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Chemical Structure| 9050-30-0 Chemical Structure| 9050-30-0

Structure of Heparan Sulfate
CAS No.: 9050-30-0

Chemical Structure| 9050-30-0

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Heparan sulfate is a complex linear polysaccharide. It appears as a part of heparan sulfate proteoglycans and is abundantly expressed on the cell surface and in the extracellular matrix.

Synonyms: HS; Alpha-idosane; Tavidan

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Product Details of Heparan Sulfate

CAS No. :9050-30-0
Formula : C26H36N3O39S6
M.W : 1206.95
SMILES Code : NONE
Synonyms :
HS; Alpha-idosane; Tavidan
MDL No. :N/A

Safety of Heparan Sulfate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of Heparan Sulfate

RTK

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Human naive CD4+ T cells 20 µg/mL 5 days Ca10 did not directly affect Treg generation or expansion. PMC10687014
Human total blood dendritic cells (total DCs) 20 µg/mL 18 hours Ca10 stimulation increased the generation of CD4+CD127-CD25highFOXP3+ Tregs, which were highly suppressive. PMC10687014
Human monocyte-derived dendritic cells (hmoDCs) 20 µg/mL 18 hours Ca10 stimulation upregulated the expression of HLA-DR, CD86/CD83, and PD-L1, increased the production of TNF-α, IL-6, IL-1β, and IL-10, and promoted the generation of tolerogenic DCs. PMC10687014
Human embryonic kidney (EBNA 293) cells 25 µg/ml 16 hours To measure the GlcNAcT-II and GlcAT-II activities of EXTL3 ΔN PMC9178029
Mouse lung endothelial cells 50 μg/mL 24 hours Evaluate the enhancing effect of heparan sulfate oligosaccharides on CXCL10-mediated inhibition of cell proliferation PMC5588662

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.83mL

0.17mL

0.08mL

4.14mL

0.83mL

0.41mL

8.29mL

1.66mL

0.83mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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