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Chemical Structure| 95977-29-0 Chemical Structure| 95977-29-0

Structure of 95977-29-0

Chemical Structure| 95977-29-0

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Product Details of [ 95977-29-0 ]

CAS No. :95977-29-0
Formula : C15H11ClF3NO4
M.W : 361.70
SMILES Code : C[C@@H](OC1=CC=C(OC2=NC=C(C(F)(F)F)C=C2Cl)C=C1)C(O)=O
MDL No. :MFCD20036282

Safety of [ 95977-29-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H412
Precautionary Statements:P273

Application In Synthesis of [ 95977-29-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 95977-29-0 ]

[ 95977-29-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1310-58-3 ]
  • [ 69045-84-7 ]
  • [ 94050-90-5 ]
  • [ 95977-29-0 ]
YieldReaction ConditionsOperation in experiment
In water; Preparation of R-(+)-2-[4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-phenoxy]propionic acid In 200 ml of diemthylsulfoxide, 13 g of <strong>[94050-90-5]R-(+)-2-(4-hydroxyphenoxy)propionic acid</strong> and 9.45 g of potassium hydroxide powder were dissolved under nitrogen atmosphere. To this mixture, was added dropwise 15.5 g of 2,3-dichloro-5-trifluoromethyl pyridine at room temperature, and the resulting mixture was stirred at 70 C. for 15 hours. The thus obtained reaction mixture was poured into 1000 ml of water, followed by acidification with concentrated hydrochloric acid and by extraction with ether. The ether layer was dried over anhydrous magnesium sulfate and evaporated the solvent to obtain 20.9 g of R-(+)-2-[4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)-phenoxy]propionic acid.
  • 2
  • [ 69045-84-7 ]
  • [ 94050-90-5 ]
  • [ 95977-29-0 ]
YieldReaction ConditionsOperation in experiment
84.4% (R) -2- (4-hydroxyphenoxy) propionic acid (3.00 g), DMF (35 ml), slowly adding K2CO3 (4.55 g)70~80C , stirring 1h, by adding 2,3-dichloro-5-trifluoromethylpyridine (3.56g), keep 70 ~ 80 C stirring 8h, stopThe reaction was allowed to cool to room temperature, the mixture was poured into ice water (100 mL), adjusted to pH 4 to 5 using dilute hydrochloric acid, (R)-2-[4-(5-trifluoromethyl-3-chloropyridin-2-yloxy)phenoxy]propanone, and the organic phase was washed with water, Acid brown liquid 5.03g, yield 84.4%.
84.4% (R) -2- (4-hydroxyphenoxy) propionic acid (3 g),DMF (35 ml),K2CO3 (4.55 g) was added slowly,Heating up to 70 ~ 80 ,Stir for 1h,Was added dropwise 2,3-dichloro-5-trifluoromethylpyridine (3.56 g)Keep at 70 ~ 80 stirring 8h,Stop the reaction,Naturally cooled to room temperature,The mixture was poured into ice water (200 mL)The use of dilute hydrochloric acid to adjust the pH 4 to 5,Extracted with ethyl acetate,Organic phase washed,dry,(R) -2- [4- (5-trifluoromethyl-3-chloropyridin-2-yloxy) phenoxy] propionic acidBrown liquid5.03g,Yield 84.4%.
84.4% (R) -2- (4-hydroxyphenoxy) propionic acid (3 g),DMF (35 ml),K2CO3 (4.55 g) was added slowly,Heating up to 70 ~ 80 ,Stir for 1h,Was added dropwise 2,3-dichloro-5-trifluoromethylpyridine (3.56 g)Keep at 70 ~ 80 stirring 8h,Stop the reaction,Naturally cooled to room temperature,The mixture was poured into ice water (200 mL)The use of dilute hydrochloric acid to adjust the pH 4 to 5,Extracted with ethyl acetate,Organic phase washed,dry,5.03 g of (R) -2- [4- (5-trifluoromethyl-3-chloropyridin-2-oxy) phenoxy] propionic acidYield 84.4%.
84.4% (R) -2- (4-hydroxyphenoxy) propionic acid(3g),DMF (35 ml), slowly adding K2CO3 (4.55 g),The temperature was raised to 70 to 80 C, stirred for 1 h, and 2,3-dichloro-5-trifluoromethylpyridine (3.56 g)Keep at 70 ~ 80 stirring 8h,The reaction was stopped and the mixture was allowed to cool to room temperature and the mixture was poured into ice water (200 mL)The use of dilute hydrochloric acid to adjust the pH 4 to 5,Extracted with ethyl acetate, washed with organic phase, dried and desolved(R) -2- [4- (5-trifluoromethyl-3-chloropyridin-2-oxy) phenoxy] propionic acid brownThe color liquid was 5.03 g, 84.4% yield
84.4% (R) -2- (4-hydroxyphenoxy) propionic acid (3 g),DMF (35 ml), slowly adding K2CO3 (4.55 g),Heating up to 70 ~ 80 ,Stir for 1h,Was added dropwise 2,3-dichloro-5-trifluoromethylpyridine (3.56 g)Keep at 70 ~ 80 for 8h,Stop the reaction,Naturally cooled to room temperature,The mixture was poured into ice water (200 mL)The pH was adjusted to 4 to 5 using dilute hydrochloric acid, extracted with ethyl acetate,Organic phase washed,dry,(R) -2- [4- (5-trifluoromethyl-3-chloropyridin-2-yloxy) phenoxy]Propionic acid brown liquid 5.03 g,Yield 84.4%.
84.4% <strong>[94050-90-5](R)-2-(4-hydroxyphenoxy)propionic acid</strong> (3g),DMF (35ml),Slowly add K2CO3 (4.55g),Warm up to 70-80 C, stir for 1 h,Add 2,3-dichloro-5-trifluoromethylpyridine (3.56 g) dropwise, keep stirring at 70-80 C for 8 h, stop the reactionIt should be naturally cooled to room temperature, poured into ice water (200 mL), adjusted to pH 4-5 with dilute hydrochloric acid, with ethyl acetateExtraction, organic phase washing, drying, de-solubilization to obtain (R)-2-[4-(5-trifluoromethyl-3-chloropyridin-2-yloxy)phenoxy]propionic acidBrown liquid 5.03g, yield 84.4%
84.4% (R)-2 - (4 - hydroxy-phenoxy) propionic acid (3.00 g), DMF (35 ml), slowly adding K2CO3(4.55 G), heated to 70 - 80 C, stirring 1 h, added dropwise 2, 3 - dichloro -5 - trifluoro methyl pyridine (3.56 g), keep the 70 - 80 C stirring 8 h, stopping the reaction, natural cooling to room temperature, the mixture is poured into ice water (100 ml) in, using diluted hydrochloric acid to adjust the pH 4 - 5, extracted with ethyl acetate, the organic phase with water washing, drying, shall desolution (R)-2 - [4 - (5 - trifluoromethyl -3 - chloro pyridine -2 - yloxy) phenoxy] propionic acid brown liquid 5.03 g, yield 84.4%.

 

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