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Chemical Structure| 1080622-86-1 Chemical Structure| 1080622-86-1

Structure of CP-466722
CAS No.: 1080622-86-1

Chemical Structure| 1080622-86-1

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CP-466722, a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.

4.5 *For Research Use Only !

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Product Details of CP-466722

CAS No. :1080622-86-1
Formula : C17H15N7O2
M.W : 349.35
SMILES Code : NC1=NC(C2=NC=CC=C2)=NN1C3=C4C=C(OC)C(OC)=CC4=NC=N3
MDL No. :MFCD17392566
InChI Key :ILBRKJBKDGCSCB-UHFFFAOYSA-N
Pubchem ID :44551660

Safety of CP-466722

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of CP-466722

DNA
PI3K-AKT

Isoform Comparison

Biological Activity

Target
  • ATM

    ATM, IC50:410 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
GBM12 cells 3 μM 14 days To evaluate the effect of CP-466722 on TMZ sensitivity, results showed that CP-466722 significantly sensitized GBM12 cells to TMZ PMC3535329
GBM12TMZ cells 3 μM 14 days To evaluate the effect of CP-466722 on TMZ sensitivity, results showed that CP-466722 had no significant effect on TMZ-resistant GBM12TMZ cells PMC3535329
HeLa cells 6μM 30 min To evaluate the inhibitory effect of CP466722 on ATM kinase activity, the results showed that CP466722 almost completely inhibited ATM cellular activity at concentrations of 6μM and above. PMC2559948
MCF-7 cells 6μM 30 min To evaluate the inhibitory effect of CP466722 on ATM kinase activity, the results showed that CP466722 inhibited ATM-dependent phosphorylation events. PMC2559948
RH-luciferase (RH-luc) strain 0.702 µM 72 h To evaluate the inhibitory effect of CP-466722 on the growth of T. gondii, the results showed that CP-466722 had a dose-dependent inhibitory effect on the proliferation of T. gondii, with an IC50 value of 0.702 µM. PMC11241798

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Nude mice Xenograft model Intraperitoneal injection 10 mg/kg Once daily for 8 weeks Inhibition of ATM expression significantly reduced tumor metastasis in A549CisR cells. PMC6454747
BALB/c mice T. gondii infection model Oral 20, 40, 60 mg/kg Once daily for 7 consecutive days To evaluate the protective effect of CP-466722 on T. gondii-infected mice, the results showed that CP-466722 had a slight protective effect on T. gondii-infected mice. PMC11241798

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.31mL

2.86mL

1.43mL

28.62mL

5.72mL

2.86mL

References

 

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