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Chemical Structure| 956389-20-1 Chemical Structure| 956389-20-1

Structure of 956389-20-1

Chemical Structure| 956389-20-1

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Product Details of [ 956389-20-1 ]

CAS No. :956389-20-1
Formula : C18H15N5O3S
M.W : 381.41
SMILES Code : O=C(C1=CC2=NC(C3=CC=CC4=C3C=NN4)=NC(N5CCOCC5)=C2S1)O

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Application In Synthesis of [ 956389-20-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 956389-20-1 ]

[ 956389-20-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 956388-76-4 ]
  • [ 1023595-17-6 ]
  • [ 956389-20-1 ]
YieldReaction ConditionsOperation in experiment
80% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In N,N-dimethyl acetamide; water; at 120℃; for 0.5h;Microwave irradiation; Step 16b: 2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid (Intermediate 16b) A mixture of Intermediate 16a (90 mg, 0.3 mmol), <strong>[1023595-17-6]1H-indazol-4-ylboronic acid</strong> (64 mg, 0.39 mmol), 17 mg of Pd(PPh3)4 in 1 mL of DMA and 0.5 mL of 1M aqueous Na2CO3, was heated at 120 C. for 30 min under microwave condition. The reaction mixture was diluted with 2 mL of MeOH and 1 mL of water, and filtrated. 1N of aqueous HCl and 4 mL of acetonitrile were added into the filtrate, the browny solid was then filtered and dried, giving desired acid 91 mg (80%). LC-MS: m/z 382.1 (ES+).
 

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