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Chemical Structure| 947763-36-2 Chemical Structure| 947763-36-2

Structure of 947763-36-2

Chemical Structure| 947763-36-2

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Product Details of [ 947763-36-2 ]

CAS No. :947763-36-2
Formula : C19H18N2O5
M.W : 354.36
SMILES Code : O=C(OC)CC1=NC=C(OC2=CC=NC3=CC(OC)=CC=C23)C=C1OC

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Application In Synthesis of [ 947763-36-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 947763-36-2 ]

[ 947763-36-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 68500-37-8 ]
  • [ 947688-90-6 ]
  • [ 947763-36-2 ]
YieldReaction ConditionsOperation in experiment
With dmap; In chlorobenzene; for 5h;Heating / reflux; Under an atmosphere of argon, a mixture of methyl 2-(5-hydroxy-3-methoxypyridin-2-yl)acetate (0.749 g), <strong>[68500-37-8]4-chloro-7-methoxyquinoline</strong> (J. Med. Chem., 1998, 41, 4918-4926; 0.772 g), 4-dimethylaminopyridine (1.49 g) and chlorobenzene (10 ml) was stirred and heated to reflux for 5 hours. The resultant mixture was cooled to ambient temperature and partitioned between water and ethyl acetate. The organic phase was washed with dilute aqueous hydrochloric acid, dried over magnesium sulphate and evaporated. The residue was stirred under diethyl ether. The resultant solid was isolated. There was thus obtained methyl 2-[3-methoxy-5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl]acetate (0.99 g); 1H NMR: (DMSOd6) 3.64 (s, 3H), 3.82 (s, 3H), 3.83 (s, 2H), 3.95 (s, 3H), 6.57 (d, 1H), 7.31 (m, 1H), 7.43 (d, 1H), 7.54 (d, 1H), 8.09 (s, 1H), 8.21 (d, 1H), 8.65 (d, 1H); Mass Spectrum: M+H+ 355.
 

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