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Chemical Structure| 943847-30-1 Chemical Structure| 943847-30-1

Structure of 943847-30-1

Chemical Structure| 943847-30-1

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Product Details of [ 943847-30-1 ]

CAS No. :943847-30-1
Formula : C10H6BrNO
M.W : 236.06
SMILES Code : O=CC1=CC=C(Br)C2=C1C=NC=C2

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Application In Synthesis of [ 943847-30-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 943847-30-1 ]

[ 943847-30-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 81045-39-8 ]
  • [ 68-12-2 ]
  • [ 943847-29-8 ]
  • [ 943847-30-1 ]
YieldReaction ConditionsOperation in experiment
To a stirred mixture of <strong>[81045-39-8]5,8-dibromoisoquinoline</strong> (4.0 g. 13.9 mmol) in tetrahydrofuran (120 mL) at -78 0C under nitrogen atmosphere was added dropwise a solution of rc-butyllithium (2.3 M in hexane, 7.3 mL, 16.8 mmol). The reaction mixture turned dark. After stirring for 15 minutes, the reaction mixture was quenched by adding lambdazetaiV-dimethylformamide (4.0 mL). After stirring at -78 0C for an additional 1 h, the reaction mixture was quenched with water, extracted with mixture of ethyl acetate/hexane (2:8), washed with water and brine, dried (Na2SO4), and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using hexanes/ethyl acetate as eluent to afford the 8-bromo-5-isoquinolinecarboxaldehyde (0.10 g), followed by 5-bromo-8-isoquinoIinecarboxaldehyde (1.0 g) as white solids.1H NMR (CDCl3) of S-bromo-5-isoquinolinecarboxaldehyde: 10.36 (s, IH), 9.72 (s, IH), 9.00 (d, IH), 8.79 (d, IH), 8.04 (d, IH), 8.01 (dd, IH); and1H NMR (CDCl3) of S-bromo-S-isoquinolinecarboxaldehyde: 10.57 (s, IH), 10.41 (s, IH), * 8.81 (d, IH), 8.18 (d, IH), 8.11 (d, IH), 7.94 (d, IH).
 

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