Structure of Apremilast
CAS No.: 608141-41-9
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Apremilast is a small molecule inhibitor of PDE4 with an IC50 value of 74 nM.
Synonyms: CC-10004; APR
4.5
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CAS No. : | 608141-41-9 |
Formula : | C22H24N2O7S |
M.W : | 460.50 |
SMILES Code : | CC(NC1=CC=CC(C(N2[C@@H](C3=CC=C(OC)C(OCC)=C3)CS(=O)(C)=O)=O)=C1C2=O)=O |
Synonyms : |
CC-10004; APR
|
MDL No. : | MFCD18782607 |
InChI Key : | IMOZEMNVLZVGJZ-QGZVFWFLSA-N |
Pubchem ID : | 11561674 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H361 |
Precautionary Statements: | P501-P202-P201-P280-P308+P313-P405 |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
Xenopus laevis oocytes | 1–10 μM | Apremilast did not directly alter GABA A receptor function | PMC7544627 | |
Natural killer (NK) cells | 10 μM | 48 h | Inhibited NK cell production of TNF-α and GM-CSF | PMC2829210 |
Polymorphonuclear cells (PMN) | 94 nM (IC50) | 18 h | Inhibited PMN production of IL-8 | PMC2829210 |
Draining lymph node cells | 200 nM | 72 h | To evaluate the effect of apremilast on balancing Treg and Teff cells. Results showed that apremilast significantly suppressed Th17 and Th1 cells and enhanced the proportion and population of Treg cells. | PMC7705241 |
CD4+CD25+ regulatory T cells | 0.1 µM | 24 h | To evaluate Apremilast's effect on Treg stability and conversion to Th17 cells. Results showed Apremilast pretreatment significantly increased Foxp3 expression, decreased IL-17a and CD126 expression, and maintained Treg suppressive function. | PMC6058600 |
ATDC5 chondrocytes | 1 µM | 7 days | Apremilast suppressed IL-17-induced cellular senescence, reducing SA-β-gal activity. | PMC7834959 |
ATDC5 chondrocytes | 0.5 and 1 µM | 24 h | Apremilast reduced the expression and secretion of IL-1β and MCP-1 induced by IL-17 in a dose-dependent manner. | PMC7834959 |
Human neonatal foreskin epidermal keratinocytes (HEKn cells) | 1 μM | 18 h | Inhibited UVB light-activated keratinocyte production of TNF-α | PMC2829210 |
Peripheral blood mononuclear cells (PBMC) | 10 μM | 18 h | Inhibited PBMC production of the chemokines CXCL9 and CXCL10, cytokines interferon-γ and tumour necrosis factor (TNF)-α, and interleukins (IL)-2, IL-12 and IL-23 | PMC2829210 |
Raw264.7 monocytic murine cell line | 104 nM (IC50) | 30 min | Apremilast increased intracellular cAMP and inhibited TNF-α release with an IC50 of 104 nM. | PMC4570588 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
C57BL/6J mice | BLM-induced systemic sclerosis (SSc) model | Oral | 25 mg/kg and 5 mg/kg | Once daily for 4 consecutive weeks | Apremilast significantly ameliorated the pathological manifestations of SSc, including skin dermal thickness, deposition of collagens, and increased expression of α-SMA | PMC8791980 |
C57BL/6J mice | Experimental autoimmune uveitis (EAU) model | Oral gavage | 15 mg/kg | Once daily for 14 days (from day 7 to day 21 after immunization) | To evaluate the therapeutic effect of apremilast on EAU. Results showed that apremilast significantly reduced vascular leakage, macular edema, and inflammatory cell infiltration in the retina, corresponding to decreased clinical and pathological scores. Additionally, apremilast decreased the proportion and population of Th17 cells and increased the proportion and population of Treg cells. | PMC7705241 |
DBA/1J mice | Collagen-induced arthritis (CIA) model | Oral | 5 mg/kg or 25 mg/kg | Once daily for 10 consecutive days | To assess therapeutic effects of Apremilast in CIA. Results demonstrated delayed arthritis onset, reduced clinical scores, decreased anti-CII antibodies, prevented bone erosion, and modulated Th1/Th17/Treg balance (decreased Th17/Th1, increased Treg). High dose (25 mg/kg) showed superior efficacy. | PMC6058600 |
Beige-severe combined immunodeficient mice | Mouse model xenotransplanted with normal human skin and triggered with human psoriatic NK cells | Oral | 5 mg/kg | Twice daily for 14 days | Significantly reduced epidermal thickness and proliferation, decreased the general histopathological appearance of psoriasiform features and reduced expression of TNF-α, human leukocyte antigen-DR and intercellular adhesion molecule-1 in the lesioned skin | PMC2829210 |
C57BL/6J mice | Models of ethanol- and other GABAergic drug-induced sedative-hypnotic effects and ataxia | Oral | 20 mg/kg | Once daily for 1 hour | Apremilast prolonged the sedative-hypnotic effects of ethanol, gaboxadol, zolpidem, and propofol and prolonged recovery from ataxia induced by ethanol, zolpidem, propofol, and loreclezole, but shortened the sedative-hypnotic and ataxic effects of diazepam. The PKA inhibitor H89 blocked these modulatory effects of apremilast. | PMC7544627 |
Mice | Β3-S408A/S409A knock-in mice | Oral | 20 mg/kg | Once daily for 1 hour | Apremilast increases acute sensitivity to alcohol, decreases AFT, and decreases ethanol drinking through PKA-dependent phosphorylation of β3 GABA A receptor subunits | PMC9810330 |
Mice | Murine air pouch model | Oral | 5 mg/kg | 24 hours and 1 hour before inflammation induction | Apremilast significantly inhibited TNF-α production in the air pouch by 39% and reduced leukocyte count by 28%. | PMC4570588 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT04175613 | Psoriasis | PHASE3 | ACTIVE_NOT_RECRUITING | 2027-02-22 | Phoenix Childrens Hospital, Ph... More >>oenix, Arizona, 85016, United States|Johnson Dermatology Clinic, Fort Smith, Arkansas, 72916, United States|First OC Dermatology, Irvine, California, 92697, United States|Stanford University School of Medicine, Palo Alto, California, 94304, United States|California Dermatology Institute, Thousand Oaks, California, 91320, United States|Solutions Through Advanced Research Inc, Jacksonville, Florida, 32256, United States|Ciocca Dermatology, Miami, Florida, 33173, United States|Skin Care Physicians of Georgia, Macon, Georgia, 31217, United States|Dawes Fretzin Dermatology Group Inc, Indianapolis, Indiana, 46256, United States|Wright State Physicians, Fairborn, Ohio, 45324, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States|Driscoll Childrens Hospital, San Antonio, Texas, 78218, United States|University of Wisconsin Hospital and Clinics, Madison, Wisconsin, 53715-1375, United States|Centre Hospitalier Universitaire Saint Pierre, Brussels, 1000, Belgium|Cliniques Universitaires Saint Luc, Brussels, 1200, Belgium|Universitair Ziekenhuis Gent, Gent, 9000, Belgium|Stollery Childrens Hospital, Edmonton, Alberta, T6G 2B7, Canada|Winnipeg Clinic Dermatology Research, Winnipeg, Manitoba, R3C 0N2, Canada|Karma Clinical Trials, St. John's, Newfoundland and Labrador, A1C 2H5, Canada|AvantDerm, Toronto, Ontario, M5A 3R6, Canada|Fakultni nemocnice Kralovske Vinohrady, Praha 10, 100 34, Czechia|Synexus Czech sro, Praha, 120 00, Czechia|Cabinet du Docteur Ruer-Mulard Mireille, Martigues, 13500, France|Centre Hospitalier Universitaire de Toulouse - Hopital Larrey, Toulouse, 31400, France|Soroka University Medical Center, Bear Sheva, 8410101, Israel|Azienda Ospedaliero Universitaria Di Cagliari, Cagliari, 09124, Italy|Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, 20122, Italy|Azienda Ospedaliera di Padova, Padova, 35020, Italy|Altai State Medical University, Barnaul, 656038, Russian Federation|Chelyabinsk Regional Clinical Skin and Venereal Dispensary, Chelyabinsk, 454048, Russian Federation|Ural Scientific Research Institute of Dermatovenereology and Immunopathology, Ekaterinburg, 620076, Russian Federation|Republican Clinical Dermatology and Venerology Dispensary, Kazan, 420012, Russian Federation|Clinical Dispensary of Dermatology and Venereology of Krasnodar Territory of the Ministry of Health, Krasnodar, 350020, Russian Federation|State Scientific Center for Dermatovenereology and Cosmetology, Moscow, 107076, Russian Federation|Moscow Scientific Practical Center of Dermatology Venerology and Cosmetology, Moscow, 119071, Russian Federation|National Medical Research Center for Children Health, Moscow, 119991, Russian Federation|LLC Medical Center Zdorovaya Semiya, Novosibirsk, 630099, Russian Federation|Pierre Wolkenshtein Skin Diseases Clinic LLC, Saint Petersburg, 191123, Russian Federation|Saint Petersburg State Pediatric Medical University, Saint Petersburg, 194100, Russian Federation|LLC PiterKlinika, Saint Petersburg, 196158, Russian Federation|Bashkiria State Medical University, Ufa, 450083, Russian Federation|Yarosavl State Medical Academy, Yaroslavl, 150000, Russian Federation|Hospital Sant Joan de Deu, Esplugues de Llobregat, Catalu?a, 08950, Spain|General University Hospital of Alicante, Alicante, 3010, Spain|Hopsital Germans Trias I Pujol, Badalona, 08916, Spain|Hospital General Universitario Gregorio Maranon, Madrid, 28007, Spain|Hospital Infantil Universitario Nino Jesus, Madrid, 28009, Spain|Hospital 12 de Octubre, Madrid, 28041, Spain|Hospital La Paz, Madrid, 28046, Spain|Hospital Marques de Valdecilla, Santander, 39008, Spain Less << |
NCT05863273 | Psoriasis | NOT_YET_RECRUITING | 2024-12-31 | China-Japan Friendship Hospita... More >>l, Beijing, China|the First Hospital of China Medical University, Shenyang, 110001, China Less << | |
NCT00869089 | Prurigo Nodularis | PHASE2 | COMPLETED | 2025-01-11 | University Hospitals Cleveland... More >> Medical Center, Cleveland, Ohio, 44106, United States Less << |
NCT03000309 | Plaque Psoriasis | PHASE4 | COMPLETED | 2018-04-25 | DermResearch, PLLC, Louisville... More >>, Kentucky, 40217, United States Less << |
NCT03422640 | Frontal Fibrosing Alopecia | PHASE4 | UNKNOWN | 2025-01-19 | Bellevue Dermatology, Bellevue... More >>, Washington, 98004, United States Less << |
NCT03191539 | Arthritis; Psoriasis (Etiology... More >>) Less << | PHASE3 | UNKNOWN | 2019-06-14 | - |
NCT05565560 | Plaque Psoriasis | PHASE3 | RECRUITING | 2026-09-06 | Nagoya City University Hospita... More >>l, Nagoya-shi, Aichi, 467-8602, Japan|Fukuoka University Hospital, Fukuoka-shi, Fukuoka, 814-0180, Japan|Hospital of the University of Occupational and Environmental Health Japan, Kitakyushu-shi, Fukuoka, 807-8556, Japan|Kurume University Hospital, Kurume-shi, Fukuoka, 830-0011, Japan|Fukushima Medical University Hospital, Fukushima-shi, Fukushima, 960-1295, Japan|Gifu University Hospital, Gifu-shi, Gifu, 501-1194, Japan|Gunma University Hospital, Maebashi-shi, Gunma, 371-8511, Japan|Takagi Dermatological Clinic, Obihiro-shi, Hokkaido, 080-0013, Japan|Hokkaido University Hospital, Sapporo-shi, Hokkaido, 060-8648, Japan|Kanazawa Medical University Hospital, Kahoku-gun, Ishikawa, 920-0293, Japan|Takeoka Dermatology Clinic, Marugame-shi, Kagawa, 763-0074, Japan|Takamatsu Red Cross Hospital, Takamatsu-shi, Kagawa, 760-0017, Japan|Saruwatari Dermatology Clinic, Kagoshima-shi, Kagoshima, 890-0046, Japan|Tokai University Hospital, Isehara-shi, Kanagawa, 259-1193, Japan|St Marianna University Hospital, Kawasaki-shi, Kanagawa, 216-8511, Japan|University Hospital Kyoto Prefectural University of Medicine, Kyoto-shi, Kyoto, 602-8566, Japan|Shinshu University Hospital, Matsumoto-shi, Nagano, 390-8621, Japan|Nagasaki University Hospital, Nagasaki-shi, Nagasaki, 852-8501, Japan|University of the Ryukyus Hospital, Ginowan-shi, Okinawa, 901-2725, Japan|Kansai Medical University Hospital, Hirakata-shi, Osaka, 573-1191, Japan|Nippon Life Hospital, Osaka-shi, Osaka, 550-0006, Japan|Kindai University Hospital, Osakasayama-shi, Osaka, 589-8511, Japan|Dokkyo Medical University Hospital, Shimotsuga-gun, Tochigi, 321-0293, Japan|Sugai Dermatology Park Side Clinic, Utsunomiya-shi, Tochigi, 321-0954, Japan|St Lukes International Hospital, Chuo-ku, Tokyo, 104-8560, Japan|Teikyo University Hospital, Itabashi-ku, Tokyo, 173-8606, Japan|Mita Dermatology Clinic, Minato-ku, Tokyo, 108-0014, Japan|Seibo International Catholic Hospital, Shinjuku-ku, Tokyo, 161-8521, Japan|Tokyo Medical University Hospital, Shinjyuku-ku, 160-0023, Japan Less << |
NCT01634178 | Healthy Volunteer | PHASE1 | COMPLETED | 2012-03-01 | PPD Development, Austin, Texas... More >>, 787844, United States Less << |
NCT04161456 | Acne Conglobata | PHASE2 | COMPLETED | 2021-02-08 | University Hospital Frankfurt,... More >> Frankfurt, Hessia, 60590, Germany Less << |
NCT03608657 | Arthritis, Psoriatic | COMPLETED | 2022-03-30 | The Waterside Clinic, Barrie, ... More >>L4M 6L2, Canada|The Arthritis and Osteoporosis Centre, Burlington, L7L 0B7, Canada|Adachi Medicine Professional Corporation, Hamilton, L8N 1Y2, Canada|Credit Valley Rheumatology, Mississauga, L5M 2V8, Canada|Institut de Recherche en Rhumatologie de Montréal, Montreal, H2L 1S6, Canada|Applied Medical Informatics Research Inc. (A.M.I.R.), Montreal, H4A 3T2, Canada|Brent Appleton Clinic New Westminster, New Westminster, V6Z 2C7, Canada|Dr. A. M. Jaroszynska Rheumatology and Osteoporosis Clinic, Oakville, L6M 4J2, Canada|Drs M&W Teo, Penticton, V2A 4Z1, Canada|Groupe de recherche en maladies osseuses Inc., Quebec, G1V 3M7, Canada|Centre de Rhumatologie de l'Est du Quebec, Rimouski, G5L 8W1, Canada|Polmed Research Inc., Saskatoon, S7N 4A4, Canada|Clinique Jacques Cartier, Sherbrooke, J1J 2E3, Canada|St. Clare's Mercy Hospital, St John's, A1A 5B8, Canada|Dr. Juris Lazovskis Incorporated, Sydney, B1S 3N1, Canada|Toronto Western Hospital, University Health Network, Toronto, M5T 2S8, Canada|Arthur Karasik Medicine Professional Inc., Toronto, M9C 5N2, Canada|Dr. Jonathan D. Chan Inc., Vancouver, V5Z 1J9, Canada|Dr. Sabeen Anwar Medicine Professional Corporation, Windsor, N8X 5A6, Canada Less << | |
NCT02576678 | Psoriasis | PHASE2 | COMPLETED | 2019-07-29 | Rady Children's Hospital, San ... More >>Diego, California, 92123, United States|Emory University, Atlanta, Georgia, 30322, United States|Ann & Robert H. Lurie Children's Hospital of Chicago Department of Dermatology, Chicago, Illinois, 60611, United States|Dundee Dermatology, West Dundee, Illinois, 60118, United States|Mount Sinai, St. Luke's, New York, New York, 10025, United States|Texas Dermatology and Laser Specialists, San Antonio, Texas, 78218, United States|Stollery Children's Hospital, Edmonton, Alberta, T6G 2B7, Canada|Nexus Clinical Research, St John's, Newfoundland and Labrador, A1A 5E8, Canada|CHU Saint-Justine, Montreal, Quebec, H3T 1C5, Canada|Rheinische Friedrich-Wilhelms-Universitaet Bonn - Universitaetsklinikum Bonn, Bonn, 53127, Germany|Universitatsklinikum Essen, Essen, 45147, Germany|Universitatsklinikum Klinikum Frankfurt Main, Frankfurt, 60590, Germany|Kinderkrankenhaus Wilhelmstift, Dermatologie, Hamburg, 22149, Germany|Universit?tsmedizin der Johannes Gutenberg-Universit?t Mainz, Mainz, 55131, Germany|Muenster University Hospital (Universit?tsklinikum Muenster), Munster, 48149, Germany|Hospital de la Santa Creu i Sant Pau, Barcelona, 08041, Spain|Hospital Sant Joan de Deu, Esplugues de Llobregat, 08950, Spain|Hospital La Paz, Madrid, 28046, Spain Less << |
NCT03828045 | Arthritis, Psoriatic | COMPLETED | 2021-10-20 | H Son Espases, Mallorca, Balea... More >>res, 07120b, Spain|H Son Llatzer, Mallorca, Baleares, 07198, Spain|H Univ Canarias, Tenerife, Canarias, 38320, Spain|H Parc Tauli, Barcelona, Catalu?a, 08208, Spain|H Bellvitge, L'Hospitalet Del Llobregat, Catalu?a, 8907, Spain|H Santa Maria Lleida, Lérida, Catalu?a, 25198, Spain|H Joan XXIII, Tarragona, Catalu?a, 43005, Spain|H Mérida, Badajoz, Extremadura, 06800, Spain|H Virgen del Puerto, Caceres, Extremadura, 10600, Spain|H Virgen de la Arrixaca, El Palmar, Murcia, 30120, Spain|H Navarra, Pamplona, Navarra, 31008, Spain|H Txagorritxu de Vitoria, Vitoria, País Vasco, 01009, Spain|H Perpetuo Socorro, Badajoz, 06010, Spain|H Del Mar, Barcelona, 08003, Spain|H Donostia, Donostia, 20014, Spain|H Can Misses, Eivissa, 07800, Spain|H Santa Lucía, Murcia, 30202, Spain|H Monte Naranco, Oviedo, 33012, Spain|H l Esperit Sant, Santa Coloma de Gramenet, 08923, Spain|Universitaire Vaudoise*, Vigo, 36213, Spain Less << | |
NCT04572997 | Palmoplantar Pustulosis | PHASE2 | COMPLETED | 2019-08-29 | University Hospital Bonn, Bonn... More >>, 53127, Germany|Universit?tsmedizin G?ttingen / Georg-August-Universit?t Department for Dermatology, Venereology and Allergology, G?ttingen, 37075, Germany|SCIderm GmbH, Hamburg-Harburg, 20354, Germany|Universit?tsklinik Schleswig-Holstein, Campus Kiel, PSORIASIS-ZENTRUM KIEL, Klinik für Dermatologie, Venerologie und Allergologie, Kiel, 24105, Germany|Universit?tsklinikum Münster Klinik für Hautkrankheiten, Münster, 48149, Germany Less << |
NCT03097003 | Psoriasis | COMPLETED | 2018-12-20 | AZ Sint Jan, Brugge, 8000, Bel... More >>gium|CHU St Pierre, Brussels, 1000, Belgium|CHU Brugmann (Victor Horta), Brussels, 1020, Belgium|Clin Univ de Bxl H?pital Erasme, Brussels, 1070, Belgium|UZ Brussel, Brussels, 1090, Belgium|Cliniques Universitaires St-Luc, Brussels, 1200, Belgium|UZ Antwerpen, Edegem, 2650, Belgium|Private Practice Geel, Geel, 2440, Belgium|Private Practice Genk, Genk, 3600, Belgium|AZ Sint Lucas, Gent, 9000, Belgium|UZ Gent, Gent, 9000, Belgium|CHU UCL Mont-Godinne, Godinne, 5530, Belgium|Clinique André Renard d'Herstal, Herstal, 4040, Belgium|Private Practice Lede, Lede, 9340, Belgium|UZ Leuven Sint Rafael, Leuven, 3000, Belgium|CHU Sart-Tilman, Liège, 4000, Belgium|GHdC - site IMTR, Loverval, 6280, Belgium|Dermatologie Maldegem, Malgegem, 9990, Belgium|Private Practice Mons, Mons, 7000, Belgium|Private Practice Namur, Namur, 5000, Belgium|Ste Elisabeth - Namur, Namur, 5000, Belgium|CH Bois Abbaye-Hesbaye, Seraing, 4100, Belgium Less << | |
NCT03740516 | Bechet's Disease | NO_LONGER_AVAILABLE | - | Celgene, Summit, New Jersey, 0... More >>7901, United States Less << | |
NCT03757013 | Psoriasis | COMPLETED | 2021-09-10 | Private Practice, Amiens, Amie... More >>ns, 80000, France|Saint-Joseph Clinic, Angouleme, Angouleme, 16000, France|Private Practice, Antibes, Antibes, 06600, France|Private Practice 2, Antony, Antony, 92160, France|Private Practice 2, Arcachon, Arcachon, 33120, France|Private Practice, Argenteuil, Argenteuil, 95100, France|Private Practice, Aubière, Aubière, 63170, France|Private Practice, Auch, Auch, 32000, France|Auxerre Hospital, Auxerre, 89000, France|Henri Duffaut Hospital, Avignon Cedex 9, 84902, France|Private Practice, Besan?on, Besan?on, 25000, France|Reims-Bezannes Polyclinic 2, Bezannes, 51430, France|Reims-Bezannes Polyclinic 3, Bezannes, 51430, France|Reims-Bezannes Polyclinic, Bezannes, 51430, France|Private Practice, Biarritz, Biarritz, 64200, France|Private Practice, Bordeaux, Bordeaux, 33000, France|Docteur Duchenne Hospital 2, Boulogne-sur-Mer, 62321, France|Docteur Duchenne Hospital, Boulogne-sur-Mer, 62321, France|Private Practice, Bègles, Bègles, 33130, France|Private Practice 2, Caen, Caen, 14000, France|Private Practice 3, Caen, Caen, 14000, France|Private Practice, Caen, Caen, 14000, France|Private Practice, Cannes, Cannes, 06400, France|Private Practice 2, Chalons-en-Champagne, Chalons-en -Champagne, 51000, France|Private Practice, Chalons-en-Champagne, Chalons-en-Champagne, 51000, France|Chalons-en-Champagne Hospital, Chalons-en-Champagne, 51005, France|Private Practice, Chamalières, Chamalières, 63400, France|Trousseau Hospital, Chambray-Les-Tours Cedex, 37171, France|Métropole Savoie Hospital, Chambéry, 73000, France|Private Practice 2, Chartres, Chartres, 28000, France|Private Practice, Chartres, Chartres, 28000, France|New Sud Francilien Hospital, Corbeil Essonnes, 91100, France|GH de Dax, Dax, Dax, 40107, France|Private Practice 2, Dijon, Dijon, 21000, France|Private Practice 3, Dijon, Dijon, 21000, France|Private Practice, Dijon, Dijon, 21000, France|Private Practice, Dole, Dole, 39100, France|Victor Jousselin Hospital, Dreux, 28102, France|Emile Durkheim Hospital - Saint Jean Health Center, Epinal Cedex, 88021, France|Private Practice, Essey-les-Nancy, Essey-les-Nancy, 54270, France|Golfe de St-Tropez Clinic, Gassin, 83580, France|Private Practice 2, Joue les Tours, Joue les Tours, 37300, France|Private Practice 3, Joue les Tours, Joue les Tours, 37300, France|Private Practice, Joue les Tours, Joue les Tours, 37300, France|Private Practice, L'Union, L'Union, 31240, France|Private Practice 2, La Teste-de-Buch, La Teste-de-Buch, 33260, France|Private Practice, La Teste-de-Buch, La Teste-de-Buch, 33260, France|Private Practice, La Valette du Var, La Valette du Var, 83160, France|Private Practice, La Varenne Saint Hilaire, La Varenne Saint Hilaire, 94210, France|Private Practice 2, Laval, Laval, 53000, France|Private Practice, Laval, Laval, 53000, France|Private Practice, Le Mans, Le Mans, 72000, France|Mans Hospital 2, Le Mans, 72037, France|Mans Hospital, Le Mans, 72037, France|Private Practice, Le-Bourget-du-Lac, Le-Bourget-du-Lac, 73370, France|Private Practice, Lille, Lille, 59000, France|Private Practice 2, Luce, Luce, 28110, France|Private Practice, Luce, Luce, 28110, France|Private Practice, Lyon, Lyon, 69002, France|Edouard Herriot Hospital, Lyon, 69003, France|Private Practice 2, Lyon, Lyon, 69006, France|Private Practice 4, Lyon, Lyon, 69008, France|Private Practice, Martigues, Martigues, 13500, France|Annecy Genevois Hospital, Metz Tessy, Metz Tessy, 74370, France|Private Practice, Meudon-la-Forêt, Meudon-la-Forêt, 92360, France|Private Practice, Muret, Muret, 31600, France|Hotel Dieu Hospital, Dermatologic Clinic, Nantes, 44093, France|Private Practice, Narbonne, Narbonne, 11100, France|Private Practice, Nevers, Nevers, 58000, France|Private Practice 2, Nice, Nice, 06000, France|Private Practice 3, Nice, Nice, 06000, France|Private Practice, Nogent-Le-Rotrou, Nogent-Le-Rotrou, 28400, France|Private Practice, Orléans, Orléans, 45000, France|Private Practice, Paris, Paris, 75005, France|Private Practice 2, Paris, Paris, 75006, France|Private Practice 3, Paris, Paris, 75008, France|Private Practice 4, Paris, Paris, 75009, France|Private Practice 5, Paris, Paris, 75010, France|Private Practice, Pontarlier, Pontarlier, 25300, France|Private Practice, Pontoise, Pontoise, 95300, France|Private Practice, Quimper, Quimper, 29000, France|CHI de Cornouaille - Laennec, Quimper, 29107, France|Mathilde II Clinic, Rouen, 76100, France|Private Practice, Saint-Etienne, Saint-Etienne, 42000, France|Saint-Etienne Hospital, St Priest en Jarez, 42277, France|Private Practice, Torcy, Torcy, 77200, France|BCRM Toulon - HIA Saint-Anne, Toulon Cedex 9, 83800, France|Private Practice, Toulouse, Toulouse, 31000, France|Nord Franche-Comté Hospital, Trevenans, 90400, France|Valence Hospital 2, Valence, 26953, France|Valence Hospital 3, Valence, 26953, France|Valence Hospital, Valence, 26953, France|Jacques Lacarin Hospital, Vichy, 03201, France Less << | |
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NCT01140503 | Dermatomyositis | TERMINATED | 2025-09-11 | Stanford University School of ... More >>Medicine, Stanford, California, 94305, United States Less << | |
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NCT03082729 | Psoriasis|Cardiovascular Disea... More >>ses Less << | PHASE4 | COMPLETED | 2021-08-17 | University of Southern Califor... More >>nia, Los Angeles, California, 90033, United States|Derm Associates, P.C., Rockville, Maryland, 20850, United States|Buffalo Medical Group, P.C., Buffalo, New York, 14221, United States|Oregon Medical Research Center, Portland, Oregon, 97223, United States|Dermatology and Skin Surgery Center, Exton, Pennsylvania, 19341, United States|The University of Pennsylvania, Philadelphia, Pennsylvania, 19140, United States|Center for Clinical Studies, Houston, Texas, 77004, United States Less << |
NCT03783026 | Psoriatic Arthritis | PHASE4 | COMPLETED | 2022-05-11 | The Doctors of Saint John's Me... More >>dical Group, Santa Monica, California, 90404, United States|Inland Rheumatology Clinical Trials Inc, Upland, California, 91786, United States|Malcom Randall VA Medical Center, Gainesville, Florida, 32610, United States|Integral Rheumatology and Immunology Specialists, Plantation, Florida, 33324, United States|NYU Langone Medical Center, New York, New York, 10003, United States|Austin Regional Clinic, Austin, Texas, 78731, United States|Swedish Medical Center, Seattle, Washington, 98104, United States|Medizinische Universitat Wien, Vienna, 1090, Austria|UZ Leuven, Leuven, 3000, Belgium|University of Calgary - Cumming School of Medicine, Calgary, Alberta, T2N 4N1, Canada|Alberta Rheumatology, Edmonton, Alberta, T5M 0H4, Canada|Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 7W9, Canada|G.R.M.O. (Groupe de recherche en maladies osseuses) Inc., Quebec, G1V 3M7, Canada|Aalborg Universitetshospital, Aalborg, 9000, Denmark|Frederiksberg Hospital, Frederiksberg, 2000, Denmark|Copenhagen University Hospital Rigshospitalet, Glostrup, 2600, Denmark|Universitaetsklinikum Bonn, Bonn, 53127, Germany|Universitaetsklinikum Duesseldorf, Duesseldorf, 40225, Germany|Johann Wolfgang Goethe University Hospital, Frankfurt am Main, 60590, Germany|Universitaetsklinikum Tuebingen, Tuebingen, 72076, Germany|Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele Ospedale Vittorio Emanuele, Catania, 95123, Italy|Azienda Ospedaliera Regionale San Carlo, Potenza/Matera, 85100, Italy|Udmurt Republic Republican Clinical Diagnostic Center, Izhevsk, 426009, Russian Federation|Research Institute of Rheumatology named after V.A.Nasonova, Moscow, 115522, Russian Federation|LLC Medical Center Zdorovaya Semiya, Novosibirsk, 630061, Russian Federation|Mechnikov North-Western State Medical University, Saint-Petersburg, 191015, Russian Federation|Regional Clinical Hospital No 1 - Tyumen, Tyumen, 625032, Russian Federation|Hospital Virgen de Macarena, Sevilla, Andalucía, 41009, Spain|Hospital Santa Creu I Sant Pau, Barcelona, 08041, Spain|Hospital La Paz, Madrid, 28046, Spain|Kantonsspital Aarau - KSA, Aarau, 5001, Switzerland|Hopital Universitaire Genevois - Beau-Sejour Hospital, Geneve, 1206, Switzerland|Kantonsspital St Gallen, Sankt Gallen, 9007, Switzerland|NHS Lothian, Western General Hospital, Edinburgh, EH16 4TJ, United Kingdom|The Leeds Teaching Hospitals NHS Trust - Chapel Allerton Hospital, Leeds, LS7 4SA, United Kingdom|Southampton University Hospitals NHS Trust, Southampton, SO16 6YD, United Kingdom Less << |
NCT04306965 | Atopic Dermatitis | PHASE2 | COMPLETED | 2022-08-18 | Tufts Medical Center, Departme... More >>nt of Dermatology, Boston, Massachusetts, 02111, United States Less << |
NCT00814632 | Vulvodynia | PHASE2 | COMPLETED | 2025-02-11 | William Beaumont Hospital, Roy... More >>al Oak, Michigan, 48073, United States Less << |
NCT00701311 | Prostatitis|Chronic Prostatiti... More >>s With Chronic Pelvic Pain Syndrome Less << | PHASE2 | COMPLETED | 2025-03-11 | William Beaumont Hospital, Roy... More >>al Oak, Michigan, 48073, United States Less << |
NCT03022617 | Psoriatic Nail|Psoriasis Vulga... More >>ris|Psoriasis Less << | PHASE4 | COMPLETED | 2022-09-29 | The Kirklin Clinic, Birmingham... More >>, Alabama, 35249, United States Less << |
NCT00889421 | Uveitis | PHASE1|PHASE2 | TERMINATED | 2025-06-11 | Oregon Health & Science Univer... More >>sity, Portland, Oregon, 97239, United States Less << |
NCT00521339 | Psoriasis-Type Psoriasis|Plaqu... More >>e-Type Psoriasis Less << | PHASE2 | COMPLETED | 2009-05-01 | Tufts-New England Medical Cent... More >>er Hospitals, Boston, Massachusetts, 02111, United States|Central Dermatology, Saint Louis, Missouri, 63117, United States|Oregon Medical Research Center, P.C., Portland, Oregon, 97223, United States|Baylor Research Institute, Dallas, Texas, 75246-1613, United States Less << |
NCT03521687 | Central Centrifugal Cicatricia... More >>l Alopecia Less << | PHASE4 | COMPLETED | 2021-02-12 | Mount Sinai West Dermatology, ... More >>New York, New York, 10023, United States Less << |
NCT03616561 | Nail Psoriasis | COMPLETED | 2020-07-23 | Hospital General de Granollers... More >>, Granollers, Barcelona, 08402, Spain Less << | |
NCT06088199 | Plaque Psoriasis | PHASE3 | RECRUITING | 2026-12-17 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35233, United States|Affiliated Dermatology, Scottsdale, Arizona, 85255, United States|Clear Dermatology, Scottsdale, Arizona, 85255, United States|Johnson Dermatology Clinic, Fort Smith, Arkansas, 72916, United States|Avance Clinical Trials, Laguna Niguel, California, 92677, United States|University of California Irvine, Orange, California, 92868, United States|MedDerm Associates, San Diego, California, 92103, United States|Clinical Science Institute, Santa Monica, California, 90404, United States|California Dermatology Institute, Thousand Oaks, California, 91320, United States|Pediatric Skin Research, Coral Gables, Florida, 33146, United States|Ciocca Dermatology, Miami, Florida, 33173, United States|University of South Florida, Tampa, Florida, 33612, United States|NorthShore University HealthSystem, Skokie, Illinois, 60077, United States|Dawes Fretzin Clinical Research Group, LLC, Indianapolis, Indiana, 46250, United States|Southern Indiana Clinical Trials, New Albany, Indiana, 47150, United States|Great Lakes Research Group Inc- Sheffield, Bay City, Michigan, 48706, United States|Henry Ford Cancer Detroit (Brigitte Harris Cancer Pavilion), Detroit, Michigan, 48202, United States|Dermatology and Skin Cancer Center of Lees Summit, Lee's Summit, Missouri, 64064, United States|Boeson Research, Missoula, Montana, 59804, United States|Empire Dermatology, East Syracuse, New York, 13057, United States|State University of New York, Downstate Medical Center, Manhasset, New York, 11030, United States|OptiSkin Medical, New York, New York, 10029, United States|Hightower Clinical LLC, Oklahoma City, Oklahoma, 73120, United States|Dermatology Research Center of Oklahoma, PLLC, Tulsa, Oklahoma, 74132, United States|Oregon Health and Science University, Portland, Oregon, 97239, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States|Studies in Dermatology LLC, Cypress, Texas, 77429, United States|Austin Institute for Clinical Research, Pflugerville, Texas, 78660, United States|Stride Clinical Research LLC, Sugar Land, Texas, 77479, United States|Frontier Derm Partners, Mill Creek, Washington, 98012, United States Less << |
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NCT05767047 | Beh?et's Disease|Juvenile Psor... More >>iatic Arthritis Less << | PHASE3 | RECRUITING | 2036-03-28 | General Hospital of Thessaloni... More >>ki Ippokrateio, Thessaloniki, 54642, Greece|Meir Medical Center, Kfar Saba, 4428164, Israel|Hospital Universitari i Politecnic La Fe, Valencia, Comunidad Valenciana, 46026, Spain|Hospital Universitario Ramon y Cajal, Madrid, 28034, Spain|Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara, 06100, Turkey|Istanbul Universitesi Cerrahpasa Tip Fakultesi, Istanbul, 34098, Turkey|Umraniye Egitim ve Arastirma Hastanesi, Istanbul, 34764, Turkey Less << |
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NCT01045551 | Erythematotelangiectatic Rosac... More >>ea|Papulopustular Rosacea Less << | PHASE2 | COMPLETED | 2025-04-14 | Columbia University Medical Ce... More >>nter, New York, New York, 10032, United States Less << |
NCT03239106 | Itch | PHASE2 | COMPLETED | 2019-09-19 | Washington University Division... More >> of Dermatology, Saint Louis, Missouri, 63108, United States Less << |
NCT04031027 | Plaque Psoriasis | COMPLETED | 2021-01-27 | SOD Clinica Dermatologica A.O.... More >>U. Riuniti Umberto I Lancisi Salesi, Ancona, AN, 60126, Italy|UOC Dermatologia ASST Spedali Civili, Brescia, BS, 25123, Italy|Dermatologia Azienda Ospedaliera Papardo, Messina, ME, 98158, Italy|Dermatologica e Venereologia Univ. A.O.U. Consorziale Policlinico, Bari, 70124, Italy|UOS Clinica Dermatologica Ospedale San Giovanni di Dio, Cagliari, 09123, Italy|Dermatologia A.O.U. Policlinico-Vittorio Emanuele PO S.Marco, Catania, 95100, Italy|UOC Dermatologia Arcispedale Sant'Anna, Cona, 44124, Italy|Dermatologia Ospedale Piero Palagi, Firenze, 50025, Italy|UOC Dermatologia A.O.U. Policlinico G. Martino, Messina, 98125, Italy|Dermatologia A.O.U. Federico II, Napoli, 80131, Italy|UOC Clinica Dermatologica A.O.U. Università della Campania Vanvitelli, Napoli, 80138, Italy|Dermatologia A.O.U. Maggiore della Carità, Novara, 28100, Italy|UOC Dermatologia e MST A.O.U. Policlinico P. Giaccone, Palermo, 90127, Italy|Clinica Dermatologica Policlinico Tor Vergata, Roma, 00133, Italy|Dermatologia e Venereologia A.O.U. Policlinico Umberto I, Roma, 00161, Italy|UOC Dermatologia Universitaria Ospedale A. Fiorini, Terracina, 04019, Italy Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.17mL 0.43mL 0.22mL |
10.86mL 2.17mL 1.09mL |
21.72mL 4.34mL 2.17mL |