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Chemical Structure| 944133-93-1 Chemical Structure| 944133-93-1

Structure of 944133-93-1

Chemical Structure| 944133-93-1

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Product Details of [ 944133-93-1 ]

CAS No. :944133-93-1
Formula : C9H11NO3
M.W : 181.19
SMILES Code : O=C(OC)C1=CN=C(C(O)C)C=C1

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Application In Synthesis of [ 944133-93-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 944133-93-1 ]

[ 944133-93-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 10165-86-3 ]
  • [ 944133-93-1 ]
YieldReaction ConditionsOperation in experiment
70% Step A:Preparation of methyl 6-(1-hydroxyethyl)nicotinateTo a -78° C. solution of methyl 6-formylnicotinate (0.300 g, 1.82 mmol) in tetrahydrofuran (6 mL) was added methylmagnesium bromide (0.787 mL, 3M in THF, 2.36 mmol) over 20 minutes.The solution was warmed to 0° C. and stirred for 2 hours.The mixture was quenched with saturated ammonium chloride, extracted with ethyl acetate, dried over sodium sulfate, filtered and concentrated.Purification by preparative TLC gave methyl 6-(1-hydroxyethyl)nicotinate (230 mg, 70percent) as a red oil. 1H NMR (400 MHz, CD3OD, 5): 8.93 (m, 1H), 8.26-8.29 (m, 1H), 7.59 (d, 1H), 4.73-4.83 (m, 1H), 3.84 (s, 3H), 1.37 (d, 3H).
 

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