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Chemical Structure| 21187-98-4 Chemical Structure| 21187-98-4
Chemical Structure| 21187-98-4

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Gliclazide is a blocker of pancreatic β-cell ATP-sensitive potassium channels with IC50 of 184 nM in murine. It belongs to the sulfonylurea class of insulin secretagoguesIt. Gliclazide is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).

Synonyms: S1702; SE1702; S-852

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Product Details of Gliclazide

CAS No. :21187-98-4
Formula : C15H21N3O3S
M.W : 323.41
SMILES Code : O=S(C1=CC=C(C)C=C1)(NC(NN2CC3C(CCC3)C2)=O)=O
Synonyms :
S1702; SE1702; S-852
MDL No. :MFCD00409893
InChI Key :BOVGTQGAOIONJV-UHFFFAOYSA-N
Pubchem ID :3475

Safety of Gliclazide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312+P330-P501

Application In Synthesis of Gliclazide

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 21187-98-4 ]

[ 21187-98-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 58108-05-7 ]
  • [ 1694-06-0 ]
  • [ 21187-98-4 ]
YieldReaction ConditionsOperation in experiment
86% In toluene; for 3.0h;Reflux; To a 250 mL three-necked flask was added N-amino-3-azabicyclo [3.3.0] octane hydrochloride prepared in Example 6 (2)20 g of <strong>[1694-06-0]p-toluenesulfonylurea</strong>, 100 ml of toluene and heated under reflux for 3 hours. After the completion of the reaction,The toluene was distilled off under reduced pressure, 100 ml of water was added, and the crystals were stirred at room temperature for 12 hours. The solid was filtered,Recrystallization from ethyl acetate and drying under vacuum at 80 ° C for 15 h gave 37 g of product, yield 86percent.
 

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