Structure of Indisulam
CAS No.: 165668-41-7
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Indisulam is a carbonic anhydrase inhbitor and a synthetic sulfonamide targeting the G1 phase of the cell cycle.
Synonyms: E 7070
4.5
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CAS No. : | 165668-41-7 |
Formula : | C14H12ClN3O4S2 |
M.W : | 385.85 |
SMILES Code : | O=S(C1=CC=C(S(=O)(N)=O)C=C1)(NC2=CC=CC3=C2NC=C3Cl)=O |
Synonyms : |
E 7070
|
MDL No. : | MFCD00945325 |
InChI Key : | SETFNECMODOHTO-UHFFFAOYSA-N |
Pubchem ID : | 216468 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319 |
Precautionary Statements: | P305+P351+P338 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03485950 | Other Infectious Diseases | Phase 2 | Recruiting | May 2019 | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact iraad@mdanderson.org Less << |
NCT00165867 | Colorectal Cancer | Phase 2 | Completed | - | France ... More >> Hôpitaux Civils de Colmar Colmar, France, F- 68024 CRLC Val d'Aurelle Montpellier, France, F-34298 Centre Antoine Lacassagne Nice, France, F-06189 United Kingdom Aberdeen Royal Infirmary Aberdeen, United Kingdom, AB25 2ZN Beatson Oncology Centre Glasgow, United Kingdom, G11 6NT Cookridge Hospital Leeds, United Kingdom, LS16 6QB Leicester Royal Infirmary Leicester, United Kingdom, LE1 5WW Less << |
NCT00059735 | Kidney Neoplasms ... More >> Carcinoma, Renal Cell Adenocarcinoma, Renal Cell Less << | Phase 2 | Completed | - | United States, California ... More >> Sacramento, California, United States, 95817 United States, New York Bronx, New York, United States, 10466 New York, New York, United States, 10021 New York, New York, United States, 10032 France Villejuif Cedex, France, 94805 Less << |
NCT00080197 | Breast Neoplasms ... More >> Metastases Less << | Phase 2 | Completed | - | - |
NCT01692197 | - | Completed | - | - | |
NCT00165854 | Colorectal Cancer (CRC) | Phase 2 | Completed | - | France ... More >> Centre Léon Bérard Lyon, France, F-69373 Institut Curie Paris, France, F-75005 Germany Universitätsklinikum der GHS-Essen Essen, Germany, D-45122 Netherlands Netherlands Cancer Institute Amsterdam, Netherlands, 1066 CX Less << |
NCT00014625 | Melanoma (Skin) | Phase 2 | Completed | - | Austria ... More >> Kaiser Franz Josef Hospital Vienna, Austria, A-1100 Belgium Institut Jules Bordet Brussels, Belgium, 1000 France Centre Jean Perrin Clermont-Ferrand, France, 63011 Centre Leon Berard Lyon, France, 69373 Centre Eugene Marquis Rennes, France, 35064 Germany Medizinische Hochschule Hannover Hannover, Germany, D-30625 Italy Istituto Nazionale per lo Studio e la Cura dei Tumori Naples, Italy, 80131 Norway Norwegian Radium Hospital Oslo, Norway, N-0310 Portugal Instituto Portugues de Oncologia de Francisco Gentil Lisbon, Portugal, 1093 Switzerland Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland, CH-1011 United Kingdom Royal Marsden NHS Trust London, England, United Kingdom, SW3 6JJ Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 2XU Less << |
NCT01692197 | Leukemia | Phase 2 | Completed | - | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00003981 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | Austria ... More >> Innsbruck Universitaetsklinik Innsbruck, Austria, A-6020 Kaiser Franz Josef Hospital Vienna, Austria, A-1100 Belgium Institut Jules Bordet Brussels, Belgium, B-1000 Ludwig Institute for Cancer Research Brussels, Belgium, B-1200 Universitair Ziekenhuis Antwerpen Edegem, Belgium, B-2650 U.Z. Gasthuisberg Leuven, Belgium, B-3000 Denmark Herlev Hospital - University Hospital of Copenhagen Copenhagen, Denmark, DK-2730 France Centre Jean Perrin Clermont-Ferrand, France, 63011 Centre Leon Berard Lyon, France, 69373 CRLCC Nantes - Atlantique Nantes-Saint Herblain, France, 44805 Institut Claudius Regaud Toulouse, France, 31052 Institut Gustave Roussy Villejuif, France, F-94805 Germany Universitaetsklinikum Essen Essen, Germany, D-45122 Netherlands Vrije Universiteit Medisch Centrum Amsterdam, Netherlands, 1001HV Antoni van Leeuwenhoekhuis Amsterdam, Netherlands, 1066 CX Academisch Ziekenhuis Groningen Groningen, Netherlands, 9700 RB University Medical Center Nijmegen Nijmegen, Netherlands, NL-6500 HB Erasmus University Medical Center Rotterdam, Netherlands, 3008 EA Norway Norwegian Radium Hospital Oslo, Norway, N-0310 Switzerland University Hospital Basel, Switzerland, CH-4031 Inselspital, Bern Bern, Switzerland, CH-3010 Kantonsspital - St. Gallen St. Gallen, Switzerland, CH-9007 United Kingdom Newcastle General Hospital Newcastle Upon Tyne, England, United Kingdom, NE4 6BE Royal Marsden Hospital Sutton, England, United Kingdom, SM2 5PT Ninewells Hospital and Medical School Dundee, Scotland, United Kingdom, DD1 9SY Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 2XU Less << |
NCT00003976 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | Austria ... More >> Innsbruck Universitaetsklinik Innsbruck, Austria, A-6020 Kaiser Franz Josef Hospital Vienna, Austria, A-1100 Belgium Institut Jules Bordet Brussels, Belgium, 1000 Ludwig Institute for Cancer Research-Brussels Branch Brussels, Belgium, B-1200 Universitair Ziekenhuis Antwerpen Edegem, Belgium, B-2650 U.Z. Gasthuisberg Leuven, Belgium, B-3000 Denmark Herlev Hospital - University Hospital of Copenhagen Herlev, Denmark, DK-2730 France Centre Jean Perrin Clermont-Ferrand, France, 63011 Centre Leon Berard Lyon, France, 69373 CRLCC Nantes - Atlantique Nantes-Saint Herblain, France, 44805 Institut Claudius Regaud Toulouse, France, 31052 Institut Gustave Roussy Villejuif, France, F-94805 Germany Universitaetsklinik und Strahlenklinik - Essen Essen, Germany, D-45122 Klinikum Nurnberg Nuremberg (Nurnberg), Germany, D-90419 Netherlands Antoni van Leeuwenhoekhuis Amsterdam, Netherlands, 1066 CX Academisch Ziekenhuis der Vrije Universiteit Amsterdam, Netherlands, 1117 MB Academisch Ziekenhuis Groningen Groningen, Netherlands, 9713 EZ University Medical Center Nijmegen Nijmegen, Netherlands, NL-6252 HB Rotterdam Cancer Institute Rotterdam, Netherlands, 3075 EA Norway Norwegian Radium Hospital Oslo, Norway, N-0310 Switzerland University Hospital Basel, Switzerland, CH-4031 Inselspital, Bern Bern, Switzerland, CH-3010 Kantonsspital - Saint Gallen Saint Gallen, Switzerland, CH-9007 United Kingdom Newcastle General Hospital Newcastle Upon Tyne, England, United Kingdom, NE4 6BE Ninewells Hospital and Medical School Dundee, Scotland, United Kingdom, DD1 9SY Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 9NQ C.R.C. Beatson Laboratories Glasgow, Scotland, United Kingdom, G61 1BD Less << |
NCT00165880 | Metastatic Breast Cancer | Phase 2 | Terminated(This study was stop... More >>ped prematurely due to lack of efficacy.) Less << | - | Germany ... More >> Charite Universitatsmedizin Berlin Berlin, Germany, D-12200 Stadt Kliniken Frankfurt-Hochst Frankfurt, Germany, D-65929 IORC Gmbh Hamburg, Germany, D-22081 Medizinische Klinik und Poliklinik Mainz, Germany, D-55101 Zentrum fur Innere Medizin Hamatologie / Onkologie Stuttgart, Germany, D-70376 Italy Ospedali Ruiniti Bergamo, Italy, I-24128 Ospedale S. Maria Annunzialata Firenze, Italy, I-50011 Ospedale Morgagni-Pierantoni Forli, Italy, I-47100 IST Istituto nazionale per la Ricerca Genova, Italy, I-16132 Palilinico Universitano Palermo, Italy, I-90127 Azienda Ospedaliera Pisana Pisa, Italy, I-56126 A.O. Arciospedate S. Maria Nuova Reggio Emilia, Italy, I-42100 Ospedale San Filippo Neri Roma, Italy, I-00135 Russian Federation Arkhangelsk Regional Clinical Oncology Center Arkhangelsk, Russian Federation, 163045 Chelyabinsk Regional Oncology Center Chelyabinsk, Russian Federation, 454087 Krasnodar City Oncology Center Krasnodar, Russian Federation, 350040 Leningrad Regional Oncology Center Kuzmolovo, Russian Federation, 188663 Hertzen Research Institute of Oncology Moscow, Russian Federation, 125284 Semashko Central Clinical Hospital Moscow, Russian Federation, 129128 Rostov Oncology Research Institute Rostov-on-Don, Russian Federation, 344037 Petrov Research Institute of Oncology St. Petersburg, Russian Federation, 197758 Spain Hospital Universiatio de Guadalajara Guadalajara, Spain, I-19002 Centro Oncologico Regional de Galicia La Coruna, Spain, E-15009 Hospital Unicersaitario de La Princesa Madrid, Spain, E-28006 Centro Oncologico Anderson Internacional Madrid, Spain, E-28033 Hospital Clinico U. Virgen de la Victoria Malaga, Spain, E-29010 Hospital Clinico Universitario Lozano Blesa Zaragoza, Spain, E-50009 Hospital Clinico Universitario Lozano Blesa Zaragoza, Spain, I-19002 United Kingdom Cookridge Hospital Leeds, United Kingdom, LS16 6QB St Bartholomew's Hospital London, United Kingdom, EC1A 7BE Christie Hospital NHS Trust Manchester, United Kingdom, M20 4GJ Mount Vernon Cancer Centre Northwood, United Kingdom, HA1 2RN South West Wales Cancer Institute Swansea, United Kingdom, SA2 8QA Less << |
NCT00060567 | Cancer | Phase 1 | Completed | - | United States, Massachusetts ... More >> Boston, Massachusetts, United States Less << |
NCT00165594 | Gastric Cancer | Phase 1 Phase 2 | Terminated(Study was completed... More >>.) Less << | - | Japan ... More >> Kashiwa, Chiba-prefecture, Japan, 277-0882 Sagamihara-shi, Kanagawa, Japan Takatsuki-shi, Osaka, Japan Sunto-gun, Shizuoka-prefecture, Japan, 411-0934 Chuo-ku, Tokyo, Japan, 104-0045 Less << |
Tags: Indisulam | E 7070 | Indoles | Chlorides | Sulfamides | Amines | Aryls | RBM39/PROTAC | Molecular Glues | Others | HIV | Carbonic Anhydrase | Structure | Steroids | Anti-Infection | Biological Buffers | Fluorescence Labeling Reagents | Metabolic Enzyme | Organic Building Blocks | Fluorescent Dyes | Exosome | Small Molecule Positive Drugs | Molecular Glue | Other Inhibitors/Agonists | Heterocyclic Building Blocks | 165668-41-7
Precautionary Statements-General | |
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P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
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P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
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P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
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P309 | IF exposed or if you feel unwell: |
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P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
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P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
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P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
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P413 | |
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P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
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P411 + P235 | Keep cool. |
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P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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