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Chemical Structure| 202409-33-4 Chemical Structure| 202409-33-4

Structure of Etoricoxib
CAS No.: 202409-33-4

Chemical Structure| 202409-33-4

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Etoricoxib is a selective COX2 inhibitor with IC50 of 1.1 ± 0.1 μM and 116 ± 8 μM for COX1.

Synonyms: MK-0663; L-791456; Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663

4.5 *For Research Use Only !

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Product Details of Etoricoxib

CAS No. :202409-33-4
Formula : C18H15ClN2O2S
M.W : 358.84
SMILES Code : O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O
Synonyms :
MK-0663; L-791456; Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663
MDL No. :MFCD06797512
InChI Key :MNJVRJDLRVPLFE-UHFFFAOYSA-N
Pubchem ID :123619

Safety of Etoricoxib

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P262-P270-P280-P302+P352+P310
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Target
  • COX-2

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01638962 Osteoarthritis, Knee Not Applicable Completed - Denmark ... More >> University of Southern Denmark Odense, Region Syddanmark, Denmark, 5230 Less <<
NCT00092729 Dysmenorrhea Phase 3 Completed - -
NCT03117894 Breast Neoplasm Female ... More >> Regional Anesthesia Anesthesia Regional Anesthesia Morbidity Anesthesia Morbidity Less << Not Applicable Unknown December 2018 Sweden ... More >> Östersund Hospital Recruiting Östersund, Jämtland, Sweden, 83183 Contact: Hans Ahlberg, MD    +4663153000    hans.ahlberg@regionjh.se    Contact: Joakim Johansson, PhD    +46703976410    joakim.johansson@regionjh.se Less <<
NCT00716833 Pain Abdomina... More >>l Surgery Thoracic Surgery Less << Phase 3 Terminated(poor recruitment) - Germany ... More >> Zentrum für Pneumologie und Thoraxchirurgie, Asklepios Fachkliniken München-Gauting Gauting, Germany, 82131 Chirurgische Klinik und Poliklinik, Innenstadt, Klinikum der Universität München München, Germany, 80336 Less <<
NCT03011905 Brachial Plexus Block ... More >> Pain, Postoperative Less << Phase 3 Active, not recruiting April 5, 2019 Norway ... More >> Oslo Universitetssykehus, Ullevaal, dept of anaesthesiology, legevakten Oslo, Norway, 0540 Less <<
NCT02456363 Ankylosing Spondylitis Phase 2 Recruiting December 2019 Taiwan ... More >> Chung Shan Medical University Hospital Recruiting Taichung, Taiwan Contact: Cheng-Chung Wei, M.D., Ph.D.    24739595 ext 34718    wei3228@gmail.com Less <<
NCT01294696 - Completed - -
NCT01361789 Rupture of Anterior Cruciate L... More >>igament Less << Phase 4 Completed - Norway ... More >> Baerum Hospital Rud, Norway, 1309 Less <<
NCT02954484 Pain, Postoperative Phase 3 Completed - -
NCT01294696 - Completed - -
NCT02438709 Primary Hypertrophic Osteoarth... More >>ropathy Less << Phase 3 Unknown July 2016 China, Beijing ... More >> Peking Union Medical College Hospital Recruiting Beijing, Beijing, China, 100005 Contact: Weibo Xia, MD    86-10-6915-5076    xiaweibo@medmail.com.cn Less <<
NCT01398930 Knee Osteoarthritis Not Applicable Completed - Greece ... More >> National and Kapodistrian University Medical School Athens, Greece, 11527 Less <<
NCT01300780 Color Changes During Tooth For... More >>mation Less << Not Applicable Completed - Brazil ... More >> Universidade Estadual de Ponta Grossa Guarapuava, Paraná, Brazil, 84030900 Less <<
NCT00733421 Postoperative Pain Phase 4 Completed - Sweden ... More >> Foot & Ancle Surgical Center Stockholm, Sweden, 11542 Less <<
NCT00733421 - Completed - -
NCT00264147 Rheumatoid Arthritis Phase 2 Completed - -
NCT00092742 Rheumatoid Arthritis Phase 3 Completed - -
NCT00092703 Osteoarthritis Phase 3 Completed - -
NCT01017380 Anterior Cruciate Ligament Inj... More >>ury Less << Phase 3 Completed - Thailand ... More >> Prince of Songkla University Hat Yai, Songkhla, Thailand, 90110 Less <<
NCT00095017 Bone Neoplasms Phase 2 Withdrawn - -
NCT00092755 Osteoarthritis Phase 3 Completed - -
NCT00264147 - Completed - -
NCT00427999 Prostate Cancer Phase 2 Completed - Germany ... More >> Novartis Investigative Site Bad Reichenhall, Germany, 83435 Novartis Investigative Site Bonn, Germany, 53105 Novartis Investigative Site Hamburg, Germany, 20246 Novartis Investigative Site Hamburg, Germany, 22607 Novartis Investigative Site Kassel, Germany, 34131 Novartis Investigative Site Markkleeberg, Germany, 04416 Novartis Investigative Site Passau, Germany, 94032 Novartis Investigative Site Planegg, Germany, 82152 Novartis Investigative Site Regensburg, Germany, 93053 Novartis Investigative Site Tübingen, Germany, 72076 Less <<
NCT00970112 Pain Control Phase 2 Phase 3 Completed - Brazil ... More >> UEPG Ponta Grossa, Paraná, Brazil Less <<
NCT00427999 - Completed - -
NCT00380627 Pain Phase 4 Completed - -
NCT01304069 Healthy Phase 1 Completed - Finland ... More >> Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University and Turku University Hospital Turku, Finland Less <<
NCT00269191 Osteoarthritis Phase 3 Completed - -
NCT00092768 Osteoarthritis Phase 3 Completed - -
NCT00092781 Osteoarthritis Phase 3 Completed - -
NCT00694369 Postoperative Dental Pain Phase 3 Completed - -
NCT00792376 Achilles Tendinopathy Phase 4 Completed - Argentina ... More >> Argentine Tennis Association Buenos Aires, Argentina Less <<
NCT00694369 - Completed - -
NCT01269515 HIV PHASE2 COMPLETED 2025-11-14 Department of Infectious Disea... More >>ses, Oslo University Hospital, Oslo, 0407, Norway|The Biotechnology Centre, University of Oslo, Oslo, 0407, Norway Less <<
NCT01614301 Advanced Melanoma Phase 1 Phase 2 Unknown May 2016 Germany ... More >> University of Regensburg Recruiting Regensburg, Bavaria, Germany, 93053 Contact: Albrecht Reichle, Professor    +499419440    albrecht.reichle@UKR.de    Sub-Investigator: Martin Vogelhuber, MD          Sub-Investigator: Stephanie Mayer, MD          Sub-Investigator: Christina Hart, MD          Sub-Investigator: Matthias Grube, MD          Sub-Investigator: Susanne Gantner, MD Less <<
NCT02503839 Tuberculosis Phase 1 Recruiting December 2019 Norway ... More >> Haukeland University Hospital Recruiting Bergen, Norway, 5020 Contact: Tehmina Mustafa, PhD, MD    +47 97633677    tehmina.mustafa@uib.no    Oslo University Hospital Recruiting Oslo, Norway, 0424 Contact: Anne M Dyrhol-Riise, PhD, MD    +4792857261    a.m.d.riise@medisin.uio.no Less <<
NCT00393354 Recurrent Low Back Pain Phase 3 Completed - -
NCT03542955 Cervical Osteoarthritis Not Applicable Recruiting May 1, 2019 Lebanon ... More >> New Mazloum Hospital Recruiting Tripoli, Lebanon Contact: Omar Tabbouche, Pharm D    +9613433032    omartabbouche@gmail.com Less <<
NCT00393211 Recurrent Low Back Pain Phase 3 Completed - -
NCT00090181 Chronic Low Back Pain Phase 4 Completed - -
NCT00380523 Pain Phase 4 Completed - -
NCT00738608 - Completed - Germany ... More >> Marienkrankenhaus Soest, Germany, 59494 Less <<
NCT01980940 Osteoarthritis Pain Phase 1 Phase 2 Completed - -
NCT00542087 Osteoarthritis Phase 3 Completed - -
NCT01190722 Hallux Valgus ... More >> Postoperative Pain Less << Phase 4 Withdrawn(The study site was c... More >>losed down) Less << - -
NCT02884986 Adverse Anesthesia Outcome Not Applicable Completed - Israel ... More >> Bnai Zion Medical Center Haifa, Israel Less <<
NCT00525993 Sprains and Strains ... More >> Contusions Less << Phase 4 Unknown September 2009 Brazil ... More >> NEO Not yet recruiting São Paulo, SP, Brazil, 04084100 Contact: Rogerio Silva    011 81716767    rgtsilva@uol.com.br    Principal Investigator: Rogerio T Silva, MD, PhD          Sub-Investigator: Fabio C Petri, MD Less <<
NCT01002690 Asthma COMPLETED 2025-04-12 Karolinska University Hospital... More >>, Stockholm, SE-141 86, Sweden Less <<
NCT01077843 - Completed - -
NCT00140972 Osteoarthritis Phase 4 Completed - -
NCT03582332 Axial Spondyloarthritis Phase 4 Completed - -
NCT00242489 Osteoarthritis Phase 2 Completed - -
NCT00373464 Hysterectomy ... More >>Tubal Excision Ovariectomy Postoperative Pain Less << Phase 3 Completed - Norway ... More >> Ullevaal University Hospital Oslo, Norway Less <<
NCT00149253 a Single-Dose of Etoricoxib ... More >> Post-Operative Morphine Consumption Total Pain Relief Over 8 Hr(TOPAR8) Post Transabdominal Hysterectomy Less << Phase 3 Completed - Thailand ... More >> Warporn Chau-in KhonKaen University, KhonKaen, Thailand, 40002 Less <<
NCT00142558 Acute Gout Phase 4 Completed - -
NCT01979510 Low Back Pain Phase 3 Withdrawn May 2014 -
NCT01462370 Dysmenorrhea Phase 3 Completed - -
NCT01572675 - Completed - -
NCT01572675 - Completed - -
NCT01980940 - Completed - -
NCT00554346 Post-operational Pain Phase 4 Completed - Taiwan ... More >> National Taiwan University Hospital Taipei, Taiwan Less <<
NCT00250445 Rheumatoid Arthritis,Osteoarth... More >>ritis Less << Phase 3 Completed - -
NCT00954785 Sprain Phase 4 Withdrawn(The study was termin... More >>ated by Merck USA. The company did not supply drugs for the study.) Less << July 2011 South Africa ... More >> Kuilsriver Netcare Hospital, 33 Van Riebeeck Road, Kuilsriver Cape Town, Western Cape, South Africa, 7580 Sports Medicine Clinic, Sports Science Institute of South Africa Cape Town, Western Cape, South Africa, 7700 Less <<
NCT03422575 Healthy Not Applicable Completed - Indonesia ... More >> PT Equilab International Jakarta, Indonesia, 12430 Less <<
NCT01462370 - Completed - -
NCT00752921 Headache Phase 4 Unknown October 2008 Israel ... More >> Shaare Zedek Medical Center Not yet recruiting Jerusalem, Israel, 91031 Contact: Zev S Wimpfheimer, MD    972 50 868 5466    zevw@hotmail.com Less <<
NCT00793052 Trismus Edema... More >> Pain Less << Not Applicable Unknown December 2009 -
NCT00763685 Pain Phase 4 Terminated(The gynecological l... More >>aparoscopic surgery transition to day surgery made following the study protocol not possible.) Less << - Estonia ... More >> East Tallinn Central Hospital Tallinn, Estonia, 10138 Less <<
NCT00440739 Pain Phase 4 Completed - Thailand ... More >> Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand, 10700 Less <<
NCT01271348 Muscle Pain Phase 1 Completed - Germany ... More >> X-pert Med GmbH Jena, Germany, 07745 Less <<
NCT00876317 Soft Tissue Injuries of the Sh... More >>oulder Tenosynovitis and Bursitis Affecting the Shoulder Less << Phase 3 Terminated(Change in current a... More >>reas of research interest of the collaborator) Less << - Peru ... More >> Clínica Virgen Milagrosa Lima, Peru, Lima 34 Less <<
NCT00746720 Pain Osteoart... More >>hritis, Hip Postoperative Pain Less << Phase 2 Terminated(Patient recruitment... More >> difficulties) Less << - Germany ... More >> HELIOS Klinikum Berlin Berlin, Germany, D-13125 Less <<
NCT00799149 Knee Arthroscopy Phase 4 Completed - Israel ... More >> Meir Medical Center Kfar-Saba, Israel, 44281 Less <<
NCT00927004 Osteoarthritis ... More >> Pain Less << Phase 4 Completed - Australia, Western Australia ... More >> Royal Perth Hospital Perth, Western Australia, Australia, 6000 Less <<
NCT00565682 Laparoscopic Surgery for Appen... More >>dicitis Laparoscopic Surgery for Cholecystitis Laparoscopic Surgery for Ovarian Cysts Less << Phase 4 Completed - -
NCT01246362 Knee Osteoarthritis Phase 2 Completed - Singapore ... More >> Singapore General Hospital Singapore, Singapore, 169608 Less <<
NCT03697733 Abnormal Uterine Bleeding Not Applicable Not yet recruiting November 1, 2019 -
NCT00529594 Proliferative Diabetic Retinop... More >>athy Less << Not Applicable Completed - Brazil ... More >> Clinica Oftalmologica do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo São Paulo, SP, Brazil, 05403-000 Less <<
NCT00820027 Pain, Postoperative Phase 3 Completed - -
NCT00788710 Acute Pain Following a Total A... More >>bdominal Hysterectomy Less << Phase 3 Completed - -
NCT00788710 - Completed - -
NCT00855777 Dental Extraction Phase 4 Unknown April 2010 -
NCT00935116 Acute Pain Phase 4 Unknown September 2010 -
NCT01208207 - Completed - -
NCT01229774 Coxarthrosis ... More >>Arthroplasties Hip Replacement Perioperative Blood Loss Less << Phase 3 Completed - Germany ... More >> Department of Orthopedic Surgery Bad Abbach, Bavaria, Germany, 93077 Less <<
NCT00755521 Fibromyalgia Phase 4 Unknown December 2012 Israel ... More >> Department of Medicine 'D', Meir Medical Center Recruiting Kfar-Saba, Israel, 44281 Contact: Howard Amital, MD MHA    972-9-7472598    Howard.Amital@sheba.health.gov.il Less <<
NCT01619150 Osteoarthritis Phase 2 Completed - Denmark ... More >> CCBR A/S Aalborg, Denmark, 9000 Less <<
NCT01327638 - Completed - -
NCT01088256 Causalgia Pol... More >>yneuropathy Postherpetic Neuralgia Peripheral Nerve Injury Radiculopathy Less << Phase 2 Terminated - Germany ... More >> Bergmannsheil department of pain therapy Bochum, Nordrhein-Westfalen, Germany, 44789 Less <<
NCT00945035 - Completed - -
NCT01344720 Low Back Pain Phase 4 Unknown June 2011 Italy ... More >> Unità di riabilitazione neurofisiologica Istituto Scientifico di Riabilitazione di Montescano Not yet recruiting Montescano (PV), Pavia, Italy, 27040 Principal Investigator: Roberto Casale, Professore          Dipartimento di Scienze della Salute Anestesia, Rianimazione e Terapia del dolore - Università degli Studi di L'Aquila Ospedale San Salvatore L'Aquila Not yet recruiting L'Aquila, Italy, 67100 Principal Investigator: Franco Marinangeli, Dottore          Clinica Anestesia e Rianimazione Azienda Ospedaliera Universitaria Policlinico Tor Vergata Not yet recruiting Roma, Italy, 00133 Principal Investigator: Antonio Gatti, Dottore          Dipartimento Emergenza ed Accettazione Ospedale Civile G. Mazzini Teramo Not yet recruiting Teramo, Italy, 64100 Principal Investigator: Pier Luigi Orsini, Dottore          Dipartimento di Medicina Interna- Università degli Studi di Perugia Azienda Ospedaliera S.Maria - Clinica Medica Not yet recruiting Terni, Italy, 05100 Principal Investigator: Stefano Coaccioli, Professore Less <<
NCT01208207 Spondylitis, Ankylosing Phase 3 Completed - -
NCT00756873 Tonsillectomy Phase 3 Unknown December 2009 Germany ... More >> Universtiy Hospital Regensburg Not yet recruiting Regensburg, Germany, 93053 Contact: Michael Bucher, MD, PhD    xx49-941-944- ext 0    michael.bucher@klinik.uni.regensburg.de    Principal Investigator: Michael Bucher, MD, PhD          Sub-Investigator: Thomas Kühnel, MD, PhD          Weiden Clinic Not yet recruiting Weiden i.d. OPf., Germany, 92637 Contact: Jürgen Altmeppen, MD    xx49-9 61-303- ext 32 02    anaesthesie@klinikum-weiden.de    Principal Investigator: Jürgen Altmeppen, MD Less <<
NCT00945035 Pain Phase 1 Completed - -
NCT01429168 Osteoarthritis Phase 4 Withdrawn August 2012 -
NCT01148303 Headache Fast... More >>ing Fasting Headache Ramadan Headache Less << Phase 4 Completed - Israel ... More >> Shaare Zedek Medical Center Jerusalem, Israel Less <<
NCT01259830 Post-operative Pain Phase 4 Terminated - Germany ... More >> St. Hedwig Kliniken Berlin GmbH, Department of Anesthesiology and Intensive Care Medicine Berlin, Germany, 10115 Department of Anesthesiology, Sana-Klinikum Lichtenberg, Oskar-Ziethen-Krankenhaus Berlin, Germany, 10365 Department of Anesthesiology and Intensive Care Medicine, Campus Virchow Klinikum/Campus Charité Mitte, Charité Universitätsmedizin Berlin, Germany, 13353 Department of Anesthesiology, Johannes Wesling Klinikum Minden Mühlenkreiskliniken (AöR) Minden, Germany, 32429 Less <<
NCT00757627 Pain Phase 4 Completed - -
NCT00757627 - Completed - -
NCT01208181 - Completed - -
NCT02534610 Postoperative Pain Not Applicable Completed - Romania ... More >> Foisor Orthopedics Clinical Hospital Bucharest, Romania, 021382 Less <<
NCT01067430 Rheumatoid Arthritis Phase 4 Unknown April 2011 United Kingdom ... More >> Northumbria Healthcare NHS Foundation Trust Not yet recruiting North Shields, Tyne and Wear, United Kingdom, NE29 8NH Principal Investigator: David J Walker, MD Less <<
NCT01554163 - Completed - -
NCT01091675 Ankylosing Spondylitis PHASE3 COMPLETED 2025-05-13 Central Hospital of Asturias, ... More >>Oviedo, Asturias, 33006, Spain|Parc Tauli Hospital, Sabadell, Barcelona, Spain|Sant Rafael Hospital, Barcelona, 08035, Spain|Clinic I Provincial Hospital, Barcelona, 08036, Spain|Bellvitge Hospital, Barcelona, 08907, Spain|Reina Sofia University Hospital, Cordoba, 14004, Spain|Ramon Y Cajal Hospital, Madrid, 28034, Spain|University Hospital 12 Octubre, Madrid, 28041, Spain|Puerta de Hierro Hospital, Madrid, 28222, Spain|Hospital General of Mostoles, Madrid, 28935, Spain|University Hospital de la Princesa, Madrid, Spain|Virgen de la Arrixaca Hospital, Murcia, 30120, Spain|Hospital Clinic of Salamanca, Salamanca, 37007, Spain|Sant Pau i Santa Tecla Hospital, Tarragona, Spain Less <<
NCT02149758 Cyclooxygenase Two Inhibitors|... More >>Etoricoxib|Periodontitis|Superoxide Dismutase|Saliva Less << PHASE4 COMPLETED 2025-06-13 Tatyasaheb kore Dental College... More >> And Research Centre, Kolhapur, Maharashtra, 416137, India Less <<
NCT01264237 Postherpetic Neuralgia ... More >> Neuralgia Less << Phase 4 Unknown April 2012 United Kingdom ... More >> MAC (UK) Neruoscience Ltd Recruiting Liverpool, United Kingdom, L18 1HQ Principal Investigator: Stuart Ratcliffe, MBChB, MFPM, FRSM          MAC (UK) Neuroscience Ltd Recruiting Manchester, United Kingdom, M32 0UT Principal Investigator: Stuart Ratcliffe, MBChB, MFPM, FRSM Less <<
NCT01554163 Osteoarthritis of the Knee Phase 3 Completed - -
NCT02750917 Postoperative Pain Phase 3 Completed - -
NCT01685424 Osteoarthritis|Rheumatoid Arth... More >>ritis|Ankylosing Spondylitis|Gout|Arthritis Less << COMPLETED 2015-03-01 -
NCT01091675 Ankylosing Spondylitis PHASE3 COMPLETED 2025-05-13 Central Hospital of Asturias, ... More >>Oviedo, Asturias, 33006, Spain|Parc Tauli Hospital, Sabadell, Barcelona, Spain|Sant Rafael Hospital, Barcelona, 08035, Spain|Clinic I Provincial Hospital, Barcelona, 08036, Spain|Bellvitge Hospital, Barcelona, 08907, Spain|Reina Sofia University Hospital, Cordoba, 14004, Spain|Ramon Y Cajal Hospital, Madrid, 28034, Spain|University Hospital 12 Octubre, Madrid, 28041, Spain|Puerta de Hierro Hospital, Madrid, 28222, Spain|Hospital General of Mostoles, Madrid, 28935, Spain|University Hospital de la Princesa, Madrid, Spain|Virgen de la Arrixaca Hospital, Murcia, 30120, Spain|Hospital Clinic of Salamanca, Salamanca, 37007, Spain|Sant Pau i Santa Tecla Hospital, Tarragona, Spain Less <<
NCT01022190 - Completed - -
NCT01208181 Arthritis, Rheumatoid Phase 3 Completed - -
NCT02568735 Pain, Postoperative Phase 4 Completed - -
NCT01022190 Ossification, Heterotopic Phase 4 Completed - Netherlands ... More >> Radboud University Nijmegen Medical Center Nijmegen, Netherlands, 6500 HB Less <<
NCT04565600 Pain Syndrome PHASE2 COMPLETED 2021-06-28 Guangdong General Hospital, Gu... More >>angzhou, Guangdong, 510080, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.79mL

0.56mL

0.28mL

13.93mL

2.79mL

1.39mL

27.87mL

5.57mL

2.79mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

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