa, Japan Kumamotoi, Kumamoto, Japan Sendai, Miyagi-prefecture, Japan Kashihara, Nara, Japan Yufu, Oita, Japan Ikeda, Osaka, Japan Izumisano, Osaka, Japan Kadoma, Osaka, Japan Takatsuki, Osaka, Japan Hasuda, Saitama, Japan Kitaadachi-gun, Saitama, Japan Matue, Shimane, Japan Hamamatsu, Shizouka, Japan Minato-ku, Tokyo, Japan Shinagawa-ku, Tokyo, Japan Shinjyuku-ku, Tokyo, Japan Shimonoseki, Yamaguchi, Japan Fukoka, Japan Gifu, Japan Hiroshima, Japan Kouchi, Japan Kyoto, Japan Nara, Japan Nigata, Japan Oita, Japan Saga, Japan Less << |
NCT00304421 | Gastroesophageal Reflux Diseas... More >>e Less << | Phase 4 | Completed | - | United States, California ... More >> VA Greater Los Angeles Healthcare System Los Angeles, California, United States, 90073 Less << |
NCT01089543 | Functional Dyspepsia | Phase 2 | Completed | - | Japan ... More >> Nagoya, Aichi, Japan Chikushino, Fukuoka, Japan Kitakyushu, Fukuoka, Japan Maebashi, Gunma, Japan Sapporo, Hokkaido, Japan Kobe, Hyogo, Japan Nishinomiya, Hyogo, Japan Tsuchiura, Ibaraki, Japan Takamatsu, Kagawa, Japan Yokohama, Kanagawa, Japan Sendai, Miyagi, Japan Yufu, Oita, Japan Nakagami, Okinawa, Japan Hirakata, Osaka, Japan Moriguchi, Osaka, Japan Suita, Osaka, Japan Takatsuki, Osaka, Japan Karatsu, Saga, Japan Kusatsu, Shiga, Japan Izumo, Shimane, Japan Fujieda, Shizuoka, Japan Hamamatsu, Shizuoka, Japan Otawara, Tochigi, Japan Shimotsuga, Tochigi, Japan Bunkyo, Tokyo, Japan Mitaka, Tokyo, Japan Nakano, Tokyo, Japan Ota, Tokyo, Japan Setagaya, Tokyo, Japan Shibuya, Tokyo, Japan Shinagawa, Tokyo, Japan Akita, Japan Fukuoka, Japan Gifu, Japan Hiroshima, Japan Kagoshima, Japan Kochi, Japan Kumamoto, Japan Kyoto, Japan Miyazaki, Japan Oita, Japan Osaka, Japan Saga, Japan Saitama, Japan Shizuoka, Japan Yamagata, Japan Less << |
NCT01136317 | Gastroesophageal Reflux | Phase 2 | Completed | - | France ... More >> CHU de Nantes Nantes, France, 44093 Less << |
NCT03521726 | Helicobacter Pylori Infection | Phase 4 | Recruiting | October 26, 2019 | Taiwan ... More >> Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan Recruiting Taipei, Taiwan, 10449 Contact: Tai-cherng Liou, MD 886-2-25433535 ext 3990 mmhltc@gmail.com Less << |
NCT01513785 | Functional Dyspepsia | Phase 2 | Completed | - | China, Shanghai ... More >> GI Division, Shanghai Jiao-Tong University School of Medicine Renji Hospital Shanghai, Shanghai, China, 200001 Less << |
NCT01089543 | - | Completed | - | - | |
NCT00464308 | - | Completed | - | - | |
NCT00511745 | - | Terminated(Due to the achievem... More >>ent of minimum required sample size and new changes in local regulations.) Less << | - | - | |
NCT02037477 | - | Completed | - | - | |
NCT02037477 | Healthy Volunteers | Phase 3 | Completed | - | Japan ... More >> Fukuoka-shi, Fukuoka, Japan Less << |
NCT03220191 | Healthy Volunteer | Phase 1 | Completed | - | United States, Connecticut ... More >> Pfizer New Haven Clinical Research Unit New Haven, Connecticut, United States, 06511 Less << |
NCT00378287 | GERD | Phase 1 | Completed | - | - |
NCT02638584 | Gastric Cancer | Phase 4 | Unknown | October 2017 | Korea, Republic of ... More >> HALLYM UNIVERSITY MEDICAL CENTER, Chuncheon Sacred Heart Hospital Recruiting Chuncheon, Gangwon-do, Korea, Republic of Contact: ChangSeok Bang, MD,PhD cloudslove@hallym.or.kr Less << |
NCT00236392 | Gastroesophageal Reflux ... More >> Heartburn Less << | Phase 3 | Completed | - | - |
NCT00132496 | Gastroesophageal Reflux Diseas... More >>e Less << | Phase 2 | Completed | - | - |
NCT01990378 | Healthy | Phase 1 | Completed | - | India ... More >> AXIS Clinicals Limited Miyapur, Hyderabad, India, 500 050 Less << |
NCT00464308 | Gastro-oesophageal Reflux | Phase 4 | Completed | - | Australia ... More >> Belconnen, Australia Bondi Junction, Australia Brookvale, Australia Browns Plains, Australia Campbelltown, Australia Campsie, Australia Caringbah, Australia Castle Hill, Australia Charlestown, Australia Dapto, Australia Darlinghurst, Australia Dubbo, Australia Elizabeth, Australia Fairfield, Australia Hoppers Crossing, Australia Ingleburn, Australia Leichhardt, Australia Maroubra, Australia Melton, Australia Mount Druitt, Australia Oaklands Park, Australia Royal Park, Australia Sydney, Australia Wentworthville, Australia Wyoming, Australia Less << |
NCT01990586 | Healthy | Phase 1 | Completed | - | India ... More >> AXIS Clinicals Limited Miyapur, Hyderabad, India, 500 050 Less << |
NCT00237367 | Gastroesophageal Reflux | Phase 4 | Completed | - | - |
NCT00216450 | Helicobacter Infections ... More >> Bacterial Infections Less << | Phase 4 | Completed | - | - |
NCT00132496 | - | Completed | - | - | |
NCT00517114 | Gastroesophageal Reflux ... More >> Laryngitis Less << | Not Applicable | Completed | - | China ... More >> Queen Mary Hospital Hong Kong, China Less << |
NCT01566643 | Helicobacter Pylori Infection | Phase 4 | Unknown | December 2012 | Taiwan ... More >> Buddhist Tzu Chi General Hospital Recruiting Hualien, Taiwan, 97002 Contact: Ming-Cheh CHEN, MD +886-910-521003 MingCheh_chen@tzuchi.com.tw Principal Investigator: Ming-Cheh CHEN, MD Sub-Investigator: Chi-Tan HU, PhD, MD Sub-Investigator: Wei-Yi RAY, MD Less << |
NCT02423187 | - | Completed | - | Japan ... More >> Nagoya, Japan Osaka, Japan Tokyo, Japan Less << | |
NCT00216489 | Gastroesophageal Reflux ... More >> Heartburn Less << | Phase 4 | Completed | - | - |
NCT00648349 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Less << |
NCT02569554 | Healthy | Phase 1 | Completed | - | Belgium ... More >> Pfizer Clinical Research Unit Brussels, Belgium, B-1070 Less << |
NCT01954043 | Cancer | Phase 1 | Completed | - | United States, Arizona ... More >> GSK Investigational Site Goodyear, Arizona, United States, 85338 United States, Texas GSK Investigational Site Dallas, Texas, United States, 75201 United States, Washington GSK Investigational Site Tacoma, Washington, United States, 98405 Australia, Victoria GSK Investigational Site Heidelberg, Victoria, Australia, 3084 GSK Investigational Site Melbourne, Victoria, Australia, 3004 United Kingdom GSK Investigational Site London, United Kingdom, W1G 6AD Less << |
NCT00649493 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Less << |
NCT00649194 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Less << |
NCT01286194 | - | Completed | - | - | |
NCT01202071 | Healthy | Phase 2 | Completed | - | Japan ... More >> Toshima-ku, Tokyo, Japan Less << |
NCT00614536 | - | Completed | - | - | |
NCT01202071 | - | Completed | - | - | |
NCT00838526 | Gastroesophageal Reflux Diseas... More >>e (GERD) Less << | Phase 3 | Completed | - | United States, Illinois ... More >> Ltd. Moline, Illinois, United States, 61265 Midwest Clinical Moline, Illinois, United States, 61265 Research Associates Moline, Illinois, United States, 61265 Moline, Illinois, United States, 61265 Less << |
NCT00839306 | - | Completed | - | - | |
NCT01186497 | Healthy | Phase 1 | Completed | - | - |
NCT00220857 | Normal Subjects | PHASE4 | COMPLETED | 2025-09-07 | Temple University School of Me... More >>dicine, Philadelphia, Pennsylvania, 19140, United States Less << |
NCT02699710 | Healthy Volunteer | Phase 1 | Completed | - | United Kingdom ... More >> Quotient Clinical Ltd, Clinical Research Unit Nottingham, United Kingdom, NG11 6JS Less << |
NCT00839306 | Gastroesophageal Reflux Diseas... More >>e (GERD) Less << | Phase 3 | Completed | - | United States, Illinois ... More >> Associates, Ltd. Moline, Illinois, United States, 61265 Midwest Clinical Moline, Illinois, United States, 61265 Research Moline, Illinois, United States, 61265 Moline, Illinois, United States, 61265 Less << |
NCT00992589 | Gastroesophageal Reflux | Phase 3 | Completed | - | - |
NCT00992589 | - | Completed | - | - | |
NCT02477306 | Healthy | Phase 1 | Completed | - | Egypt ... More >> Genuine Research Center GRC Cairo, Egypt Less << |
NCT00838526 | - | Completed | - | - | |
NCT03037606 | Gastroesophageal Reflux Diseas... More >>e Less << | Phase 4 | Completed | - | Turkey ... More >> Ege University Facult of Medicine Gastroenterology Department Izmir, Turkey, 35100 Less << |
NCT02446483 | - | Completed | - | - | |
NCT01277718 | Healthy Volunteer | Phase 1 | Completed | - | - |
NCT03658473 | Gastric Lesion | Phase 3 | Completed | - | Brazil ... More >> Galeno Desenvolvimento de Pesquisas Clinicas Ltda. Campinas, SP, Brazil, 13087-010 Less << |
NCT01277718 | - | Completed | - | - | |
NCT00658528 | Gastroesophageal Reflux Diseas... More >>e (GERD) Less << | Phase 3 | Completed | - | - |
NCT00658775 | Gastroesophageal Reflux Diseas... More >>e (GERD) Less << | Phase 3 | Completed | - | - |
NCT00658775 | - | Completed | - | - | |
NCT01575899 | Helicobacter Pylori Infection | Phase 4 | Terminated(Early termination d... More >>ue to efficacy) Less << | - | Taiwan ... More >> Buddhist Tzu Chi General Hospital Hualien, Taiwan, 97002 Less << |
NCT00658632 | Gastroesophageal Reflux Diseas... More >>e (GERD) Less << | Phase 3 | Completed | - | - |
NCT00658632 | - | Completed | - | - | |
NCT01037491 | Gastric Ulcer ... More >> Duodenal Ulcer Less << | Not Applicable | Unknown | December 2010 | Taiwan ... More >> Taipei Veterans General Hospital Recruiting Taipei, Taiwan, 11217 Contact: Jiing-Chyuan Luo, M.D. 886-2-28712121 ext 3346 jcluo@vghtpe.gov.tw Principal Investigator: Jiing-Chyuan Luo, M.D. Less << |
NCT01241409 | Healthy | Phase 1 | Completed | - | - |
NCT01575899 | - | Terminated(Early termination d... More >>ue to efficacy) Less << | - | - | |
NCT01699113 | Hypergastrinaemia | Phase 1 | Completed | - | United Kingdom ... More >> Hammersmith Medicines Research London, United Kingdom Less << |
NCT00553449 | Gastroesophageal Reflux ... More >> Heartburn Less << | Phase 3 | Completed | - | - |
NCT00222170 | Esophageal Reflux | PHASE2 | COMPLETED | 2025-05-07 | University of Kansas Medical C... More >>enter, Kansas City, Kansas, 66160, United States Less << |
NCT02446483 | Gastrointestinal Diseases | Phase 4 | Completed | - | Egypt ... More >> GSK Investigational Site Cairo, Egypt Less << |
NCT02475161 | Healthy | Phase 1 | Completed | - | United States, Kansas ... More >> Overland Park, Kansas, United States Less << |
NCT00165841 | - | Completed | - | - | |
NCT00658528 | - | Completed | - | - | |
NCT00165841 | Gastroesophageal Reflux Diseas... More >>e Less << | Phase 2 | Completed | - | United States, California ... More >> Quality Care Medical Center Inc. Vista, California, United States, 92085 Less << |
NCT00747526 | Gastroesophageal Reflux Diseas... More >>e (GERD) Less << | Phase 1 | Completed | - | United States, Arkansas ... More >> Little Rock, Arkansas, United States United States, California Oakland, California, United States United States, District of Columbia Washington, District of Columbia, United States United States, Florida Maitland, Florida, United States United States, Kentucky Louisville, Kentucky, United States United States, Mississippi Jackson, Mississippi, United States United States, Missouri Bridgeton, Missouri, United States United States, New Jersey Long Branch, New Jersey, United States United States, North Carolina Greenville, North Carolina, United States United States, Ohio Cleveland, Ohio, United States Toledo, Ohio, United States Youngstown, Ohio, United States United States, Texas Houston, Texas, United States Belgium Antwerpen, Belgium Brussel, Belgium Brazil Sao Paulo, Brazil Poland Lublin, Poland Warszawa, Poland United Kingdom Barnsley N/A, United Kingdom London, United Kingdom Less << |
NCT00787891 | Gastroesophageal Reflux Diseas... More >>e (GERD) Less << | Phase 3 | Completed | - | - |
NCT00787891 | - | Completed | - | - | |
NCT01219764 | Helicobacter Infections | Phase 4 | Completed | - | Lebanon ... More >> American University of Beirut - Medical Center Beirut, Lebanon Less << |
NCT00989300 | Healthy | Phase 1 | Completed | - | - |
NCT00911534 | - | Completed | - | - | |
NCT00236197 | - | Completed | - | - | |
NCT03108287 | Helicobacter Pylori Infection | Phase 4 | Completed | - | - |
NCT01008696 | Reflux Esophagitis | Phase 4 | Completed | - | - |
NCT00236184 | Heartburn | Phase 3 | Completed | - | United States, California ... More >> Jeffrey L. Newman Vista, California, United States, 92084 Less << |
NCT00911534 | Symptomatic Gastroesophageal R... More >>eflux Disease (sGERD) Less << | Phase 3 | Completed | - | - |
NCT01008696 | - | Completed | - | - | |
NCT00236197 | Heartburn | Phase 3 | Completed | - | United States, New York ... More >> New York Center For Clinical Research Lake Success, New York, United States, 11042 Less << |
NCT00855361 | Gastroesophageal Reflux | Phase 1 | Completed | - | United States, California ... More >> Orange, California, United States United States, District of Columbia Washington, District of Columbia, United States United States, Georgia Augusta, Georgia, United States United States, Illinois Maywood, Illinois, United States United States, Kentucky Louisville, Kentucky, United States United States, Louisiana Shreveport, Louisiana, United States United States, Michigan Lansing, Michigan, United States United States, Nebraska Omaha, Nebraska, United States United States, New York Brooklyn, New York, United States United States, Ohio Toledo, Ohio, United States Germany Aachen, Germany Poland Bydgoszcz, Poland Lublin Poland, Poland Odz, Poland Poznan N/A, Poland United Kingdom Barnsley N/A, United Kingdom Manchester, United Kingdom Preston, United Kingdom Sheffield, United Kingdom Less << |
NCT01101646 | Gastroesophageal Reflux | Phase 1 | Completed | - | United States, Kansas ... More >> Overland Park, Kansas, United States Less << |
NCT01321567 | - | Completed | - | - | |
NCT01398410 | - | Completed | - | - | |
NCT03290703 | Healthy Volunteers | Phase 1 | Completed | - | United Kingdom ... More >> Quotient Clinical Ltd, Clinical Research Unit Nottingham, United Kingdom, NG11 6JS Less << |
NCT01398410 | Gastric Ulcers Duodenal Ulcers... More >> Caused by Low-dose Aspirin Less << | Phase 2 Phase 3 | Completed | - | - |
NCT02541786 | Helicobacter Pylori Infection | Phase 4 | Completed | - | Taiwan ... More >> Kaohsiung Medical University Hospital Kaohsiung, Taiwan, 807 Kaohsiung Veterans General Hospital Kaohsiung, Taiwan, 813 Less << |
NCT00838682 | - | Terminated(Terminated before t... More >>he complete enrollment due to slow enrollment) Less << | - | - | |
NCT01391715 | Gastroesophageal Reflux Diseas... More >>e Less << | Phase 3 | Withdrawn(patients could not b... More >>e recuited within study duration) Less << | December 2012 | Korea, Republic of ... More >> Haeundae Paik Hospital, Inje University School of Medicine Busan, Korea, Republic of, 612-030 Less << |
NCT00861640 | Nonvariceal Upper Gastrointest... More >>inal Bleeding Less << | Phase 4 | Unknown | April 2010 | Taiwan ... More >> Kaohsiung Medical University Hospital Recruiting Kaohsiung, Taiwan, 807 Contact: Chien-Yu Lu, MD 886-7-3121101 ext 7451 dr820188@pchome.com.tw Principal Investigator: Chien-Yu Lu, MD Less << |
NCT00236184 | - | Completed | - | - | |
NCT01140828 | Osteoarthritis ... More >> Arthritis, Rheumatoid Dyspepsia Less << | Phase 3 | Completed | - | China, Hong Kong ... More >> Prince of Wales Hospital Hong Kong, Hong Kong, China Less << |
NCT02767479 | H. Pylori Infection | Phase 3 | Completed | - | Japan ... More >> Hamamatsu University School of Medicine Hamamatsu, Shizuoka, Japan, 431-3192 Less << |
NCT03397680 | Helicobacter Pylori Infection | Phase 1 | Active, not recruiting | May 15, 2018 | Thailand ... More >> Thammasat University Hospital Khlong Luang, Patumthanee, Thailand, 12121 Less << |
NCT00844675 | Early Gastric Adenocarcinoma ... More >> Adenocarcinoma, Tubular Less << | Phase 4 | Completed | - | Korea, Republic of ... More >> Catholic University, Gangnam St. Mary's Hospital Seoul, Ban-po dong 505, Korea, Republic of, 137-040 Less << |
NCT02605395 | Gastrointestinal Diseases | Phase 4 | Completed | - | Egypt ... More >> GSK Investigational Site Cairo, Egypt Less << |
NCT02605395 | - | Completed | - | - | |
NCT00838682 | Peptic Ulcer Hemorrhage | Phase 4 | Terminated(Terminated before t... More >>he complete enrollment due to slow enrollment) Less << | - | Korea, Republic of ... More >> Bucheon St. Mary's Hospital Bucheon, Kyungkido, Korea, Republic of Uijeongbu St.Mary's Hospital Uijeongbu, Kyungkido, Korea, Republic of Less << |
NCT02986685 | Refractory Reflux Esophagitis | Phase 4 | Unknown | November 2017 | China, Shaanxi ... More >> Xijing Hosipital of Digestive Disease Recruiting Xi`an, Shaanxi, China, 710032 Contact: Yongquan Shi, professor 86-029-84771515 shiyquan@fmmu.edu.cn Less << |
NCT03802318 | Helicobacter Pylori Infection|... More >>Helicobacter Gastritis|Helicobacter-Associated Pyloric Ulcer Less << | UNKNOWN | 2025-12-20 | Chang-Gung memorial hospital a... More >>t Keelung, Keelung, 20401, Taiwan Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.78mL 0.56mL 0.28mL |
13.91mL 2.78mL 1.39mL |
27.82mL 5.56mL 2.78mL |