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Chemical Structure| 955036-78-9 Chemical Structure| 955036-78-9

Structure of 955036-78-9

Chemical Structure| 955036-78-9

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Product Details of [ 955036-78-9 ]

CAS No. :955036-78-9
Formula : C10H8F4O2
M.W : 236.16
SMILES Code : O=C(OC)CC1=CC(C(F)(F)F)=CC(F)=C1

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Application In Synthesis of [ 955036-78-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 955036-78-9 ]

[ 955036-78-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 67-56-1 ]
  • [ 195447-79-1 ]
  • [ 955036-78-9 ]
YieldReaction ConditionsOperation in experiment
100% With hydrogenchloride; In water; for 2.5h;Heating / reflux; Example 12 Synthesis of Ester Precursors to Compounds of Formula II Methyl 3-fluoro-5-trifluorophenylacetate A mixture of <strong>[195447-79-1]3-Fluoro-5-trifluoromethyl-phenylacetic acid</strong> (4.72 g, 21.2 mmol) and concentrated HCl (1.2 mL) in MeOH (50 mL) was refluxed for 2.5 h, then concentrated in vacuo. The residue was partitioned between 100 mL of EtOAc and washed sequentially with 0.5N aqueous NaOH (30 mL), 2% NaHCO3 solution (30 mL), and brine (30 mL). The EtOAc layer was dried (Na2SO4), filtered, and concentrated to provide 5.01 g (quantitative) of methyl 3-fluoro-5-trifluoromethyl-phenylaceiate as a colorless oil: 1H NMR (CDCl3, 300 MHz) delta 3.69 (s, 2H), 3.73 (s, 3H), 7.21-7.73 (m, 3H).
 

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