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Chemical Structure| 605-65-2 Chemical Structure| 605-65-2
Chemical Structure| 605-65-2

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Dansyl chloride is a strong fluorescent agent that can be used to determine the amino terminus of a peptide chain. It can specifically react with the chain N-terminal α-amino group.

Synonyms: DNSCl; NSC 83616; Dansyl chloride, DNS-Cl, NSC 83616

4.5 *For Research Use Only !

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Product Details of Dansyl Chloride

CAS No. :605-65-2
Formula : C12H12ClNO2S
M.W : 269.75
SMILES Code : O=S(C1=C2C=CC=C(N(C)C)C2=CC=C1)(Cl)=O
Synonyms :
DNSCl; NSC 83616; Dansyl chloride, DNS-Cl, NSC 83616
MDL No. :MFCD00003985
InChI Key :XPDXVDYUQZHFPV-UHFFFAOYSA-N
Pubchem ID :11801

Safety of Dansyl Chloride

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of Dansyl Chloride

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 605-65-2 ]

[ 605-65-2 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 605-65-2 ]
  • [ 6893-02-3 ]
  • (R)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-propionic acid [ No CAS ]
  • 2
  • [ 605-65-2 ]
  • [ 35143-75-0 ]
  • 5-(Dimethylamino)-N-(4-methyl-5-isoxazolyl)-1-naphthalenesulfonamide [ No CAS ]
  • 3
  • [ 605-65-2 ]
  • [ 33084-49-0 ]
  • 5-Dimethylamino-N-(4-bromo-3-methyl-5-isoxazolyl)-1-naphthalenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
68% EXAMPLE 51 5-Dimethylamino-N-(4-bromo-3-methyl-5-isoxazolyl)-1 -naphthalenesulfonamide 5-Dimethylamino-N-(4-bromo-3-methyl-5-isoxazolyl)-1-naphthalenesulfonamide was prepared from <strong>[33084-49-0]5-amino-4-bromo-3-methylisoxazole</strong> and 5-dimethylaminonaphthalenesulfonyl chloride according to the procedures described in Example 5. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 87-89 C., yield 68%.
  • 5
  • [ 605-65-2 ]
  • [ 2576-47-8 ]
  • [ 606-25-7 ]
YieldReaction ConditionsOperation in experiment
86.1% With triethylamine; In tetrahydrofuran; EXAMPLE 11 Naphthalenesulfonamide, 5-(dimethylamino)-N-(2-bromoethyl) A suspension of 5-dimethylaminonaphthalene-1-sulfonyl chloride (50.0 g, 0.185 mol) and 2-bromoethylamine hydro-bromide (40.4 g, 0.197 mol) in THF (500 mL) was cooled to 2 C. A solution of triethylamine (38.5 g, 0.380 mol) in THF (250 mL) was added dropwise over a 2 h period while maintaining the internal temperature below 6 C. After complete addition the mixture was stirred at ambient temperature for 17 h. The mixture was clarified then concentrated to an orange oil which was chromatographed over silica (2.2 kg) packed and eluted with hexanes-EtOAc (3:1). Fractions (500 mL) containing the purified product were combined, clarified, then concentrated to a damp solid. This material was triturated in hexanes (250 mL), collected on a filter, washed with hexanes (50 mL) then dried to constant weight in vacuo at 40 C. to give 56.9 g (86.1% yield) of product as a off-white crystalline solid.
  • 6
  • [ 605-65-2 ]
  • [ 29390-67-8 ]
  • [ 189307-69-5 ]
  • 7
  • [ 605-65-2 ]
  • [ 152120-61-1 ]
  • tert-butyl ((5-(dimethylamino)naphthalene-1-sulfonamido)(1H-pyrazol-1-yl)methylene)carbamate [ No CAS ]
  • 8
  • [ 605-65-2 ]
  • [ 152120-61-1 ]
  • 5-(dimethylamino)-N-(N'-tert-butoxycarbonyl-N-(8-(4-(tert-butoxycarbonylimino)-2-oxo-1,3,5-triazacyclotridecan-1-yl)octyl)-carbamimidoyl)naphthalene-1-sulfonamide [ No CAS ]
 

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