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Chemical Structure| 2349356-09-6 Chemical Structure| 2349356-09-6

Structure of BSJ-03-204
CAS No.: 2349356-09-6

Chemical Structure| 2349356-09-6

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BSJ-03-204 is a potent and selective Palbociclib-based CDK4/6 dual degrader (PROTAC), with IC50s of 26.9 nM and 10.4 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-03-204 does not induce IKZF1/3 degradation and has anti-cancer activity.

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Product Details of BSJ-03-204

CAS No. :2349356-09-6
Formula : C43H48N10O8
M.W : 832.90
SMILES Code : O=C(NCCCCN1CCN(C2=CN=C(C=C2)NC=3N=CC4=C(N3)N(C(=O)C(C(=O)C)=C4C)C5CCCC5)CC1)COC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8
MDL No. :MFCD33023229

Safety of BSJ-03-204

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of BSJ-03-204

Hedgehog

Isoform Comparison

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1 mM

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1.20mL

0.24mL

0.12mL

6.00mL

1.20mL

0.60mL

12.01mL

2.40mL

1.20mL

 

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