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Chemical Structure| 2577-40-4 Chemical Structure| 2577-40-4
Chemical Structure| 2577-40-4

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H-Phe-Phe-OH, derives from L-phenylalanine, acts as a metabolite of human blood serum and mycoplasma genitalium.

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Product Details of H-PHE-PHE-OH

CAS No. :2577-40-4
Formula : C18H20N2O3
M.W : 312.36
SMILES Code : O=C(O)[C@@H](NC([C@@H](N)CC1=CC=CC=C1)=O)CC2=CC=CC=C2
MDL No. :MFCD00063154
InChI Key :GKZIWHRNKRBEOH-HOTGVXAUSA-N
Pubchem ID :6993090

Safety of H-PHE-PHE-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of H-PHE-PHE-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2577-40-4 ]

[ 2577-40-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 24424-99-5 ]
  • [ 2577-40-4 ]
  • [ 13122-90-2 ]
YieldReaction ConditionsOperation in experiment
71% With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20℃; for 3.5h; A solution of (Boc) 20 (800 mg, 3.5 mmol) in 1,4-dioxane (5 ML) was added to a cold (0 C) solution OF DI-L-PHE-PHE (1 g, 3.20 mmol) in 1,4-dioxane (6 mL) and 1N NAOH (3.3 mL). The mixture was stirred at 0-5 C FOR 2 hours. Another portion of (BOC) 20 (100 mg) was added and the mixture was stirred for an additional 60 minutes at 0-5 C then at room temperature for 30 minutes. The mixture was then evaporated to dryness. The solid was taken in a mixture of water/EtOAc and pH was adjusted to 2 with 2N HCI. The aqueous layer was extracted 3 times with EtOAc. The combined organic layers were dried with brine and the solvent was evaporated. Some solid was insoluble in a mixture of EtOAc/CHC13 : it was removed by filtration. The desired N Boc-L-Phe-L-Phe 1 was obtained as a white foamy solid (913.7 mg, 2.215 mmol, 71% yield).
  • 2
  • [ 13122-90-2 ]
  • [ 2577-40-4 ]
 

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