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Chemical Structure| 3339-73-9 Chemical Structure| 3339-73-9
Chemical Structure| 3339-73-9

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Product Details of N-Phthaloyl-β-alanine

CAS No. :3339-73-9
Formula : C11H9NO4
M.W : 219.19
SMILES Code : OC(=O)CCN1C(=O)C2=C(C=CC=C2)C1=O
MDL No. :MFCD00023096
InChI Key :DXXHRZUOTPMGEH-UHFFFAOYSA-N
Pubchem ID :76859

Safety of N-Phthaloyl-β-alanine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of N-Phthaloyl-β-alanine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3339-73-9 ]

[ 3339-73-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3339-73-9 ]
  • [ 20605-41-8 ]
  • 3-(1,3-dioxoisoindolin-2-yl)-N'-(2-methoxyacetyl)propanehydrazide [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% EDCHCI (2.8 g, 15.0 mmol) was added to a solution of 3-(1,3-dioxoisoindolin-2-yl)propanoic acid (2.2 g, 10.0 mmol) in THF (30 mL followed by HOBt (1.84 g, 12.0 mmol) and the reaction mixture was stirred for 20 mm at room temperature. <strong>[20605-41-8]2-<strong>[20605-41-8]methoxyacetohydrazide</strong></strong> (1.05 g, 10.0 mmol) was added to the reaction mixture followed by DIPEA (6.4 g, 50.0 mmol) and thereaction mixture was stirred at room temperature for 16 h. Volatiles were removed under reduced pressure and the reaction mixture was diluted with water (30 mL). The aq. layer wasextracted with DCM (3 x 25 mL), combined organic layer was washed with aqueous NaHCO3 solution (50 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the product (2.0 g, 65 percent) as white solid. ?H NIvIR (400 MHz, DMSO-d6): 6 9.91 (s, 1H), 9.72 (s, IH), 7.88-7.82 (m, 4H), 3.88 (s, 2H), 3.78 (t, J= 7.6 Hz, 2H), 3.30 (s, 3H), 2.25 (t, J?7.6 Hz, 2H); LC-MS: [M+Hj = 306.3 mlz.
 

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