Structure of Zongertinib
CAS No.: 2728667-27-2
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Zongertinib is an effective HER2 and EGFR tyrosine kinase inhibitor with IC50 values of 13 nM and 579 nM, respectively. This compound exhibits significant anti-tumor activity, especially suitable for research on various solid tumors with potential applications in cancer therapy.
Synonyms: BI 1810631
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 2728667-27-2 |
Formula : | C29H29N9O2 |
M.W : | 535.60 |
SMILES Code : | C=CC(NC1CCN(C2=NC=C(N=CN=C3NC4=CC=C(OC5=CC=C6N(C)C=NC6=C5)C(C)=C4)C3=N2)CC1)=O |
Synonyms : |
BI 1810631
|
MDL No. : | N/A |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
Description |
Zongertinib (BI 1810631) is a potent and selective inhibitor of HER2 and EGFR tyrosine kinases, with IC50 values of 13 nM and 579 nM, respectively. It exhibits antitumor activity and holds promise for research in various solid tumors [1][2][3].
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Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT06581432 | Solid Tumours | PHASE2 | RECRUITING | 2027-09-30 | Alaska Oncology and Hematology... More >>, LLC, Anchorage, Alaska, 99508, United States|University of Arizona Comprehensive Cancer Center, Phoenix, Arizona, 85021, United States|Precision Next Gen Oncology, Beverly Hills, California, 90212, United States|Scripps Health, La Jolla, California, 92037, United States|Valkyrie Clinical Trials, Los Angeles, California, 90067, United States|University of California Los Angeles, Los Angeles, California, 90095, United States|Yale University, New Haven, Connecticut, 06520, United States|BRCR Global, Tamarac, Florida, 33321, United States|Illinois Cancer Specialists, Niles, Illinois, 60005, United States|Maryland Oncology Hematology, P.A, Rockville, Maryland, 20850, United States|Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, 48201, United States|Mount Sinai School of Medicine, New York, New York, 10029, United States|Memorial Sloan Kettering Cancer Center Basking Ridge, New York, New York, 10065, United States|Alliance Cancer Specialists, PC, Horsham, Pennsylvania, 19044, United States|Mary Crowley Cancer Research, Dallas, Texas, 75230, United States|The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States|Virginia Cancer Specialists, Fairfax, Virginia, 22031, United States|VCU Health Community Memorial Hospital, South Hill, Virginia, 23970, United States|Macquarie University, Macquarie University, New South Wales, 2113, Australia|Northern Cancer Institute, St Leonards, New South Wales, 2065, Australia|Princess Alexandra Hospital, Wooloongabba, Queensland, 4102, Australia|St John of God Subiaco Hospital, Subiaco, Western Australia, 6008, Australia|Cliniques Universitaires Saint-Luc, Bruxelles, 1200, Belgium|Universitair Ziekenhuis Antwerpen - UZA, Edegem, 2650, Belgium|Cross Cancer Institute, Edmonton, Alberta, T6G 1Z2, Canada|BC Cancer Agency - Vancouver, Vancouver, British Columbia, V5Z 4E6, Canada|Princess Margaret Cancer Centre, Toronto, Ontario, M5G 1Z9, Canada|Hopital Notre-Dame du CHUM, Montreal, Quebec, H2X 0C1, Canada|McGill University Health Centre (MUHC), Montreal, Quebec, H4A 3J1, Canada|The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China|Shanghai East Hospital, Shanghai, 200126, China|Henan Cancer Hospital, Zhengzhou, 450008, China|Institut Bergonié, Bordeaux, 33000, France|Centre Georges-Fran?ois Leclerc, Dijon, 21079, France|H?pital de la Milétrie - CHU de Poitiers, Poitiers, 86000, France|Institut Gustave Roussy, Villejuif, 94800, France|Universit?tsklinikum Gie?en, Gie?en, 35392, Germany|Asklepios Klinik Altona, Hamburg, 22763, Germany|Universit?tsklinikum Leipzig, Leipzig, 04103, Germany|Universit?tsklinikum Mannheim, Mannheim, 68167, Germany|Klinikum rechts der Isar der Technischen Universit?t München, München, 81675, Germany|Az. Ospedaliera Umberto I di Ancona, Ancona, 60020, Italy|Istituto Scientifico Romagnolo, Meldola (FC), 47014, Italy|Ospedale Niguarda Ca' Granda, Milano, 20162, Italy|AOU Università degli Studi della Campania Luigi Vanvitelli, Napoli, 80131, Italy|Aichi Cancer Center Hospital, Aichi, Nagoya, 464-8681, Japan|National Cancer Center Hospital East, Chiba, Kashiwa, 277-8577, Japan|Osaka International Cancer Institute, Osaka, Osaka, 541-8567, Japan|Shizuoka Cancer Center, Shizuoka, Sunto-gun, 411-8777, Japan|National Cancer Center Hospital, Tokyo, Chuo-ku, 104-0045, Japan|Japanese Foundation for Cancer Research, Tokyo, Koto-ku, 135-8550, Japan|Seoul National University Hospital, Seoul, 03080, Korea, Republic of|Severance Hospital, Seoul, 03722, Korea, Republic of|Asan Medical Center, Seoul, 05505, Korea, Republic of|Samsung Medical Center, Seoul, 135-710, Korea, Republic of|Nederlands Kanker Instituut, Amsterdam, 1066 CX, Netherlands|Radboudumc, Nijmegen, 6525 GA, Netherlands|Oslo Universitetssykehus HF, Radiumhospitalet, Oslo, N-0379, Norway|Pan American Center for Oncology Trials, LLC, Rio Piedras, 00935, Puerto Rico|Hospital Universitario A Coru?a, A Coru?a, 15006, Spain|Hospital del Mar, Barcelona, 08003, Spain|Hospital Universitari Vall d'Hebron, Barcelona, 08035, Spain|Hospital Clínico San Carlos, Madrid, 28040, Spain|Clínica Universidad de Navarra, Pamplona, 31008, Spain|Hospital Universitario Virgen del Rocío, Sevilla, 41013, Spain Less << |
NCT06075277 | Healthy | PHASE1 | COMPLETED | 2024-01-02 | CRS Clinical Research Services... More >> Berlin GmbH, Berlin, 13627, Germany Less << |
NCT06360081 | Healthy | PHASE1 | COMPLETED | 2024-06-30 | CRS Clinical Research Services... More >> Mannheim GmbH, Mannheim, 68167, Germany Less << |
Tags: Zongertinib | BI 1810631 | c-Met/HGFR | Protein Tyrosine Kinase/RTK | Tumor Growth, Proliferation and Apoptosis | 2728667-27-2
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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