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Chemical Structure| 959617-74-4 Chemical Structure| 959617-74-4

Structure of 959617-74-4

Chemical Structure| 959617-74-4

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Product Details of [ 959617-74-4 ]

CAS No. :959617-74-4
Formula : C8H5FN2
M.W : 148.14
SMILES Code : FC1=CC2=NC=CC=C2N=C1
MDL No. :MFCD20040402

Safety of [ 959617-74-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 959617-74-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 959617-74-4 ]

[ 959617-74-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 14756-77-5 ]
  • [ 959617-74-4 ]
YieldReaction ConditionsOperation in experiment
To 2 mL of hydrogen fluoride/pyridine, 145 mg of 1,5-naphthyridin-3-amine was added at 0C, 76 mg of sodium nitrite was added to the reaction mixture, and stirred at 0C for 1 hour. The reaction mixture was stirred at 60C for 1 hour, and neutralized with a saturated aqueous sodium hydrogen carbonate solution at 0C, chloroform was then added thereto, and the organic layer was separated. The organic layer was washed with a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography using silica gel; Silica Gel 60N made by KANTO CHEMICAL CO., INC., and an eluent of chloroform:methanol = 20:1 to obtain 77 mg of 3-fluoro-1,5-naphthyridine as a light yellow solid. 1H-NMR (CDCl3) δ: 7.62-7.67 (1H, m), 8.03-8.08 (1H, m), 8.42-8.47 (1H, m), 8.90-8.94 (1H, m), 8.98-9.03 (1H, m)
 

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