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Chemical Structure| 56995-20-1 Chemical Structure| 56995-20-1

Structure of Flupirtine
CAS No.: 56995-20-1

Chemical Structure| 56995-20-1

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Flupirtine is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.

Synonyms: D 9998

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Product Details of Flupirtine

CAS No. :56995-20-1
Formula : C15H17FN4O2
M.W : 304.32
SMILES Code : O=C(NC1=CC=C(N=C1N)NCC2=CC=C(C=C2)F)OCC
Synonyms :
D 9998
MDL No. :MFCD00864265
InChI Key :JUUFBMODXQKSTD-UHFFFAOYSA-N
Pubchem ID :53276

Safety of Flupirtine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P280

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00623415 Relapsing Remitting Multiple S... More >>clerosis Less << Phase 2 Terminated - Germany ... More >> NeuroCure Clinical Research Center, Charité Berlin Berlin, Germany, 10117 Carl-Thiem-Clinic Cottbus Cottbus, Germany, 03048 University of Göttingen, Department of Neurology Göttingen, Germany, 37075 University of Ulm, Department of Neurology Ulm, Germany Less <<
NCT01676246 Pain Pharmaco... More >>kinetics Flupirtine Less << Phase 1 Completed - Germany ... More >> Department of Clinical Pharmacology, Ernst-Moritz-Arndt-University Greifswald Greifswald, Mecklenburg-Vorpommern, Germany, 17487 Less <<
NCT01450865 Axonal Change, Neuronal ... More >> Pain Less << Phase 1 Completed - Germany ... More >> Multidisciplinary Pain Unit Department of Anaesthesiology University of Munich Pettenkoferstr. 8a Munich, Bavaria, Germany, 80336 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.29mL

0.66mL

0.33mL

16.43mL

3.29mL

1.64mL

32.86mL

6.57mL

3.29mL

References

[1]Swedberg MD, Shannon HE, et al. Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat. J Pharmacol Exp Ther. 1988 Sep;246(3):1067-74.

[2]Wu SN, Hsu MC, et al. Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells. Evid Based Complement Alternat Med. 2012;2012:148403.

[3]Kornhuber J, Bleich S, Wiltfang J, Maler M, Parsons CG. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication. J Neural Transm (Vienna). 1999;106(9-10):857-867

[4]Klinger F, Geier P, Dorostkar MM, et al. Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. Br J Pharmacol. 2012;166(5):1631-1642

[5]Swedberg MD, Shannon HE, Nickel B, Goldberg SR. Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat. J Pharmacol Exp Ther. 1988;246(3):1067-1074

[6]Wu SN, Hsu MC, Liao YK, Wu FT, Jong YJ, Lo YC. Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells. Evid Based Complement Alternat Med. 2012;2012:148403

[7]Kolosov A, Goodchild CS, Williams ED, Cooke I. Flupirtine enhances the anti-hyperalgesic effects of morphine in a rat model of prostate bone metastasis. Pain Med. 2012;13(11):1444-1456

 

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