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Chemical Structure| 99285-38-8 Chemical Structure| 99285-38-8

Structure of 99285-38-8

Chemical Structure| 99285-38-8

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Product Details of [ 99285-38-8 ]

CAS No. :99285-38-8
Formula : C10H21NO2
M.W : 187.28
SMILES Code : CC(C)(C)C(N)C(OC(C)(C)C)=O

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Application In Synthesis of [ 99285-38-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 99285-38-8 ]

[ 99285-38-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33105-81-6 ]
  • con H2SO4 [ No CAS ]
  • [ 96042-30-7 ]
  • [ 115-11-7 ]
  • [ 99285-38-8 ]
YieldReaction ConditionsOperation in experiment
72% With NaOH; In 1,4-dioxane; Method A2R-Amino-3,3-dimethyl-butyric acid (5.02 g, 37.2 mmol) was added to a solution of DCM (25 mL) and dioxane (25 mL) in a glass pressure tube and cooled to -30° C. in a dry ice acetone bath. con H2SO4 (2.75 mL, 41.98 mmol) was added to the solution.Isobutene (25 mL) was condensed in a dry ice bath and added to the solution.The reaction mixture was warmed to rt over 1 h, then heated to 40° C. for 2 days.Reaction was cooled to -30° C. and the vessel was opened.Adjust the solution to pH=10 with 2N NaOH.The mixture was partition between Et2O and H2O.The aqueous layer was washed with Et2O three times, and the combined organic layers were extracted with brine and dried over Na2SO4.The drying agent was removed by vacuum filtration and 2R-amino-3,3-dimethyl-butyric acid tert-butyl ester (5.12 g, 72percent) was isolated by the evaporation of solvent under reduced pressure to afford a colorless oil.LC/MS=188 (M++1)
 

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