Structure of Erdafitinib
CAS No.: 1346242-81-6
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Erdafitinib inhibits FGFR1 (pIC50 = 9), FGFR2 (pIC50 = 8.5), FGFR3 (pIC50 = 8.5) and FGFR4 (pIC50 = 8.25) and it is a quinoxaline derivative compound.
Synonyms: JNJ-42756493
4.5
*For Research Use Only !
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 1346242-81-6 |
Formula : | C25H30N6O2 |
M.W : | 446.54 |
SMILES Code : | CN1N=CC(C2=NC3=CC(N(C4=CC(OC)=CC(OC)=C4)CCNC(C)C)=CC=C3N=C2)=C1 |
Synonyms : |
JNJ-42756493
|
MDL No. : | MFCD28502040 |
InChI Key : | OLAHOMJCDNXHFI-UHFFFAOYSA-N |
Pubchem ID : | 67462786 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
In Vitro:
Cell Line
|
Concentration | Treated Time | Description | References |
KB-C2 cells, HEK293/ABCB1 cells | 0.06µM, 0.2µM, 0.6µM | 72 h | Erdafitinib significantly enhanced the accumulation of drugs and inhibited the efflux from ABCB1 overexpressing cells, reversing MDR. | PMC7330633 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT06328491 | Ovarian Cancer|Steroid Cell Tu... More >>mor, Malignant Less << | COMPLETED | 2022-08-22 | Princess Margaret Cancer Centr... More >>e, Toronto, Ontario, M5G 2M9, Canada Less << | |
NCT02699606 | Neoplasm | PHASE2 | COMPLETED | 2024-03-15 | Beijing, China|Harbin, China|N... More >>anjing, China|Seoul, Korea, Republic of|Kaohsiung, Taiwan|Tainan, Taiwan Less << |
NCT03066687 | Healthy | PHASE1 | COMPLETED | 2017-05-12 | Celerion, Lincoln, Nebraska, 6... More >>8502, United States Less << |
NCT03825484 | Advanced Cancers and FGFR Gene... More >>tic Alterations Less << | APPROVED_FOR_MARKETING | - | - | |
NCT04917809 | Bladder Cancer|Recurrent Bladd... More >>er Cancer|FGFR3 Gene Mutation Less << | PHASE2 | RECRUITING | 2025-08-25 | Memorial Sloan Kettering Baski... More >>ng Ridge (Limited Protocol Activities), Basking Ridge, New Jersey, 07920, United States|Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown, New Jersey, 07748, United States|Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale, New Jersey, 07645, United States|Memorial Sloan Kettering Commack (Limited Protocol Activities), Commack, New York, 11725, United States|Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison, New York, 10604, United States|Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York, 10065, United States|Memorial Sloan Kettering Nassau (Limited Protocol Activities), Uniondale, New York, 11553, United States Less << |
NCT02692677 | Healthy | PHASE1 | COMPLETED | 2025-08-16 | Madison, Wisconsin, United Sta... More >>tes Less << |
NCT03587363 | Hepatic Impairment | PHASE1 | TERMINATED | 2020-12-22 | CRS Clinical Research Services... More >> Kiel GmbH, Kiel, 24105, Germany|APEX GmbH, Munchen, 81241, Germany Less << |
NCT04083976 | Advanced Solid Tumor | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-03-31 | Arizona Oncology Associates, P... More >>C - HOPE, Tucson, Arizona, 85711, United States|Rocky Mountain Cancer Centers, Colorado Springs, Colorado, 80907, United States|Memorial Cancer Institute, Hollywood, Florida, 33021, United States|Cancer Specialists of North Florida, Jacksonville, Florida, 32256, United States|Emory University, Atlanta, Georgia, 30022, United States|Hawaii Cancer Care, 'Aiea, Hawaii, 96701, United States|Maine Medical Center, Scarborough, Maine, 04074, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02215, United States|Henry Ford Hospital, Detroit, Michigan, 48202, United States|Hackensack University Medical Center, Hackensack, New Jersey, 07601, United States|Mount Sinai, New York, New York, 10029, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10128, United States|Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina, 28204, United States|Oncology Hematology Care, Cincinnati, Ohio, 45242, United States|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States|Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, United States|University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15232, United States|Tennessee Oncology, PLLC, Chattanooga, Tennessee, 37404, United States|Tennessee Oncology, Nashville, Tennessee, 37203, United States|Texas Oncology Baylor Charles A Sammons Cancer Center, Dallas, Texas, 75246, United States|Texas Oncology-Fort Worth Cancer Center, Fort Worth, Texas, 76104, United States|MD Anderson, Houston, Texas, 77030, United States|Oncology Consultants - Texas, Houston, Texas, 77030, United States|Texas Oncology Odessa-West Texas Cancer Center, Odessa, Texas, 79761, United States|Texas Oncology San Antonio Northeast, San Antonio, Texas, 78217, United States|NorthWest Medical Specialties, PLLC, Tacoma, Washington, 98405, United States|Aurora Research Institute, Wauwatosa, Wisconsin, 53226, United States|Hospital Aleman, Buenos Aires, C1118AAT, Argentina|Centro Oncológico Korben, Ciudad Autonoma de Buenos Aires, C1426AGE, Argentina|Instituto Fleni, Ciudad Autonoma de Buenos Aires, C1428AQK, Argentina|CEMIC Saavedra, Ciudad Autonoma de Buenos Aires, C1431FWN, Argentina|Instituto de Investigaciones Metabólicas, Ciudad Autónoma de Buenos Aires, C1012AAR, Argentina|Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica, Cordoba, 5000, Argentina|Hospital Italiano de La Plata, La Plata Lpl Lpl, 1900, Argentina|Instituto de Investigaciones Clinicas Mar del Plata, Mar Del Plata, Buenos Aires, B7600FZN, Argentina|Hospital Privado de Comunidad, Mar Del Plata, B7602CBM, Argentina|Hospital Universitario Austral, Pilar, 1629, Argentina|Sanatorio Britanico de Rosario, Rosario, 2000, Argentina|ARS Médica, San Salvador De Jujuy, Y4600AFW, Argentina|Flinders Centre for Innovation in Cancer, Adelaide, 5042, Australia|Chris O'Brien Lifehouse, Camperdown, 2050, Australia|St Vincent s Hospital Sydney, Darlinghurst, 2010, Australia|St Vincents Hospital Melbourne, Fitzroy, 3065, Australia|Fiona Stanley Hospital, Murdoch, 6150, Australia|Intergrated Clinical Oncology Network Pty Ltd (ICON), South Brisbane, 4101, Australia|AZ Klina, Brasschaat, 2930, Belgium|UCL Hopital Saint-Luc, Bruxelles, 1200, Belgium|Grand Hopital de Charleroi, site Notre Dame, Charleroi, 6000, Belgium|CHU UCL Namur - Site Dinant, Dinant, 5500, Belgium|UZA, Edegem, 2650, Belgium|AZ Maria Middelares, Gent, 9000, Belgium|UZ Gent, Gent, 9000, Belgium|Jolimont, Haine-Saint-Paul, La Louviere, 7100, Belgium|CHU UCL Namur - Site Sainte Elisabeth, Namur, 5000, Belgium|Cliniques St Pierre, Ottignies, 1340, Belgium|CHU UCL Namur - Site Godinne, Yvoir, 5530, Belgium|Fundacao Pio XII, Barretos, 14784-400, Brazil|Liga Paranaense de Combate ao Cancer, Curitiba, 81520 060, Brazil|Associacao de Combate ao Cancer em Goias - Hospital de Cancer Araujo Jorge, Goiania, 74605-070, Brazil|Associacao Hospital de Caridade Ijui, Ijui, 98700-000, Brazil|Liga Norte Riograndense Contra O Cancer, Natal, 59075-740, Brazil|Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, 90050-170, Brazil|Instituto de Medicina Integral Professor Fernando Figueira, Recife, 50070-550, Brazil|Oncoclinicas Rio de Janeiro S A, Rio de Janeiro, 22250 905, Brazil|Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro, 22281 100, Brazil|Hospital Sao Rafael, Salvador, 41253-190, Brazil|Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, 01246 000, Brazil|Fundacao Antonio Prudente A C Camargo Cancer Center, Sao Paulo, 01509 900, Brazil|Sociedade Beneficente de Senhoras - Hospital Sírio Libanês, S?o Paulo, 01308-901, Brazil|Real e Benemerita Associacao Portuguesa de Beneficencia, S?o Paulo, 01321-001, Brazil|Hospital Das Clinicas Da Faculdade De Medicina Da USP, S?o Paulo, 05410-030, Brazil|GRAACC, S?o Paulo, 4039001, Brazil|Cancer Hospital Chinese Academy of Medical Sciences, Beijing, 100021, China|Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China|Peking University Third Hospital, Beijing, 100191, China|Chinese PLA General Hospital, Beijing, 100853, China|Beijing Luhe Hospital, Capital Medical University, Beijing, 101100, China|Jilin cancer hospital, Changchun, 130012, China|The First Hospital of Jilin University, Changchun, 130021, China|West China Hospital,Sichuan University, Chengdu, 610041, China|Chongqing Southwest Hospital, Chongqing, 400038, China|Third Military Medical University Daping Hospital Cancer Center, Chongqing, 400042, China|Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510289, China|First affiliated Hospital of Zhejiang University, Hangzhou, 310003, China|Zhejiang Cancer Hospital, Hangzhou, 310022, China|Eastern Theater General Hospital, Qinhuai District Medical Area, Nanjing, 210002, China|Ruijin Hospital Shanghai Jiao Tong University, Shanghai, 200025, China|Cancer Hospital, FuDan University, Shanghai, 200032, China|Shanghai Zhongshan Hospital, Shanghai, 200032, China|Huashan Hospital Fudan University, Shanghai, 200040, China|Hopital Saint André, Bordeaux, 33075, France|Centre Francois Baclesse, Caen, 14000, France|Centre Jean Perrin, Clermont Ferrand, 63011, France|Centre Georges Fran?ois Leclerc, Dijon, 21000, France|Centre Oscar Lambret, Lille, 59020, France|Centre Leon Berard, Lyon, 69008, France|Hopital de la Timone, Marseille, 130005, France|Institut Curie, Paris, 75005, France|CHU De Poitiers, Poitiers, 86021, France|Institut de Cancérologie de Lorraine, Vandoeuvre lès Nancy, 54519, France|Institut Gustave Roussy, Villejuif, 94800, France|Charité, Berlin, 10115, Germany|Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden, Dresden, 01307, Germany|Universitaetsklinikum Essen, Essen, 45147, Germany|Universitaetsklinikum Frankfurt, Frankfurt, 60385, Germany|Asklepios Klinik Altona, Hamburg, 22763, Germany|Universitaetsklinikum Heidelberg, Heidelberg, 69120, Germany|Universitaetsklinikum Koeln, K?ln, 50937, Germany|Universitaetsklinikum Leipzig, Leipzig, 04103, Germany|Universit?tsmedizin der Johannes Gutenberg-Universit?t Mainz, Mainz, 55131, Germany|Klinikum rechts der Isar der TU Munchen, München, 81675, Germany|Universitatsklinikum Tubingen, Tübingen, 72076, Germany|Istituto Ortopedico Rizzoli, Bologna, 40136, Italy|ASST Grande Ospedale Metropolitano Niguarda, Milano, 20162, Italy|ASST di Monza, Monza, 20900, Italy|Azienda Ospedaliera Univ.- Università Degli studi della Campania - Luigi Vanvitelli, Napoli, 80138, Italy|Fondazione G Pascale Istituto Nazionale Tumori IRCCS, Napoli, 80138, Italy|Ospedale S. Maria Della Misericordia, Perugia, 06132, Italy|Ospedale Santa Chiara AO Universitaria Pisana, Pisa, 56126, Italy|Azienda Ospedaliera S. Maria Terni, Terni, 5100, Italy|Ospedale Borgo Roma, Verona, 37134, Italy|National Cancer Center Hospital, Chuo Ku, 104 0045, Japan|Hiroshima University Hospital, Hiroshima shi, 734 8551, Japan|National Cancer Center Hospital East, Kashiwa, 277 8577, Japan|National Hospital Organization Shikoku Cancer Center, Matsuyama, 791-0280, Japan|Fujita Health University Hospital, Toyoake, 470-1192, Japan|Severance Hospital Yonsei University Health System, Seoul, 03722, Korea, Republic of|Asan Medical Center, Seoul, 05505, Korea, Republic of|Samsung Medical Center, Seoul, 06351, Korea, Republic of|The Catholic University of Korea Seoul St Marys Hospital, Seoul, 06591, Korea, Republic of|Seoul National University Hospital, Seoul, 3080, Korea, Republic of|Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy, Bydgoszcz, 85-796, Poland|Przychodnia Lekarska KOMED Roman Karaszewski, Konin, 62-500, Poland|Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie, Krakow, 31-501, Poland|Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi, Lodz, 93 513, Poland|Centrum Medyczne Pratia Poznan, Skorzewo, 60-185, Poland|Instytut Matki i Dziecka, Warszawa, 01-211, Poland|Centralny Szpital Kliniczny MSWiA w Warszawie, Warszawa, 02-507, Poland|Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warszawa, 02-781, Poland|Hosp. Univ. Quiron Dexeus, Barcelona, 08028, Spain|Hosp Univ Vall D Hebron, Barcelona, 08035, Spain|Hosp Clinic de Barcelona, Barcelona, 08036, Spain|Hosp. Sant Joan de Deu, Barcelona, 08950, Spain|Inst. Cat. Doncologia-H Duran I Reynals, Hospitalet de Llobregat, Barcelona, 08908, Spain|Hosp. Infantil Univ. Nino Jesus, Madrid, 28009, Spain|Clinica Univ. de Navarra, Madrid, 28027, Spain|Hosp. Univ. Ramon Y Cajal, Madrid, 28034, Spain|Hosp Univ Fund Jimenez Diaz, Madrid, 28040, Spain|Hosp. Univ. 12 de Octubre, Madrid, 28041, Spain|Hosp. Univ. La Paz, Madrid, 28046, Spain|Hosp. Virgen Del Rocio, Sevilla, 41013, Spain|Hosp. Clinico Univ. de Valencia, Valencia, 46010, Spain|Changhua Christian Hospital, Changhua, 50006, Taiwan|E-Da Cancer Hospital, Kaohsiung City, 82445, Taiwan|Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, 807, Taiwan|Chang Gung Medical Foundation, Kaohsiung, 833, Taiwan|China Medical University Hospital, Taichung, 403, Taiwan|Taichung Veterans General Hospital, Taichung, 40705, Taiwan|Chi Mei Medical Center Yong Kang, Tainan, 710, Taiwan|National Cheng Kung University Hospital, Tainan, 710, Taiwan|Chi Mei Medical Center Liu Ying, Tainan, 736, Taiwan|National Taiwan University Hospital, Taipei, 10002, Taiwan|Taipei Veterans General Hospital, Taipei, 11217, Taiwan|Chang Gung Memorial Hospital Linkou Branch, Taoyuan City, 333, Taiwan|Bristol Royal Hospital for Children, Bristol, BS2 8AE, United Kingdom|Bristol Haematology and Oncology Centre, Bristol, BS2 8ED, United Kingdom|The Christie Nhs Foundation Trust, Manchester, M20 4BX, United Kingdom|Freeman Hospital, Newcastle upon Tyne, NE7 7DN, United Kingdom|Derriford Hospital, Plymouth, PL6 8DH, United Kingdom|The Royal Marsden NHS Trust, Sutton, SM2 5PT, United Kingdom|The Clatterbridge Cancer Centre, Wirral, CH63 4JY, United Kingdom Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.24mL 0.45mL 0.22mL |
11.20mL 2.24mL 1.12mL |
22.39mL 4.48mL 2.24mL |
Tags: Erdafitinib | JNJ-42756493 | JNJ42756493 | JNJ 42756493 | FGFR | Apoptosis | Fibroblast growth factor receptor | FGFR1 inhibitor | FGFR2 inhibitor | FGFR3 inhibitor | FGFR4 inhibitor | FGFR inhibitor | FGFR-altered cancer | urothelial carcinoma | 1346242-81-6
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H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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