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Chemical Structure| 957202-21-0 Chemical Structure| 957202-21-0

Structure of 957202-21-0

Chemical Structure| 957202-21-0

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Product Details of [ 957202-21-0 ]

CAS No. :957202-21-0
Formula : C12H17NO
M.W : 191.27
SMILES Code : O[C@H](C1=CC=CC=C1)C2CCNCC2

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Application In Synthesis of [ 957202-21-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 957202-21-0 ]

[ 957202-21-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 193217-39-9 ]
  • [ 957202-21-0 ]
YieldReaction ConditionsOperation in experiment
Example 4 Synthesis of (S)-phenyl(piperidin-4-yl)methanol (1S)-(+)10-camphorsulfonic acid salt; To a solution of (-)-DIPCl (315 mL, 0.57 mol, 63.6 % in heptane) in THF anhydrous (1 1), 4-(benzoyl)piperidine-1-carboxylic acid tert-butyl ester (75.0 g, 0.26 mol) was added at room temperature. After 21 hours acetaldehyde (55 mL) was added, stirring continued for 3 h at room temperature and then 25 % aq NaOH added and the mixture stirred for 45 min. The organic phase was separated, washed with brine, the solvent removed under reduced pressure and the residue treated with dichloromethane. The aqueous phase was treated with 30 % aqueous NaOH, extracted with dichloromethane, dried, filtered and concentrated to give a brown oil (56 g) wich was dissolved in THF (300 mL), treated with (1S)-(+)-camphorsulphonic acid (51.9 g) and heated until 85 C. After 20 h at room temperature a white solid was filtered (mp 148.1-150.9 C, yield: 55.3 %, 99.9 % ee)
 

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